Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Injection into mice of the anthracycline cytotoxic derivative Doxorubicin (DXR) covalently bound to bovine serum albumin (BSA) was associated with antigen-specific depression of the primary (but not of the secondary) antibody reaction to the carrier, whereas DXR and BSA injected in the form of a mixture caused no such effect. Tetanus toxoid completely prevented the carrier-specific inhibiting effect when administered at the same time as, but not three days before or after, injection of the DXR-BSA conjugate. Possible mechanisms of the antigen-specific immunodepression and its prevention by unrelated antigen are discussed.
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PMID:Antigen-specific immunodepression induced by doxorubicin-BSA conjugate in mice. 207 Dec 92

The growth of Tetrahymena was influenced by both diphtheria and tetanus toxoids; depression occurred at a high and stimulation at a low concentration. Pretreatment with the stimulating concentration of diphtheria toxoid caused a lasting modification of growth rate and development of imprinting that resulted in an enhanced response of the cell at reexposure to the toxoid. Tetanus toxoid failed to induce either switch over of cell function or imprinting.
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PMID:Effect of diphtheria and tetanus toxoids on the growth of, and imprinting developed in, Tetrahymena. 310 91