Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two groups of guinea pigs were maintained on high-protein and low-protein diets and immunized with intradermal BCG. Protein deficiency was accompanied by marked inhibition of local and systemic immune responses: a) The BCG nodule was poorly formed. There was marked delay and deficiency in the mobilization of macrophages. b) The draining lymph node was atrophic and showed little or no proliferation of lymphoid cells in the paracortical area. Macrophage accumulation occurred late but became diffuse and marked, in contrast to its consistent scarcity in the BCG nodule. c) In either location epithelioid cell transformation was retarded. Well-formed mature epithelioid cell granulomas were not seen. d) Bacilli persisted for a long time in the skin and lymph node lesions, e) Tuberculin sensitivity was greatly impaired in one-fifth of animals and absent in others. These findings were suggestive of macrophage dysfunction and depression of cell-mediated immunity to BCG in the protein-deficient guinea pig.
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PMID:Immune responses of the protein-deficient guinea pig to BCG vaccination. 472 96

In vitro lymphocyte stimulation was performed on peripheral blood lymphocytes from 48 leprosy patients, 15 healthy contacts of leprosy patients, and 16 normal controls who lived in a leprosy-free area and who had not been exposed to leprosy. Tuberculin PPD and an antigen fraction. MLW 1, prepared from M. leprae, were used as stimulants. The MLW 1 preparation contained one antibody-precipitable component when tested in crossed immunoelectrophoresis against a polyvalent anti-M. leprae immunoglobulin preparation, namely the ML 7 antigen. MLW 1 induced strong lymphocyte responses in patients with tuberculoid leprosy and healthy contacts of leprosy patients, but only a weak or no responses in lepromatous leprosy patients and non-exposed controls. A marked depression of the response to tuberculin PPD was observed in lepromatous leprosy patients. The specificity of the MLW 1 antigen is discussed, and a new estimator of specific lymphocyte stimulation, the delta cpm', is introduced.
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PMID:In vitro stimulation of lymphocytes in leprosy patients, healthy contacts of leprosy patients, and subjects not exposed to leprosy. Comparison of an antigen fraction prepared from Mycobacterium leprae and tuberculin-purified protein derivative. 618 10

Studies of patients with atopic dermatitis show both clinical and laboratory evidence of a depression of cellular immunity. In order to study one aspect of this disease in vivo we studied 40 patients with atopic dermatitis of both sexes, aged 2-30 years and 40 supposedly healthy subjects with similar characteristics in regard to age and sex who served as the control group. Both groups were subjected to tests of delayed hypersensitivity with Candidin, Trycophytin and Tuberculin. Candidin response was negative in 72.5% and 85% at 48 and 72 hours respectively. Trycophytin response was negative in 77.5% and 87.5% of the readings at the same time intervals, and Tuberculin response was negative in 85.5% of the patients with atopic dermatitis studied. The results are shown to be statistically significant. It is concluded that, cellular immunity should be evaluated in patients with atopic dermatitis.
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PMID:Atopic dermatitis and delayed hypersensitivity. 685 5

1. A high degree of cellular sensitivity to tuberculin toxicity was demonstrated when explants from tuberculous animals were grown in media containing that substance. 2. Similar degrees of sensitivity were noted in cells derived from animals infected with either virulent or relatively lowly virulent strains of tubercle bacilli. 3. The specificity of the tuberculin cytotoxicity was proven by testing with other bacterial cytotoxic materials. 4. Tuberculin sensitive cells grown in vitro in normal media showed, when tested with tuberculin, persistence of this cellular sensitivity through several transplantations during which time many new generations of cells developed. 5. There was a depression of the initial growth energy of explants from animals during the toxic phase of the disease. During the healing stage the initial growth energy returned to normal although marked sensitivity to tuberculin persisted. 6. The degree of cellular sensitivity to tuberculin in vitro did no parallel the acuity of the infectious process but represented a more or less permanent acquired characteristic impressed on the cell as a result of the infection.
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PMID:TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : I. TUBERCULIN SENSITIVE TISSUES. 1987 May 39