Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of the novel putative anxiolytic, tracazolate, were investigated in the social interaction of anxiety and the holeboard. Tracazolate (5 mg/kg) had an anxiolytic action that was no longer observed at higher doses (10-25 mg/kg); in the holeboard tracazolate produced a dose-related (5-25 mg/kg) depression of exploratory head-dipping, locomotor activity and rearing. The effects of tracazolate in the social interaction test, but not in the holeboard, could be reversed by the benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg).
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PMID:The anxiolytic but not the sedative properties of tracazolate are reversed by the benzodiazepine receptor antagonist, Ro 15-1788. 287 13