Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

(I.) Toxicity of ionic coronary arteriography contrast media has been shown to depend on their cationic and anionic composition and their osmolality. Using a right coronary injection technique in the dog, the authors have shown a relationship between toxicity as manifested by occurrence of ventricular fibrillation and the presence of calcium binders in the contrast media. Sodium citrate and EDTA have been identified as the specific agents in certain contrast media that significantly increase the incidence of fibrillation in laboratory experiments. (II.) A deleterious synergism between water-soluble angiographic and urographic media and digitalis compounds has now been demonstrated, based on mortality studies (LD50) using bolus intravenous injections in white mice. The testing of a number of other classes of drugs for a similar effect has shown thus far that only the digitalis class exhibits this synergism. Surprisingly, the nonionic contrast medium, metrizamide, has been shown to have a greater synergistic effect with digitalis drugs than diatrizoate ionic media. (III.) In dog experiments under Nembutal anesthesia in which aortic flow, pulmonary artery and vein pressures, systemic arterial pressure, and EKG were monitored, left atrial pressure increases as soon as or before pulmonary artery pressure rises, even at low doses of ionic contrast media administered intravenously. This may indicate 1) flow to the left heart increases dramatically, or 2) there is a very early myocardial depression. The significance of the above findings and application to clinical practice will be discussed.
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PMID:Cardiovascular radiology. Possible factors in intravascular contrast media toxicity. 720 28

Indications to hemadsorption in patients with grave poisonings with clofelin have been defined. Two variants of hemadsorption for such patients have been developed and tried: hemadsorption in parallel with transesophageal electrocardiostimulation and that with blood stabilization with sodium citrate in the extracorporeal contour. Hemadsorption brought about a good clinical effect, normalized hemo- and cardiodynamics, removed depression of the sinus node function and the conduction tract of the heart. Sodium citrate stabilization of the blood did not exert a negative impact on the cardiovascular function and decreased the incidence of hemorrhagic complications.
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PMID:[Variants of the use of hemosorption in patients with acute clofelin poisoning]. 917 31