Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lasalocid and monensin are widely used to control coccidiosis in broilers, but not in turkey poults. Four feeding trials were conducted to determine the performance of turkey poults when these compounds were used singly or in combination with 100 ppm of furazolidone. Bodyweights and feed consumption were significantly depressed for five weeks after hatching by 150 ppm of lasalocid. Combining furazolidone with lasalocid ameliorated the toxic effect of lasalocid. Bodyweights were significantly depressed by 150 ppm of monensin in the fifth week after hatching, but there was no significant depression in feed consumption. Furazolidone exacerbated any toxic effects of monensin. Data indicate that monensin may be used safely at dosages greater than the recommended level of 60 to 99 ppm, but should not be used in combination with furazolidone.
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PMID:Effect of including lasalocid or monensin singly or in combination with furazolidone on the growth and feed consumption of turkey poults. 226 13

Piglets which were early-weaned at the age of 21.7 days and experimentally monoinfected with oocysts of Isospora suis showed distinct reductions in zootechnical criteria during an experimental period of 4 weeks. The daily liveweight gains in the infected piglets (group B) was 19.7% lower than in the control group A, which was free of Coccidia. Comparative photographs with the REM showed serious lesions in the small intestine of infected piglets, which are thought to be mainly responsible for the reduced productivity. The application of 150 mg Lasalocid per kg of total feed to infected piglets caused the rate of weight gain to attain the same values as the noninfected controls (group A). Piglets receiving Lasalocid treatment passed oocysts with the faeces which were infectious. On the other hand, infected piglets which were treated with 6 mg Halofuginone per kg of total feed did not contain any oocysts in the faeces. Despite having a higher liveweight at the beginning of the experiment, this group only gained as much liveweight as the infected piglets (group B). This depression in liveweight gains could be explained by the significantly reduced uptake of feed, which was 21.1% lower than in the controls (group A). 6 weeks after the first infection, a re-infection resulted in the appearance of oocysts in the faeces of the piglets which had been treated with Halofuginone. On the other hand, the animals treated with Lasalocid had developed an efficient immunity to Isospora suis.
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PMID:[The development of weaned piglets experimentally infected with Isospora suis as a model for the effect of lasalocid and halofuginone on coccidia (author's transl)]. 722 36

Lasalocid was given to horses in a series of sequentially increasing single oral doses ranging between 5 and 30 mg/kg of body weight, with an appropriate washout period between treatments. One of the 5 horses died after a dosage of 15 mg/kg, 1 of 3 horses died after 21 mg/kg, 1 of 3 horses died after 22 mg/kg, and 1 of 2 horses died after 26 mg/kg. The LD50 of lasalocid for horses was estimated to be 21.5 mg/kg. Monensin was given to horses in a similar manner at dosages of 1, 2, and 3 mg/kg of body weight. One of the 2 horses died after a dosage of 2 mg/kg and 1 horse died after a dosage of 3 mg/kg. The clinical signs of toxicosis observed in horses given either drug were progressive and included depression, ataxia, paresis, and paralysis with partial anorexia. Intermittent profuse sweating was observed before death in horses given monensin.
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PMID:Toxic effects of lasalocid in horses. 727 Oct 10