Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Presents a short biography of one of the winners of the American Psychological Association's Award for Distinguished Scientific Early Career Contributions to Psychology. The 2012 winner is Angela J. Grippo for her creative contributions in investigating the association between depression and cardiovascular disease in preclinical animal models. Using sophisticated behavioral and neuroscience methods, Grippo found changes in sympathetic tone, immune system activation, and serotonin levels, as well as increased susceptibility to life-threatening arrhythmias, in a rodent model of depression, changes similar to those observed in humans with depression and heart disease. Her research illustrates how animal models of physiology and behavior advance understanding of the connections among depression, stress, and physical disease in humans. Grippo's Award citation and a selected bibliography are also presented here.
 ...
PMID:Angela J. Grippo: Award for Distinguished Scientific Early Career Contributions to Psychology. 2316 43

Presents a short biography of the 2012 winner of the American Psychological Association's Award for Distinguished Professional Contributions to Applied Research. Leslie S. Greenberg is an exemplary scientist-practitioner whose pioneering work has significantly altered the landscape of the field of psychotherapy research and practice. His seminal research program has addressed basic questions regarding the significance of empathy, the therapeutic alliance, and emotion in human functioning. Greenberg's sophisticated task-analytic research method, used to empirically test processes of change occurring within psychotherapy, has allowed researchers to build models of how people in individual therapy resolve self-criticism, let go of unresolved anger and hurt from past emotional injuries, and resolve conflict in marital therapy. Greenberg has made a substantial impact through the development of a new therapeutic approach called emotion-focused therapy, an evidence-based treatment for both depression and couples' distress. Greenberg's Award citation and a selected bibliography are also presented here.
 ...
PMID:Leslie S. Greenberg: Award for Distinguished Professional Contributions to Applied Research. 2316 63

Paul Greengard was born in New York City in 1925. After completing high school, he served three years in the US Navy during World War II and then completed his bachelor's degree at Hamilton College where he majored in physics and mathematics. He obtained a PhD in biophysics from Johns Hopkins University in 1953 and pursued postdoctoral training with Wilhelm Feldberg at the National Institute for Medical Research in England. After eight years as head of biochemistry at Geigy, and sabbaticals at Albert Einstein College of Medicine and Vanderbilt University, he joined the Yale University faculty as a full professor of pharmacology in 1968. While he was at Yale, Greengard's laboratory performed groundbreaking research, which demonstrated a role for cyclic nucleotides, protein kinases and protein phosphatases, and their protein substrates in the regulation of synaptic transmission. In 1983, Greengard moved to The Rockefeller University, where he has since served as the Vincent Astor Professor and Head of the Laboratory of Molecular and Cellular Neuroscience. Greengard's paradigm-shifting research has continued at Rockefeller and has informed our understanding and possible treatment of a host of brain disorders, including schizophrenia, Alzheimer's disease, Parkinson's disease, and depression. He is the author of more than 950 research articles and reviews. Greengard has received numerous awards and honors, including the Nobel Prize in Physiology or Medicine in 2000, the Metropolitan Life Foundation Award for Medical Research, The National Academy of Sciences Award in Neuroscience, the Ralph W. Gerard Prize in Neuroscience for the Society for Neuroscience, and the Karolinska Institutet's Bicentennial Gold Medal. He is a member of the US National Academy of Sciences and the Institute of Medicine of the National Academies. The following interview was conducted on May 29, 2012.
 ...
PMID:A conversation with Paul Greengard. Interview by Eric J Nestler. 2329 5

Irving W Wainer, Senior Investigator in the Intramural Research Program at the National Institute on Aging/NIH received his PhD degree in chemistry from Cornell University and did postdoctoral doctoral studies in molecular biology (University of Oregon) and clinical pharmacology (Thomas Jefferson Medical School). He worked for the US FDA and held positions at St Jude's Children's Research Hospital, at McGill University as Professor in the Department of Oncology, and as a Professor of Pharmacology at Georgetown University. Wainer has published over 350 scientific papers, 10 books, 25 book chapters and holds 11 patents. His awards include: 'A.J.P. Martin Medal' presented by the Chromatographic Society; Doctor HonorisCausa awarded by the Medical University of Gdansk (Gdansk, Poland, 2006), Doctor HonorisCausa awarded by the Department of Medicine, University of Liege (Liege, Belgium, 2012), and the 2013 Eastern Analytical Symposium Award for Outstanding Contributions to the Fields of Analytical Chemistry. Wainer's research includes the development of new therapeutic agents for the treatment of congestive heart failure, cancer, pain and depression, many of which are in the later stages of drug development. His laboratory has also continued the development of cellular membrane affinity chromatography technology, and recent work includes the development of columns containing immobilized forms of the breast cancer resistance protein found in cellular and nuclear membranes and mitochondrial membrane columns. Wainer's laboratory has also continued its study of the effect of disease progression and aging on drug metabolism in critically ill and terminal patients. Interview was conducted by Lisa Parks, Assistant Commissioning Editor of Bioanalysis.
...
PMID:Interview with Irving W Wainer. 2393 28

Vivien Thomas (1910-1985) was an African-American scientist, pioneer, and renowned educator. Thomas's contributions to cardiovascular surgery were unequivocal, and yet it was only after his death that he gained more widespread recognition. Thomas's more notable work involves aiding in the discovery of the cause of traumatic shock, designing and guiding the first operation to treat Tetralogy of Fallot, carrying out the first atrial septectomy, and helping develop the electrical defibrillator. Thomas struggled amidst the adversities of racism and the Great Depression (1929-1941), armed merely with a high school degree. Nevertheless, his genius and determination eventually led him to receive an honorary doctorate from John Hopkins University. His story inspired the creation of the award winning PBS documentary in 2003 Partners of the Heart and also the 2004 Emmy Award-winning HBO film Something the Lord Made. This article will aim to provide an overview to the more notable events in Thomas's amazing tale, with a particular focus on his work on the Tetralogy of Fallot.
 ...
PMID:Vivien Thomas (1910-1985): the backstage pioneer and educator. 2435 50

This paper consists of reflections in relation to how follow-up is organized in the growing population of cancer survivors. It also includes focus on late effects in cancer patients. The paper also highlights research contributions in the area of depression in cancer patients and discusses these findings in relation to the daily clinical practice. Parts of this paper were a lecture given as a humble response to the Arthur M. Sutherland Award 2014.
 ...
PMID:Psychosocial cancer research - late career perspectives: the International Psycho-Oncology Society 2014 Sutherland Award lecture. 2607 33

Environmental factors acting during development of an individual may influence future health and disease susceptibility. Stressors, including altered diet, psychosocial stress, and immune challenge, during gestation can have negative consequences on the intrauterine environment and increase disease susceptibility of the developing fetus. The long-term effects on offspring have been observed in humans and include greater susceptibility to psychiatric disease, such as depression and anxiety disorders, and adverse metabolic conditions including obesity, diabetes and cardiovascular disease. Studies in my laboratory use rodent models and incorporate a multilevel approach to determine the behavioral, physiological, and neurobiological correlates of disease development as a consequence of early life stressors. The road I took in developing this research program was a rather circuitous one and navigating that path would not have been possible without the many mentors, colleagues, fellows and students who provided critical support. Although my name appears on the plaque of the Alan N. Epstein Research Award, I share this with all those I had the privilege of working with along that road, as briefly summarized in this article.
...
PMID:Developmental and environmental influences on physiology and behavior--2014 Alan N. Epstein Research Award. 2629 Dec 66

Utilization of patient-reported outcome measures (PROs) had been limited by the lack of psychometrically sound measures scored in real-time. The Patient Reported Outcomes Measurement Information System (PROMIS) initiative developed a broad array of high-quality PRO measures. Towards reducing the number of items administered in measuring PROs, PROMIS employs Item Response Theory (IRT) and Computer Adaptive Testing (CAT). By only administering questions targeted to the subject's trait level, CAT has cut testing times in half(1). The IRT/CAT implementation in PROMIS is unidimensional in that there is a separate set of questions administered for each measured trait. However, there are often correlations among traits. Multidimensional IRT (MIRT) and multidimensional CAT (MCAT) provide items concerning several correlated traits, and should ameliorate patient burden. We developed an MIRT model using existing PROMIS item banks for depression and anxiety, developed MCAT software, and compared the efficiency of the MCAT approach to the unidimensional approach. Note: Research reported in this publication was supported in part by the National Library of Medicine of the National Institutes of Health under Award Number R01LM011962.
...
PMID:Utilizing Multidimensional Computer Adaptive Testing to Mitigate Burden With Patient Reported Outcomes. 2695 63

Studies over the last 20 years have demonstrated that increased inflammation and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis are two of the most consistent biological findings in major depression and are often associated: but the molecular and clinical mechanisms underlying these abnormalities are still unclear. These findings are particularly enigmatic, especially considering the accepted notion that high levels of cortisol have an anti-inflammatory action, and therefore the coexistence of inflammation and hypercortisolemia in the same diagnostic group appears counter-intuitive. To celebrate the 2015 Anna-Monika Foundation Award to our laboratory, this review will discuss our own 20 years of research on the clinical and molecular evidence underlying the increased inflammation in depression, especially in the context of a hyperactive HPA axis, and discuss its implications for the pathogenesis and treatment of this disorder.
 ...
PMID:Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. 2847 11

The purpose of this study was to examine the relationship between physical fitness and psychological well-being, stress, and depression in Korean adults. Participants were 160 adults aged 40-70 years living in the metropolitan area of Incheon. Results were collected from random sample of main measurements from Incheon fitness center of National Fitness Award Project (2019). We assessed participants using physical fitness test (national fitness award), Psychosocial well-being index short form, Perceived Stress Scale, Geriatric Depression Scale. The data were analyzed Pearson and Spearman rank correlation analysis, and linear was conducted using IBM SPSS Statistics ver. 25.0. The re-sults indicated there were statistically significant associations between psychological well-being and agility, quick response; stress and flexibil-ity; depression and strength endurance strength, body fat. In addition, analysis showed that strength, endurance strength, body fat of physical fitness factors could significantly predict depression, flexibility could significantly predict stress, agility and quick response could significant-ly predict psychological well-being.
 ...
PMID:Correlation of physical fitness with psychological well-being, stress, and depression in Korean adults. 3291 40


<< Previous 1 2