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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of eperisone and afloqualone have been compared with those of tizanidine on excitatory responses of spinal dorsal horn neurones, evoked by noxious and innocuous peripheral stimuli. Tizanidine, administered intravenously or iontophoretically, resulted in a profound, long-lasting and selective depression of the responses to noxious stimuli. In contrast, intravenous injection of eperisone produced either a rapidly reversible depression of responses to both noxious and innocuous stimuli or had no effect on these responses. Iontophoretic administration of eperisone also reduced neuronal responses to both forms of peripheral stimuli and that induced by quisqualate. This depressant action of eperisone was rapidly reversible but was often accompanied by a reduction of the amplitude of the action potentials. Afloqualone had no depressant action on any evoked response when administered iontophoretically. However, intravenous injection of this agent resulted in weak depressant effects on responses to noxious, innocuous or both types of stimuli, of a few of the neurones tested. This effect of afloqualone was not dose-dependent and was mimicked by control injections of the vehicle in which it was suspended. It is suggested that the muscle relaxants, eperisone and afloqualone, in contrast to tizanidine, do not possess any direct spinal antinociceptive activity.
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PMID:Effects of tizanidine, eperisone and afloqualone on feline dorsal horn neuronal responses to peripheral cutaneous noxious and innocuous stimuli. 261 16

In gross-behavioral observations, chlordiazepoxide, diazepam, meprobamate, and pentobarbital-Na produced excitatory behavior at 5 and 10, 1 and 2, 100 and 200, and 10 and 20 mg/kg p.o., respectively whereas afloqualone produced no excitatory behavior at doses up to 20 mg/kg p.o., these doses induce muscle relaxation and motor depression. Afloqualone depressed DRL response at 10 and 20 mg/kg p.o. Similar effects were seen with chlorpromazine (5, 10, 20 mg/kg p.o.). Chlordiazepoxide, meprobamate, and pentobarbital-Na facilitated DRL response at doses producing excitatory behavior. Methamphetamine (0.5, 1, 2 mg/kg p.o.) facilitated the response, dose-dependently. In CER, chlordiazepoxide (5, 10, 20 mg/kg p.o.), diazepam (1, 2, 5 mg/kg p.o.), and meprobamate (50, 100, 200 mg/kg p.o.) dose-dependently increased the response during the alarm period, regardless of the response during the safe period. Pentobarbital-Na (5, 10, 20 mg/kg p.o.) had much the same effect. Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively. Chlorpromazine and methamphetamine had no influence on the response during the alarm period at doses up to 20 and 2 mg/kg p.o., respectively. These results suggest that the pharmacological properties of afloqualone, as related to behavior differ from those of anti-anxiety drugs, hypnotics, and stimulants.
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PMID:[Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl)]. 612 Jan 27