Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A double-blind crossover trial of Medazepam was carried out in 14 anxious hospital patients. The mean self-adjusted dosage was 16.5 mg daily. The active drug was no more effective than placebo in relieving anxiety, which was rated both clinically and by the Middlesex Health Questionnaire (M.H.Q.) (Crown and Crisp, 1970). This may have been because the dose was relatively low for chronically anxious hospital patients. Even this dosage caused significantly higher scores on the M.H.Q. scale for depression. Braking and driving simulator tests were not adversely affected by Medazepam. In real driving conditions those taking the drug made significantly more technical, but not dangerous, errors. Pulse and blood pressure also were not affected.
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PMID:Medazepam and the driving ability of anxious patients. 1 95

The effects of the benzodiazepine, medazepam, were investigated in current and voltage-clamped cultured chick dorsal root ganglion neurons. Under current clamp, micromolar concentrations initially elevated the action potential threshold and blocked both the sodium and calcium components of the spike. In voltage clamp, low (I(Ca.T)) and high (I(CA.N/L)) threshold calcium, sodium (I(Na)) and the delayed rectifier potassium (I(K)) currents were isolated by the use of appropriate solutions and voltage command protocols. Medazepam depressed both subtypes of I(Ca) equally well with calculated half-maximal depression at 77 microM. At a fixed concentration of 200 microM, medazepam depressed I(Na) (70 +/- 9%) and I(K) (73 +/- 6%) to a degree comparable to I(Ca) (75 +/- 3%). The results show that benzodiazepines can modulate the activity of several voltage-gated ion currents in chick dorsal root ganglion neurons.
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PMID:Effects of medazepam on voltage-gated ion currents of cultured chick sensory neurons. 244 93