Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1 Increases in renal blood flow were produced by intra-arterial injections of dopamine (5-50 mug) in anaesthetized dogs pretreated with alpha- and beta-adrenoceptor antagonists.2 Intra-arterial administration of ergometrine (0.5 mg) or apomorphine (1 mg) produced a depression of the renal dilator responses to dopamine, without affecting renal dilatations in response to intra-arterial acetylcholine (0.1-1 mug) or histamine (2-50 mug).3 The depression of dopamine responses lasted 10-15 min, and was greater with ergometrine than with apomorphine.4 It is concluded that both ergometrine and apomorphine can be used as specific blocking agents at vascular dopamine receptors. Ergometrine is the preferred drug for this purpose.
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PMID:Ergometrine and apomorphine as selective antagonists of dopamine in the canine renal vasculature. 445 34

Ergometrine (ergonovine) tests were performed in patients with unstable angina on the 1st day of hospitalization, on 2nd--3rd days during which patients received only nitroglycerin sublingually for acute pain relief (33 observations), and after "stabilization" of their condition by calcium antagonists or/and beta-blockers (34 observations). Reactions to ergometrine were classified as spastic when pain was accompanied by ST segment elevations of T wave changes and as nonspecific when intravenous ergometrine resulted in ST segment depression and/or anginal attack. Spastic reactions to ergometrine observed in the acute period as a rule disappeared with "stabilization" of patients condition. Spontaneous rapid disappearance of spastic reactions was noted in 4 of 15 patients. Spastic reactions also disappeared in 13 of 17 patients while they were on active antianginal therapy. Disappearance of spastic reactions was observed more frequently in patients treated with calcium antagonists than with beta-blockers. Nonspecific reactions never disappeared spontaneously. Persisting despite therapy any positive reaction to ergometrine was prognostically unfavorable.
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PMID:[Unstable angina pectoris: results of repeated ergometrine tests]. 709 72