Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2-(2,6-Dichlorphenylamino)-(clonidine, Catapresan, Catapres), 2-(2,6-diethylphenylamino- (St 91), 2-(2-chloro-6-methylphenylamino)-, 2-(2-chloro-4-methylphenylamino)-, 2-(2-methyl-5-fluorophenylamino) -and 2-(2-chloro-3-methyl-phenylamino)-2-imidazoline were investigated in various pharmacological tests. 1. All substances increased blood pressure in spinal rats and initially in intact cats and dogs and increased the total peripheral resistance in the latter. As these compounds also showed mydriasis in conscious rats it has been concluded that these effects are due to stimulation of peripheral alpha-adrenoceptors. 2. With the exception of St 91 the substances lowered blood pressure following i.v. injection, they decreased heart rate in cats and dogs and the cardiac output in the latter. These four compounds also decreased heart rate in vagotomised and atropinised rats. It was concluded that these effects were due to a decrease in sympathetic activity of the CNS. 3. In anaesthetised rats with beta-adrenoceptor blockade by toliprolol, a blood pressure increase was elicited by i.v. injection of angiotensin and the resulting bradycardia was recorded as a measure of vagal reflex activity. Clonidine and three derivatives which have shown hypotensive activity facilitated the vagal cardiodepressor reflex; St 91 was inactive in this respect. It has been concluded that decrease in central sympathetic tone and increase in central vagal activity are linked together in these compounds. 4. St 91 did not lower blood pressure and did not facilitate vagal reflex bradycardia after i.v. injection in dogs, but was active after intracisternal injection. It has been concluded, therefore, that this compound is able to act on structures in the CNS like clonidine but these effects usually do not occur after systemic administration because of its poor ability to penetrate the blood-brain barrier. 5. All derivatives decreased gastric acid secretion. 6. All substances increased blood glucose levels and were sedative; St 91 was the least effective compound in both respects pointing to a central mediation of these effects. 7. The results show that clonidine and the derivatives tested have the same reaction pattern. 8. The relationship between the CNS mediated cardiovascular depression and the peripheral alpha-adrenergic stimulating potency in conjunction with the lipoid solubility have been discussed.
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PMID:Relationship between activity and structure in derivatives of clonidine. 124 25

Clonidine hydrochloride, administered intravenously (2 micrograms/kg) during the second non-rapid eye movement period, was significantly less suppressant of rapid eye movement sleep in 10 depressed patients with primary major affective illness, according to Research Diagnostic Criteria, than in three groups of matched subjects (10 normal controls, 10 patients with minor depression, and 10 patients with generalized anxiety). These results suggest that depressed patients with major primary affective illness have down-regulated alpha 2-adrenergic receptors. These findings are consistent with the cholinergic-aminergic balance hypothesis of depression and support the aminergic side of the concept. Finally, the rapid eye movement sleep response to clonidine could provide a new biological marker of affective illness.
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PMID:Reduced clonidine rapid eye movement sleep suppression in patients with primary major affective illness. 132 19

DADL was administered to a patient who was analgetically tolerant to continuously infused, intrathecal morphine sulfate. DADL restored analgesia without respiratory depression but opiate withdrawal syndrome was not prevented. Somnolence, not responsive to naloxone but completely reversed with morphine, was seen as an idiosyncratic mu receptor opiate withdrawal symptom. Clonidine hydrochloride and decreasing doses of oral morphine were used to successfully treat the withdrawal syndrome, including somnolence. Further research is indicated to verify the findings of this one patient and investigate the efficacy of DADL to provide analgesia for morphine-tolerant patients.
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PMID:Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate. 300 62

Clonidine hydrochloride (CH) is an antihypertensive drug with complex pharmacologic activity including central and peripheral alpha-adrenergic stimulation and CNS depression. We reviewed the records of 5 children admitted to our Pediatric Intensive Care Unit following accidental ingestion of CH. All patients presented with lethargy or stupor, beginning 20-60 minutes after ingestion. Respiratory depression or apnea occurred in 4, requiring endotracheal intubation in 2 and mechanical ventilation in 1. All 5 developed mild to moderate hypertension, and 3 developed asymptomatic bradycardia. The dose of CH ingested was estimated to be 0.2-0.4 mg in 4 out of 5 patients. Treatment consisted of efforts to prevent absorption of CH from the GI tract and supportive care. All signs of CH toxicity resolved within 6-14 hours. Four patients were transferred from ICU within 24 hours and discharged home the following day. One patient developed post-extubation stridor and atelectasis. Significant toxicity occurred even though the amount of CH ingested was relatively small in at least 4 or 5 patients. Transient hypertension occurred early in the hospital course of all patients and resolved without treatment. Hypotension and symptomatic bradycardia were not observed. Apnea was the most serious abnormality observed. All patients recovered without significant morbidity.
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PMID:Hypertension associated with clonidine ingestion. 652 27

Clonidine hydrochloride poisoning in children has become more frequent with increasing availability of this drug. We report four cases of accidental clonidine poisoning that demonstrate the various signs and symptoms of clonidine poisoning. The most frequent and significant toxic effects are depression of consciousness, bradycardia, hypotension, and respiratory depression. Ventilatory support must be available if apnea occurs. Bradycardia can be treated with atropine sulfate, epinephrine chloride, dopamine hydrochloride, or tolazoline hydrochloride. Hypotension is treated with intravenous fluids and dopamine, reserving tolazoline for refractory cases. Hypothermia is common but is of minor clinical significance. Paradoxical hypertension should be treated with tolazoline. Clonidine may not be detected in body fluids by routine toxicology-screening procedures, so poisoning should be suspected on clinical grounds.
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PMID:Clonidine poisoning. A complex problem. 684 4