Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excitatory postsynaptic potentials (termed U1 and U2) were extracellularly recorded from the frog optic tectum in vitro following electrical stimulation of the contralateral optic nerve.
Gamma-Aminobutyric acid
(
GABA
) and glycine elicited a large and sustained enhancement of these synaptic waves. In the presence of the Cl- transport inhibitor ammonium (NH+4) the effects of
GABA
or glycine were progressively reduced to about 50% of their initial action without changes in the control synaptic waves. In 50% Cl- media the
depression
of
GABA
and glycine responses by NH+4 was more intense. Other Cl- transport inhibitors such as bumetanide, piretanide and 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulphonate (SITS) were inactive against responses to
GABA
or glycine. Penicillin, a Cl- channel blocker, antagonized the action of
GABA
and glycine, while increasing the amplitude of the U2 waveform. The present results provide pharmacological evidence in support of the Cl- dependence of the unusual action of
GABA
or glycine in facilitating excitatory synaptic transmission in the optic tectum.
...
PMID:The effect of GABA on the frog optic tectum is sensitive to ammonium and to penicillin. 216 48
