Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Beta-Endorphin (0.3 or 0.6 nanomoles) was infused into the A10-ventral tegmental area (VTA) of male Wistar rats previously treated for 6 days with either morphine sulfate or lactose via subcutaneously implanted silastic pellets. Beta-Endorphin microinfusions occurred at 24 and 96 hours after pellets were removed. Profound changes in locomotor response to beta-endorphin were found, with morphine-pretreated rats showing a spontaneous switch from hyporesponsiveness to hyperresponsiveness over 72 hours, compared to lactose-pretreated controls. These findings may reflect on current biochemical theories regarding the "switch" process in bipolar affective disease. The data can be viewed within a heuristic model of receptor changes which may underlie the transition from depression to mania.
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PMID:Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome--a proposal for a model of the onset of mania. 629 80

The production of extracellular 1,3-, 1,6-beta-glucanases and chitinase was studied during submerged cultivation of a Trichoderma viride strain 3/78 on various carbon sources: glycerol, glucose, lactose, sucrose, laminaran, starch, pustulan, chitin, and Agaricus bisporus fruit bodies. The synthesis of these enzymes and cellulase was studied also under the conditions of depression at low concentrations (10(-2) and 10(-3)M) of the first five aforementioned carbon sources as well as cellobiose, gentiobiose, N-acetyl-beta-D-glucosamine and 0.1% chitooligosaccharides and A. bisporus cell walls. The experiments were conducted with the washed mycelium of this strain grown for 2 days in a medium with glycerol as a carbon source. The results indicated that 1,3- and 1,6-beta-glucanases of the strain were of the constitutive nature and were repressed by such carbon sources as glycerol and glucose. Chitinase and cellulase were shown to be inducible enzymes. Chitinase was induced by N-acetyl-beta-D-glucosamine, chitooligosaccharides and A. bisporus cell walls as well as by lactose when the fungus was grown on this carbon source. Cellulase biosynthesis was induced by lactose, cellobiose and gentiobiose.
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PMID:[Beta-glucanase and chitinase biosynthesis in a culture of a mycophilic strain of Trichoderma viride]. 642 Jun 49

beta-Galactosidase concentrates obtained from several microorganisms were used to hydrolyze skim milk, low fat (2%) milk, sweet whey, acid whey, acid whey permeate, and acid whey concentrate. Among acid substrates, the freezing point depression for each 1% lactose hydrolyzed was the greatest with the lactase from Aspergillus niger (0.0501 degrees H); among neutral substrates, the depression was greater in sweet whey (0.0495 degree H) and lesser in low fat milk (0.0445 degrees H). All data were statistically significant. The average freezing point depression for each 1% lactose hydrolyzed wa s0.0468 degrees H (range 0.0436-0.0501 degrees H). Oligosaccharides formed in the lactose hydrolysis inconsistent freezing point readings of the cryoscope at the low freezing points measured, and protease contamination in some lactases may affect the precision of freezing point determination. Hydration and volume of non-protein components in commercial enzymes, unstable color complex formed by lactose and methylamine solution, and difficulty in the use of methylamine solution might cause variations in determination of lactose by the analytical procedure. These factors can be eliminated or minimized. This method is the simplest and quickest estimation of lactose hydrolysis, and it offers great accuracy and consistency.
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PMID:Estimation of lactose hydrolysis by freezing point measurements in milk and whey substrates treated with lactases from various microorganisms. 679 59

Mammary function in the conscious goat was studied during colchicine-induced depression of milk secretion in one mammary gland. Milk yield of the treated gland was reduced to approximately a quarter of previous, while there were significant increases in afternoon milk yield from the untreated glands on the 2nd and 3rd days after treatment in goats in late lactation. Milk composition in the untreated glands was not significantly affected. In the treated gland, milk [Na+], [Cl-], [citrate] and [protein] increased while [K+] and [lactose] decreased, although the time course of these changes differed; milk [fat] was unaffected. Mammary extractions ((A-V)/A) of glucose, acetate and most amino acids were significantly decreased during the period of maximal inhibition of secretion. There were no significant changes in arterial plasma concentrations of glucose, acetate or any essential amino acids. In another series of experiments, mammary blood flow increased and then returned to normal after colchicine treatment even though milk yield and mammary glucose uptake decreased markedly; oxygen uptake was not significantly affected. The results are discussed in relation to the actions of colchicine on the mammary secretory cell, to the normal control of mammary blood flow and to the mechanism of compensation by the untreated gland.
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PMID:The effects of colchicine on milk secretion, mammary metabolism and blood flow in the goat. 690 40

The 1-hour xylose absorption test was evaluated as method for the diagnosis of cows' milk protein-sensitive enteropathy in a prospective study of 48 infants with diarrhoea clinically suspected to be due to intolerance of cows' milk. The infants were maintained on a lactose and cows milk protein-free diet for 6-8 weeks and then were challenged with cows' milk protein. Jejunal biopsies and the 1-hour xylose absorption test were performed immediately before and 20-24 hours after cows' milk provocation. After milk provocation, 30 infants had clinical, enzymological, and histological relapse, and in 28 of them there was a significant depression of post-provocation blood xylose levels. Six infants had histological and enzymological relapse but clinically they tolerated cows' milk. The post-provocation blood xylose level was depressed in all infants. Ten infants had enzymological relapse without histological or clinical relapse. The post-challenge blood xylose was depressed significantly (greater than 20%) in 3, mildly depressed in 3 (16-18%), and not depressed in four. Two infants clinically, histologically, and enzymologically tolerated cows' milk; in each the post-challenge xylose was depressed (22%, 12%). It appears that the 1-hour blood xylose test is not as reliable as the jejunal biopsy in the diagnosis of cows' milk protein-sensitive enteropathy.
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PMID:One-hour blood xylose in the diagnosis of cows milk protein-sensitive enteropathy. 706 92

This study was designed to determine the critical difference between rat milk and rat chow with respect ot their effects on jejunal sucrase activity during the fourth postnatal wk. Rats were weaned onto special diets on postnatal day 17, and jejunal sucrase was assayed on day 28. A pelleted diet containing lactose as sole carbohydrate did not cause depression of sucrase activity. Sucrase values (micromoles/hr/mg protein) were 10.49 +/- 0.81 (n = 15) for the lactose chow and 6.65 +/- 0.29 (n = 16) for the sucrose chow. This indicates that the nature of the dietary carbohydrate does not account for the sucrase differences of weaned and nonweaned animals. Likewise, the physical consistency of the diet is unimportant because sucrase values were just as high on liquid diet (10.91 +/- 0.77 micromoles/hr/mg protein; n = 8) as on he solid diets. However, when the relative proportions of carbohydrate and fat in the diet were varied, there were significant effects on sucrase activity; values on a low carbohydrate diet (4.30 +/- 0.33 micromoles/hr/mg protein; n = 8) being less than one-half those on a high carbohydrate diet (10.91 +/- 0.77 micromoles/hr/mg protein; n = 8).
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PMID:Role of diet in the determination of jejunal sucrase activity in the weanling rat. 725 54

A series of putative anticarcinogenic and antimutagenic compounds was synthesized on the basis of tetraethylthiuram disulfide (disulfiram) and its metabolite, diethyldithiocarbamate (DDTC). Diallyldithiocarbamate was synthesized in order to combine the anticarcinogenic properties of diallyl sulfide, a known inhibitor of chemical carcinogenesis from Allium species, and those of DDTC. Several sugar-linked dithiocarbamates (SDTCs) were prepared using glucose, cellobiose, and lactose as glycosyl donors and DDTC and diallyldithiocarbamate as acceptors. All the S--glycoside bonds of SDTCs were very stable under physiological conditions in vitro. At low nitrosamine concentrations, glucose-DDTC inhibited microsomal nitrosamine dealkylases in vitro. In vivo these enzymes were also inhibited 4 h after i.p. administration of glucose-DDTC or lactose-DDTC to rats (1.7 mmol/kg); after 24 h, the values had returned to control levels. Glucose-DDTC induced the activity of glutathione-related enzymes. Concomitant treatment of rats with glucose-DDTC and N-nitrosodiethylamine (NDEA) led to a depression of the oxidative metabolism of [14C]NDEA to 14CO2 but increased the elimination of unchanged [14C]NDEA in the urine. Furthermore, glucose-DDTC totally inhibited the formation of DNA single-strand breaks induced by NDEA. All these effects may contribute to possible antimutagenic and anticarcinogenic actions of the dithiocarbamates investigated.
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PMID:Sugar-linked dithiocarbamates as modulators of metabolic and genotoxic properties of N-nitroso compounds. 793 39

Thirty-three political prisoners on hunger strike (voluntary total fast--VTF) for 6-24 days were admitted to two hospitals in Johannesburg in 1989. They had been detained without trial for 4-32 months. Sound doctor-patient relationships were established by emphasis of the principle of full patient participation in clinical decision-making at every level, by rejection of police interference in patient care, and by refusal to discharge subjects back into detention. Depression and abdominal pains were the predominant symptoms. In 6 lean subjects with complete data the expected initial period of rapid weight loss was not observed. Before hospitalisation most subjects became dehydrated from inadequate fluid intake and an apparent absence of thirst. Serum creatinine concentrations were a better indication of dehydration than serum urea levels. Mild hyponatraemia was found in one-third of patients. Refeeding after 6-27 days of VTF was initiated with a dilute lactose-free formula diet, and was uncomplicated. Close clinical monitoring of subjects during VTF is essential, and it is recommended that prisoners should be admitted to hospital at 10% of weight loss, if not before. The health care of prisoners can best be provided by professionals independent of the police and prison services.
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PMID:Voluntary total fasting in political prisoners--clinical and biochemical observations. 821 48

The effects of transgalactosylated disaccharide (TD) intake on human fecal microflora and their metabolism were investigated in 12 Japanese males. TD is a mixture of sugars, galactosyl galactose, and galactosyl glucose, synthesized from lactose through the transgalactosylation reaction of Streptococcus thermophilus beta-galactosidase. Volunteers took 15 g of the test sugar daily for 6 days. The TD ingestion increased the number of bifidobacteria and lactobacilli, but decreased the number of Bacteroidaceae and Candida spp. in the feces. The ratio of bifidobacteria to total bacteria increased from 0.28 to 0.51. TD decreased the fecal concentrations of propionic acid, isobutyric acid, isovaleric acid, and valeric acid. This sugar also lowered the fecal pH, and the concentrations of fecal ammonia, p-cresol, and indole. Moreover, a positive correlation was found between the concentration of ammonia, and that of branched-chain fatty acids (isobutyric acid and isovaleric acid), p-cresol, and indole. All of these compounds are produced from amino acids through deamination by the intestinal bacteria. The depression of amino acid fermentation by intestinal bacteria may be involved in the reduction of fecal ammonia. These results suggest that a part of the transgalactosylated disaccharides passes into the colon, inducing changes in the colonic microflora composition, hastening carbohydrate fermentation, and depressing amino acid fermentation in the human gut.
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PMID:Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism. 822 19

Metabolic and endocrinological characteristics were compared for cows that differed in the extent of milk fat depression. Forty-one multiparous Holstein cows were fed control (40% concentrate and 60% forage) and high concentrate (80% concentrate and 20% forage) diets in a doubale-reversal design. Cows showing one or more percentage units of depression in milk fat were arbitrarily classified as responders (n = 26); those remaining were classified as nonresponders (n = 15). Compared with nonresponders, responders had greater increases in DMI, estimated NEL intake and balance, BW, milk yield, protein and lactose yields in milk, weight percentage of trans-C18:1 fatty acids in milk, and concentrations of triiodothyronine and thyroxine in serum when switched from the control diet to the 80% concentrate diet. Lack of an increase in concentrations of glucose and insulin in serum of cows with the greatest decline in percentage of milk fat casts doubt on the ability of the glucogenic theory to explain milk fat depression completely.
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PMID:Milk fat depression, the glucogenic theory, and trans-C18:1 fatty acids. 855 Sep 10


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