Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In early 1975, surprising therapeutic effects of baclofen (Lioresal) in patients suffering from severe, chronic schizophrenia were reported from Sweden. We have carried out a study in 24 similar cases which we treated with baclofen in dosages up to 25 mg t.i.d. In rougly half of these patients no effect was observed. Of the remainder, four showed some improvement and another four a further deterioration of their condition. Those responding well were patients with acute symptoms or a history of depression, while in some of those whose condition worsened catatonic symptoms had been noted. This therapeutic possibility appears interesting from both the scientific and the practical points of view. The new class of substances merits further investigation to evaluate its psychopharmacological activity.
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PMID:[Neuroleptic effect of baclofen in chronic schizophrenia (author's transl)]. 98 12

Cardiac conduction abnormalities and hypertension developed in a patient who ingested approximately 500 mg of baclofen (Lioresal). The patient also exhibited the more common features of baclofen overdose including coma, respiratory depression, hypotonia, and hyporeflexia. A review of the literature and a discussion of the interesting manifestations and treatment of baclofen overdose are included.
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PMID:Baclofen overdose with cardiac conduction abnormalities: case report and review of the literature. 301 74