Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Analytical approaches to Burning Mouth Syndrome permit the suggestion that it is a symptom of hidden depression, where the depressive process and its two major indicators (vital sadness and psycho-motor slowing down) are totally or partially concealed by a somatic symptomatology which can strike down any system: vaso-vegetative, cardio-vascular, gastro-intestinal, genito-urinary, muscles and skeleton. 2. Depression is a mental process, part of normal psychic development, which must be overcome at least once in a lifetime in order to reach the status of an autonomous being. Hidden depression is one form of pathological depression, which expresses an inability to (i) mentalize depression, separation, and (ii) become an autonomous being. 3. Burning mouth is a symptom resulting from complex dynamics, from hysterical conversion to the inability to mentalize separation, both with underlying fault in the "narcissistic nucleus" (a term meaning the sense of identity originating in the motherly holding, in the skin to skin touch). 4. Treatment will be a combination of anti-depressive drugs and psychotherapy, drugs being prescribed by the practitioner, and psychotherapy conducted by a therapist with an analytical background.
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PMID:[Burning mouth syndromes and depression. A psychoanalytic approach]. 892 32

This research has been conducted on the basis of the association between a psychogenic factor and stomatopyrosis as its consequence. Stomatopyrosis is characterized as a burning sensation or as pain in the mouth cavity with clinically normal oral mucosa. It typically occurs with elderly female population, aged on average 67. Burning mouth as a symptom occurs primarily on the lips, although it may be located on some other sites on the oral mucosa. There are various etiological factors influencing the emergence of stomatopyrosis. They are divided into local factors, related to candidiasis, dysfunction, problems caused by dentures; systemic factors, with hormonal or immunological disturbance, medicines, etc; and, finally, psychogenic factors, characterised by various psychological states and conditions like depression, anxiety, adaptability and emotional stability. The objective of this research was to prove that psychogenic factors cause the burning mouth syndrome sensation. Methods which helped us to establish the link between psychogenic factors and the emerging of stomatopyrosis were general history of the respondents, clinical history, which included both objective and subjective assessment, and psychological rating scales and tests. The results have shown that sex of the respondents does not make any difference. Diagnosis of the oral disease shows that burning is the symptom as well as in the diagnosis of the disease, that localisation of the symptom is primarily on lips, followed by tongue, cheeks, and palate. The description of the symptoms shows that respondents with stomatopyrosis complain of burning and dryness in the mouth cavity. As far as the intensity of the symptom is concerned, the results have shown that the symptom is in most cases unbearable. The frequency of the occurrence of the symptoms said to be continuous. The typical time when the symptom occurs is daytime, followed, by night and evening, day and night. Tension dentures and hot food intensify the symptom. Subjective change in taste is present in the high percentage. Visual analogue scale shows a high degree subjective assessment of the symptoms in the mouth cavity. Thermoestesiometry has established that there are no pathological changes on the oral mucosa. Psychological rating scales and tests have established the presence of psychical changes in a high percentage. What we took into account were the most frequent changes: depression, anxiety, adaptability and emotional stability. We also established a systematic and a psychiatric diagnosis that was necessary for making the right choices when treating people with stomatopyrosis. Stomatopyrosis is the state whose factor, apart from local and systematic factors, may be psychogenic factor. We think that stymatopyrosis may be psychosomatic state that can be cured or treated by appropriate treatment, which includes psychiatric treatment as well.
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PMID:Psychogenic factors in the aetiology of stomatopyrosis. 1094 75

Patients with symptoms allegedly caused by abnormal sensitivity to dental fillings and/or to electromagnetic fields and other environmental factors frequently report oral complaints. Forty-four consecutive patients with these symptoms were studied. The aim was to investigate whether unstimulated salivary flow rate was associated with Candida, symptoms, disease, medication, age, sex, anxiety, depression, and stress. Furthermore, the aim was to compare the level of anxiety, depression, and stress in these patients with an age- and sex-matched control group. Fifty percent had no or low flow rate from the minor salivary glands. Candida pseudohyphae were found in 50% of the patients. Hypothyroidism and/or intake of thyroid hormones, headache, fatigue, and age were negatively associated with unstimulated salivary flow rate, and dizziness was positively associated. Unstimulated salivary flow rate was positively associated with stimulated salivary flow rate and flow rate from the minor salivary glands. Burning mouth and subjective oral dryness were reported by 48%, and 46%, respectively. The patients were more anxious, stressed, and especially more depressed than the control group. Unstimulated salivary flow rate was negatively associated with state anxiety. Measurement of salivary flow rate is important in patients with environmental illness and can be used in combination with other measurements as a diagnostic tool.
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PMID:Environmental illness: evaluation of salivary flow, symptoms, diseases, medications, and psychological factors. 1137 Jul 47

Burning mouth syndrome is characterized by a burning sensation in the tongue or other oral sites, usually in the absence of clinical and laboratory findings. Affected patients often present with multiple oral complaints, including burning, dryness and taste alterations. Burning mouth complaints are reported more often in women, especially after menopause. Typically, patients awaken without pain but note increasing symptoms through the day and into the evening. Conditions that have been reported in association with burning mouth syndrome include chronic anxiety or depression, various nutritional deficiencies, type 2 diabetes (formerly known as non-insulin-dependent diabetes) and changes in salivary function. However, these conditions have not been consistently linked with the syndrome, and their treatment has had little impact on burning mouth symptoms. Recent studies have pointed to dysfunction of several cranial nerves associated with taste sensation as a possible cause of burning mouth syndrome. Given in low dosages, benzodiazepines, tricyclic antidepressants or anticonvulsants may be effective in patients with burning mouth syndrome. Topical capsaicin has been used in some patients.
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PMID:Burning mouth syndrome. 1187 78

Burning mouth syndrome (BMS) is a complex disease of unknown cause. It is characterized by a burning sensation in the oral mucosa, notwithstanding its clinical normal aspect. BMS is particularly seen in postmenopausal women. The purpose of this study was to investigate this syndrome on a clinical basis and, in addition, to analyze its possible relation to the frequency of Candida species. Thirty-one patients (28 women and 3 men; 13 Caucasians and 18 non-Caucasians; mean age = 61.3, range 30-85 years) were evaluated. Most patients (80.6%) were under long-term medication, antihypertensive, ansiolitic and antidepressant drugs being the most used. Burning mouth complaint was associated with other secondary oral complaints in 83.8% of the cases. Tongue was the most commonly affected site (70.9%), followed by the vermillion border of the lower lip (38.7%) and hard palate (32.2%). The association of the burning sensation with oral cancer (cancer phobia) was reported by 67.7% of the patients. Haematologic examination (hematocrit, haemoglobin and fasting blood glucose level) revealed 2 cases each of anemia and type 2 diabetes. Local factors, tooth extractions and dentures wearing, were associated with the onset of symptoms in 35.5% of the cases. Daily activities were changed as a consequence of BMS in 29% of the patients. Among the species of the genus Candida, C. albicans was the most frequent in BMS patients (9 - 29.03%) and controls (12 - 38.70%), followed respectively by C. parapsilosis (2 - 6.45% and 0 - 0%); C. tropicalis (1 - 3.22% and 2 - 6.45%); C. krusei and C. kefyr (1 - 3.22% and 0 - 0%). Therefore, such difference did not reach valuable results. In conclusion, these data were similar to those reported in other studies. The highlights of the present findings were the possible relation of BMS with chronic drug use, depression, menopause and cancer phobia. No association was found between BMS and the prevalence of Candida species.
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PMID:Burning mouth syndrome: clinical profile of Brazilian patients and oral carriage of Candida species. 1827 6

Stomatopyrosis of 'burning mouth' syndrome, in a narrower sense of definition, is a condition characterized by sensation of burning and heating in mouth, despite its normal mucosa. This research has been directed towards treatment of stomatopyrosis, putting emphasis on the implementation of psychopharmacotherapy and psychotherapy. The research was conducted on altogether 120 respondents suffering from stomatopyrosis. The respondents were divided into two equal groups: each one comprising 60 members. All the respondents were treated by means of a standard topical therapy. All the patients were assessed clinically and by means of psychological tests measuring depression and anxiety four times: once before the treatment, after one month, after two months and after four months since the beginning of the treatment. The acquired data were afterwards statistically processed. Our research led to the conclusion that stomatopyrosis occurs with elderly people, primarily women. Regarding their occupation, majority of the respondents were clerks, followed by retirees. The burning sensation in mouth was present with all the respondents, the dominating site being the lips, while the nature of sensation was reported as mostly unbearable. Anxiety, tension and stress tend to aggravate the symptoms. When grading the symptoms on VAS, i.e. visual analogous scale, the subjective assessment of symptoms was marked as 7-8 cm, which shows a high degree of burning sensation. According to our study, the quantity of saliva, which was at the beginning of the research slightly decreased, normalized after the treatment. Apart from the clinical investigation of stomatopyrosis, we applied Depression and Anxiety questionnaires. During the therapy, the results of the depression test have shown a decrease in depression (from 56.7% to 0.00%), which is particularly apparent in the group treated by autogenic training and in the first group of respondents, i.e. the one treated with antidepressants. The Anxiety tests have shown a higher percentage and intensity of anxiety with men (62.5%, as opposed to women - 32.5%) in the beginning, which has dropped to 7.5% with men during the treatment and 8.8% with women. Clinical presentation of stomatopyrosis has also apparently improved. This improvement in clinical symptoms and psychological condition of patients is statistically significant. On the basis of our research, we have concluded the following: the comorbidity of stomatopyrosis with the phenomena of anxiety and depression proves that, among other factors, there is a psychogenic aetiology of this disease. Further research should provide answers to the questions whether stomatopyrosis is a psychosomatic or a conversive disorder Antidepressants and anxiolytics have an important role in the therapy of stomatopyrosis. Autogenic training, which is a psychotherapeutic anxiolytic technique, is a therapy of choice for stomatopyrosis, which contributes not only to the elimination of oral complaints, but to the emotional rehabilitation of the patients as well.
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PMID:Regression analysis of the symptoms. 1940 18