Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Psychosocial factors have been frequently suggested as important risk factors that may delay recovery in patients with temporomandibular disorders. In this study, 94 subjects with chronic temporomandibular disorders were studied using IMPATH:TMJ prior to their entering an interdisciplinary treatment program to determine which factors were most predictive of outcome. Treatment outcome was determined based on significant decreases in the Craniomandibular Index and the Symptom Severity Index from pretreatment to posttreatment. The IMPATH:TMJ items were regressed on treatment outcome for a random sample of half of the subjects (n = 47) to isolate the psychosocial and demographic items most predictive of treatment response. Discriminant analysis was then employed to test the predictive utility of the identified items for these subjects (criterion group), followed by a cross-validation of the items on the remaining 47 subjects (cross-validation group). Low self-esteem, feeling worried, low energy, and sleep activity were identified as useful predictors of treatment outcome for the criterion group. Each are correlates of depression. The discriminant analysis employing these four items accounted for 49% of the variance in treatment response, was statistically significant (P < .0001), and correctly predicted treatment outcome for 41 of 47 subjects (87%) in the criterion group. The predictive utility of the identified items remained statistically significant when applied to the cross-validation group (P < .01). The discriminant function employing the items correctly predicted treatment outcome for 37 of 47 subjects (79%) and explained 28% of the variance in treatment response. Findings of this study suggest that pretreatment psychosocial information is important in predicting treatment outcome for chronic temporomandibular disorders, and that symptoms of depression mediate treatment response for chronic pain patients.
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PMID:Predictors of outcome for treatment of temporomandibular disorders. 899 17

Genetic testing for cancer susceptibility (e.g. hereditary non-polyposis colorectal cancer) is available for some families with a history of colon cancer. Our aim was to investigate participants' anticipated emotional and behavioral reactions to genetic testing for colon cancer and whether gender or clinical risk influences these reactions. 437 asymptomatic participants with a colorectal cancer family history completed a questionnaire about anticipated emotions and actions, under different genetic testing scenarios. More women than men anticipated feeling worried, regretful, and angry if tested positive. People at lower-risk anticipated more surprise and disbelief than those at higher-risk. People anticipated feeling more guilt, regret and less relief if they were not tested than if they were. High-risk results were anticipated to increase depression and worry. Most people still wanted screening if at low risk, anticipated leading healthier lifestyles whatever the result, but would make more plans for the future if they were at high risk. Clinical implications are that as anticipated emotional effects of not being tested may be more severe than having a test, people choosing to forgo testing should feel able to reconsider their decision anytime. Most people did not anticipate strong emotional reactions but thought it would change their lifestyle and would like continued clinical surveillance whatever the result.
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PMID:Anticipated reactions to genetic testing for hereditary non-polyposis colorectal cancer susceptibility. 1547 89