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 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Subjective memory complaint is common in later life. Its relationship to future risk of dementia is unclear, although many reports have found a positive association. We designed the present cross-sectional survey to investigate the clinical features associated with subjective memory impairment. One hundred and eight volunteers and 38 non-complainers acting as age-matched controls were recruited. Eleven subjects with memory complaints were excluded because of prior stroke or low MMSE score. The CAMCOG was used to measure cognition; complainers had significantly lower scores (p<0.001). Univariate analysis showed that complainers had greater prevalence of depression, anxiety, insomnia, psychotic phenomenon, difficulties with ADL and word-finding difficulties. The frequency distribution of the apolipoprotein E epsilon4 allele was similar for both groups (p=0.469). Logistic regression analysis indicated that CAMCOG scores (p=0.002) and word-finding difficulty (p=0.002) were independently associated with memory complaints. These results show that memory complainers have worse cognitive performance than non-complainers and support the findings of other studies that suggest that subjective memory loss may be a reliable indicator of cognitive decline.
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PMID:Clinical characteristics of individuals with subjective memory loss in Western Australia: results from a cross-sectional survey. 1124 22

The efficacy of long-term interferon therapy for chronic hepatitis C infection with symptomatic mixed cryoglobulinemia has not clearly been defined. We describe a patient with chronic hepatitis C, symptomatic mixed cryoglobulinemia (cutaneous vasculitis), and membranoproliferative glomerulonephritis (MPGN) who responded clinically, biochemically, and virologically to a 1-year course of interferon therapy. Interferon side effects were minimal. Relapse occurred when interferon was discontinued, and suppressive maintenance interferon therapy was required for clinical, biochemical, and virologic remission. During the 5th year of maintenance therapy, she developed potential side effects that necessitated discontinuation of interferon treatment. After treatment stoppage, a clinical, biochemical, and virologic remission was maintained for more than 1 year. However, the potential side effects, which included eye irritation, arthralgias, myalgias, fatigue, insomnia, memory loss, and depression, persisted. Ophthalmologic, rheumatologic, and neurologic evaluations were nondiagnostic. Psychometric testing revealed dementia and mood disorder. Because the disabling symptoms persisted after 9 months, a health-related quality of life assessment was carried out with the SF-36 survey. Compared with healthy individuals and patients with chronic hepatitis C, our case had a lower health-related quality of life assessment on six out of seven scales and on four out of seven scales of the SF-36 survey, respectively. This case report indicates that long-term maintenance interferon therapy was effective in the treatment of symptomatic mixed cryoglobulinemia and its renal complications and resulted in a clinical, biochemical, and virologic sustained response. It is postulated that the side effects of long-term interferon therapy in this setting may be problematic.
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PMID:The benefit of long-term interferon alfa therapy for symptomatic mixed cryoglobulinemia (cutaneous vasculitis/membranoproliferative glomerulonephritis) associated with chronic hepatitis C infection. 1146 41

This preliminary study addressed some specific attitudes towards menopause, and behavioral styles in menopausal women. The study was conducted during the period January-May 1998 at the Menopausal Service of the Magenta Hospital (Milano) in 88 women, representing almost one half of the patients followed during that period; 43 women were treated with HRT. Some traits characterizing women's life during menopause were examined, such as presence of disturbing physical symptoms, changes in interests and discovery of new interests, and feelings of loss and uselessness. We used different psychological tests in order to evaluate anxiety and depression, in particular, the STAI (State-Trait Anxiety Inventory), the SDS (Self-rating Depression Scale), and 16 cartoon-like images representing stereotypes of menopause. The answers of our subjects showed high individual variation, with negative symptoms (e.g., hot flashes, memory loss) frequently associated with positive experiences (e.g., new hobbies, new life-styles). However, even the most frequent negative symptom (memory loss) was reported only by 70%. The experience of a change represented by menopause was described both in terms of objective change (e.g., weight increase, hot flashes, memory loss), and of subjective change (e.g., character, feeling of not being attractive, new life-styles). Treatment with HRT seems to reduce the onset of hot flashes considerably. The occurrence of anxious-depressive states was comparable to that observed in other studies; it was not associated with HRT, but rather to losses (loss of desire, memory loss, insomnia). In conclusion, menopause represents a transitional moment in which physical and psychological changes are generally integrated by the persons experiencing them. In order to preserve a good quality of life in menopause, it seems relevant to check memory loss and stabilize the mood in persons who are most "at risk" of psychological disease.
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PMID:Attitudes towards menopause in a group of women followed in a public service for menopause counseling. 1169 2

Because use of herbal remedies is increasing, a risk-benefit profile of commonly used herbs is needed. This article provides a clinically oriented overview of the efficacy and safety of ginkgo, St. John's wort, ginseng, echinacea, saw palmetto, and kava. Wherever possible, assessments are based on systematic reviews of randomized clinical trials. Encouraging data support the efficacy of some of these popular herbal medicinal products, and the potential for doing good seems greater than that for doing harm. The published evidence suggests that ginkgo is of questionable use for memory loss and tinnitus but has some effect on dementia and intermittent claudication. St. John's wort is efficacious for mild to moderate depression, but serious concerns exist about its interactions with several conventional drugs. Well-conducted clinical trials do not support the efficacy of ginseng to treat any condition. Echinacea may be helpful in the treatment or prevention of upper respiratory tract infections, but trial data are not fully convincing. Saw palmetto has been shown in short-term trials to be efficacious in reducing the symptoms of benign prostatic hyperplasia. Kava is an efficacious short-term treatment for anxiety. None of these herbal medicines is free of adverse effects. Because the evidence is incomplete, risk-benefit assessments are not completely reliable, and much knowledge is still lacking.
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PMID:The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. 1248 25

Research shows that older adults use memory strategies as a compensatory mechanism for coping with age-related memory loss. This research investigated the type of memory strategies used by older adults living independently in the community in adhering to their prescription medications. Older adults reported greater use of internal memory strategies and a preference for event-based over time-based prescription medication instructions. Depression and memory anxiety were significant predictors of type of medication adherence strategies used among the elderly. Health status and social support were not major determinants of the type of medication adherence strategy used.
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PMID:The role of memory strategies in medication adherence among the elderly. 1198 52

A survey study using questionnaire was conducted in 530 people (270 men, 260 women) living or not in vicinity of cellular phone base stations, on 18 Non Specific Health Symptoms. Comparisons of complaints frequencies (CHI-SQUARE test with Yates correction) in relation with distance from base station and sex, show significant (p < 0.05) increase as compared to people living > 300 m or not exposed to base station, till 300 m for tiredness, 200 m for headache, sleep disturbance, discomfort, etc. 100 m for irritability, depression, loss of memory, dizziness, libido decrease, etc. Women significantly more often than men (p < 0.05) complained of headache, nausea, loss of appetite, sleep disturbance, depression, discomfort and visual perturbations. This first study on symptoms experienced by people living in vicinity of base stations shows that, in view of radioprotection, minimal distance of people from cellular phone base stations should not be < 300 m.
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PMID:[Investigation on the health of people living near mobile telephone relay stations: I/Incidence according to distance and sex]. 1216 54

This study investigated the relationship between measures of frontal lobe functioning (FLF) and verbal memory performance among healthy, community-dwelling older adults (60-85 years old). All were administered measures of FLF, attention, verbal memory, and depression. After controlling for the effects of attention and depression, FLF accounted for significant amounts of the variance in verbal memory scores. Age related to the FLF measure according to the level of organization of verbal material to be recalled. Frontal lobe functioning and performance on an attention measure explained the greatest amount of the variance in the recall of unorganized verbal material, whereas age and attention abilities were the best predictors of the recall of organized verbal material. The data indicate a central role of frontal dysfunction in understanding age-related memory loss.
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PMID:Decline in verbal memory performance with advancing age: the role of frontal lobe functioning. 1221 99

A case is presented of a 38-year old woman who, when treated for alternating amenorrhea and menorrhagia with Lyndiol (.l5 mg mestranol and 5 mg lynestrenol, combined) became anxious and depressed and developed depigmentation and alopecia of her left eyebrow. She showed several symptoms of luteal insufficiency: menstrual disorders, spontaneous abortions, menometrorrhagia, and hyperplastic endometrium, a fter progestagen treatment. During a 6 month course of Lydiol she became severely depressed with short attention span, loss of memory, fatique, frigidity, obsessions and phobic behavior. Treatment with Antideprein (Tofranil) and Napoton (Librium) were not effective, but stopping Lyndiol improved the depression, frigidity, and partially improved the obsessive-phobic behavior. The disscussion centered on the role of monoamines in the depressions associated with oral contraceptives.
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PMID:[Syndrome of depression and depigmentation after administration of combined estrogen-progestagens]. 1225 82

The care of sick and dying persons with AIDS is often provided in the home by family, partners, and friends. This article outlines simple guidelines for such caregivers. Nursing techniques are suggested for common problems such as changing dirty bedclothes with a person in the bed, making a sick person comfortable, eating or swallowing difficulties, pressure sores, mouth care and oral thrush, and loss of memory or personality changes. Health workers can help caregivers to plan how they will manage and share their responsibilities, keep simple medication records, and look after their own health and needs as well as refer them to support groups. Bereavement counseling gives people an opportunity to talk about the events leading up to a death and the death itself, reassure caregivers that any feelings of depression and anger are normal, and enable people to accept the reality of their loss and look to the future.
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PMID:Helping carers to cope. 1229 83

This is a review on current knowledge of chronic occupational mercurialism syndrome. Major scientific studies and reviews on clinical manifestation and physiopathology of mercury poisoning were evaluated. The search was complemented using Medline and Lilacs data. Erethism or neuropsychological syndrome, characterized by irritability, personality change, loss of self-confidence, depression, delirium, insomnia, apathy, loss of memory, headaches, general pain, and tremors, is seen after exposure to metallic mercury. Hypertension, renal disturbances, allergies and immunological conditions are also common. Mercury is found in many different work processes: industries, gold mining, and dentistry. As prevention measures are not often adopted there is an increasing risk of mercury poisoning. The disease has been under diagnosed even though 16 clinical forms of mercury poisoning are described by Brazilian regulations. Clinical diagnosis is important, especially because abnormalities in the central nervous, renal and immunological systems can be detected using current medical technology, helping to develop the knowledge and control measures for mercurialism.
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PMID:[Chronic occupational metallic mercurialism]. 1248 28


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