Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a randomized cross-over design, 7 patients with winter depression were treated with a week of a bright (1700 lx) dawn simulation (0400 to 0600) and a week of standard bright (1700 lx) morning (0600 to 0800) light therapy. The Hamilton Rating Scale for Depression scores decreased significantly for the standard light therapy (18.9 to 6.6) but not for the bright dawn therapy (18.0 to 11.3). Early morning awakening was a frequent side effect with the bright dawn simulation. Although dawn simulation at a lower illuminance may be an effective treatment, the bright dawn used in this study showed only a nonsignificant trend to lower depression ratings. The illuminance of dawn simulation should be adjusted to minimize side effects.
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PMID:Bright dawn simulation compared with bright morning light in the treatment of winter depression. 164 24

Previous studies have suggested that depression might be more strongly related to sleep disturbances in older than in younger individuals. However, few of these studies have simultaneously considered variables other than depression that have been demonstrated to influence the sleep of elderly persons, and none has examined the relationship between depression and sleep longitudinally. The present study examined the association between frequency of depressed mood, using the Depression Adjective Checklist (DACL), and self-reports of four sleep problems over a 3-year period in a sample of community-residing elderly persons. Results showed that frequency of depressed affect was related positively to sleep disturbance, even when subjects' age, gender, and health status were considered simultaneously. Early morning awakening was the sleep symptom that most consistently related to depressed mood over the course of the study. Poor health and female gender showed positive but less consistent relationships to the sleep complaints than depressed affect. Research on biological mechanisms underlying the disturbed sleep of elderly depressed individuals is discussed.
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PMID:A longitudinal study of depressed mood and sleep disturbances in elderly adults. 334 25

The relationship between motor hyperactivity and childhood depression was investigated in a group of 178 children referred for evaluation of school problems. 60% (n = 107) of the children fulfilled the modified Feighner criteria for primary childhood depression. 44% (n = 78) of the children had motor hyperactivity and 75% (n = 59) of these also showed depression. Terminal insomnia, somatic complaints, self-deprecation, episodic loss of interest in school and usual activities, social withdrawal, and preoccupation with death and dying were the symptoms which significantly differentiated depressed from non-depressed children.
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PMID:Non-specificity of motor hyperactivity as a diagnostic criterion. 723 94