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 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The reinforcing properties of amphetamine were assessed in two groups of subjects for whom the drug was hypothesized to be a more effective reinforcer than for control subjects. Preference for amphetamine (5 and 10 mg) over placebo was evaluated in subjects who were concerned about being overweight (n = 13), in subjects with depression (n = 15), and in control subjects (n = 25). Subjective effects of the drugs were measured by self-report questionnaires. All three groups chose 5 mg d-amphetamine as often as they chose placebo. The control and weight-concern group chose 10 mg d-amphetamine significantly more often than placebo. Neither the choice behavior nor the subjective effects of the drug indicated that amphetamine was a more effective positive reinforcer in the experimental groups, because of either its anorectic properties or its presumed antidepressant properties. The results are discussed in terms of the relative risk for stimulant abuse in populations with these characteristics.
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PMID:The reinforcing properties of amphetamine in overweight subjects and subjects with depression. 360 46

The present study investigated daily mood fluctuations and moods during eating in normal and overweight binge and nonbinge eaters (N = 56) and moods during binge and nonbinge episodes of individuals who binge eat (N = 29). For 2 weeks, subjects completed the Multiple Affect Adjective Checklist each morning and continuously recorded the mood during eating and the type and quantity of food eaten during each eating episode. The results indicated that bingers experience greater fluctuations of anxiety and depression than nonbingers and overweight individuals experience greater fluctuations in anxiety, hostility, and depression than normal-weight individuals. In addition, for bingers, negative mood states are experienced during a significantly greater proportion of binge episodes than nonbinge episodes, although the intensity of the negative mood state was not related to the severity of the binge-eating episode. Theoretical and clinical implications of these findings are discussed.
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PMID:Emotional reactivity and eating in binge eating and obesity. 361 85

Sixty-three female patients with anorexia nervosa were assessed for outcome, on average 27.5 months after treatment. The treatment program, in a general adolescent medical service, is multidisciplinary, stressing appropriate weight gain in conjunction with various therapeutic modalities. Half the group required at least one hospitalization; the remainder received treatment as outpatients. Mean weight of the patients was 41.8 kg at first contact, 46.2 kg at conclusion of treatment, and 52.2 kg at follow-up. Average height at the time of follow-up was in the 38th percentile. Average weight was in the 15th percentile at first contact, and in the 29th percentile at follow-up. Current weight is 8% below ideal. Ninety-three percent of the patients had amenorrhea at diagnosis, and 9.5% at follow-up. Vomiting declined from 59% of patients to 16%. Vomiting was significantly associated with poor outcome. The majority function successfully, academically and vocationally. Most continue to restrict diet, and 79% consider themselves overweight. Forty percent report chronic feelings of depression, and 22% have unsatisfactory social relationships. The data suggest no difference in outcome between those receiving psychotherapy (65%) and those who did not (35%). Type and duration of therapy were also not associated with long-range improvement.
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PMID:Follow-up investigation in patients with anorexia nervosa. 399 27

One hundred and eight pregnant women, most of their husbands and a comparison group of non-expectant parents were recruited for a long-term study which involved responding to a 55-item Symptom Checklist (SCL) and the Beck Depression Inventory three times during pregnancy and once during the first postpartum month. Responses to the SCL were factor analysed, and the four groups were then compared on their factor scores as well as their scores on the Beck Depression Inventory (BDI) using discriminant analysis and trend analysis. The discriminant analyses were done twice: once using all the data provided by all subjects and once using only subjects with no missing data. At each measurement period, the pregnant women were distinguished from the other groups by a different factor of the SCL: at 3-5 months, it was 'Feeling Sick'; at 6-8 months, it was 'Feeling Overweight'; at 9 months, it was 'Feeling Overweight/Physical Stress'; and at postpartum, it was 'Physical Stress'. Also, trend analysis showed a significant tendency for the scores of pregnant women on the SCL 'Negative Emotional State', factor and on the BDI to increase over time, in contrast to those of the other groups.
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PMID:A longitudinal study of the reporting of emotional and somatic symptoms during and after pregnancy. 405 47

To evaluate the comparative effects of medical and surgical therapy on quality of life of patients with stable ischemic heart disease, 780 patients who had been randomly assigned to medical or surgical therapy in the CASS were systematically followed for a mean of 5.5. years. Analysis was performed according to original treatment assignment. Patients in the surgical group had significantly less chest pain, fewer activity limitations, and required less therapy with nitrates and beta-blockers. Treadmill exercise tests performed 6, 18, and 60 months after entry documented significantly longer treadmill time, less exercise-induced angina, and less ST segment depression among surgical group patients. However, employment status and recreational status did not differ significantly between medical and surgical groups. Total number of hospitalizations after randomization was higher in the surgical group owing primarily to rehospitalization during the first year of follow-up for the coronary artery bypass graft surgery. Risk factors, including high blood pressure, cigarette smoking, high cholesterol levels, overweight, and poor exercise habits remained similar between medical and surgical groups. This randomized collaborative study shows that coronary artery bypass graft surgery improves the quality of life as manifested by relief of chest pain, improvement in both subjective and objective measurements of functional status, and a diminished requirement for drug therapy. However, no significant effect on employment or recreational status was observed.
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PMID:Coronary artery surgery study (CASS): a randomized trial of coronary artery bypass surgery. Quality of life in patients randomly assigned to treatment groups. 613 93

Responses of 108 women in the first 5 months of pregnancy were compared to those given by expectant fathers, nonpregnant women, and nonexpectant men on two measures: a 55-item symptom checklist and the Beck Depression Inventory. Responses to the symptom checklist were factor analyzed to produce six factors accounting for 40.5% of the total variance. On only two of the six factors was there a significant tendency for the pregnant women to score higher than the other three groups: the factors labeled "Feeling ill" and "Feeling overweight." No significant impact of pregnancy was noted on the Beck Depression Inventory scores. It was concluded that a small group of reported physical symptoms but no common core of emotional symptoms characterizes the experience of early pregnancy.
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PMID:Somatic and emotional aspects of the normal pregnancy experience: the first 5 months. 705 54

The people influence of body weight on the climacteric symptoms of 618 selected women in spontaneous post-menopause has been studied bases on data collected at a Geriatric Centre and subsequently incorporated into a postal questionnaire. These cases were divided into 3 groups according to the "obesity degree": (I) less than 5 kg (53.1% of the cases);(II) between 5 and 15 kg (31.7%); and (III) greater than 15 kg (15.2%). The data were also analysed according to the socio-economic groups to which the women belonged. Overweight women, compared with thin women, seemed to suffer less "somatic" symptoms such as hot flushes and perspiration, independently of their socio-economic level. This might well be a consequence of the higher endogenous oestrogen activity. On the contrary, "psychic" symptoms (anxiety, depression, irritability, crying spells) seemed to be more frequent and severe (a) in the "obesity degree" sub-group III, compared with sub-groups I and II, in the women belonging to the higher socio-economic group, and (b) in the sub-groups I and III, compared with sub-group II, in the women belonging to the lower socio-economic group. Such a difference between the socio-economic groups is possibility due to cultural factors. The effects of endogenous oestrogens in the overweight women seem to be easily overruled by the influence of psychological factors.
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PMID:Climacteric symptoms according to body weight in women of different socio-economic groups. 733 37

A 20-week cognitive stimulus-control treatment program for obesity was conducted in which 27 subjects participated. The program utilized stimulus control procedures, anxiety and depression reduction exercises, and assertiveness training. Statistically significant differences were obtained in weight loss (P < 0.001), anxiety (P < 0.05) and depression (P < 0.01) reduction when comparing pre- and post-treatment scores. Pre-and post-treatmet anxiety (P < 0.05) and pre-and post-treatment depression (P < 0.05) are significantly related. Pre-and post-treatment percent over ideal weight (P < 0.05) is significantly related. A significant relationship exists between years overweight and percentage overweight (P < 0.05); and a significant relationship between pre-treament depression and pounds lost (P < 0.05) is noted. Predictors of success in an obesity-control program are discussed.
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PMID:Cognitive stimulus-control program for obesity with emphasis on anxiety and depression reduction. 741 41

Fifty-three self-defined compulsive eaters recruited from weight loss programs and a college population and prescreened to eliminate probable anorexics and bulimics participated in this study. They completed the Three Factor Eating Questionnaire, Beck Depression Inventory, Compulsive Eating Scale, Eating Obsessive-Compulsive Questionnaire, Personal Assertion Analysis, and provided demographic information. Participants had high scores for compulsive eating and disinhibition and low scores for depression. The best predictors of compulsive eating were disinhibition and obsessive thoughts of food, which accounted for 61% of the variance. Twenty-one percent of the sample reported a history of sexual abuse. Thirty-one percent of the sample were classified as medically obese, yet 49% perceived themselves to be moderately to very overweight.
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PMID:Compulsive eating, obsessive thoughts of food, and their relation to assertiveness and depression in women. 759 68

Although both overweight and body weight fluctuation are related to chronic disease risk, little is known about the history of and reasons for body weight change in the general population. This paper reports the incidence of intentional and unintentional weight loss episodes during adulthood in a population-based sample of 26,261 women aged 55 to 69 years. Intentional weight loss episodes of each of four amounts (5-9, 10-19, 20-49, 50+ lbs.) and unintentional weight loss episodes of 20 or more lbs. were recalled for each of three age periods (18-39, 40-54, 55+ years). At least one intentional weight loss episode of 5 or more lbs. was reported by 69% of women, 46% reported at least one intentional weight loss episode of 10 or more lbs, and 25% reported at least one intentional weight loss episode 20 or more lbs. At least one unintentional weight loss episode of 20 or more lbs. was reported by 29% of the women. Reasons for weight losses of 20 or more lbs. were also recalled. Women who had intentionally lost 20 or more lbs. were more likely to report weight losses due to low-calorie diets, exercise and weight loss groups, while women who had unintentionally lost 20 or more lbs. were more likely to report weight losses due to depression or stress. These findings question the common assumption that weight losses in adult women are primarily intentional and emphasize the need to distinguish the reasons for weight loss in studies examining the relationship between body weight changes and health outcomes.
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PMID:History of intentional and unintentional weight loss in a population-based sample of women aged 55 to 69 years. 771 62


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