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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study examined psychological functioning and satisfaction with weight and figure in a total of 393 obese and nonobese adolescent girls from lower-middle to middle-class families. No significant differences were observed between the two groups on measures of trait anxiety or depression, and all subjects scored well within normal limits. Obese girls did, however, report significantly greater dissatisfaction with their weight and figure than did nonobese girls. Many nonobese girls also expressed dissatisfaction with their weight, supporting the view that women's dissatisfaction with weight is a 'normative discontent'. Nearly 70 percent of the total sample had attempted to lose weight in the past year. The results of this study indicate that obese girls in the general population are dissatisfied with their weight but are not significantly anxious or depressed, as had been suggested by studies of overweight adolescents in clinical settings.
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PMID:Dissatisfaction with weight and figure in obese girls: discontent but not depression. 270 97

Using the Beck depression inventory (BDI), we studied depression in young, healthy, male subjects who represented a wide range of body weight. Body mass index (BMI), defined as the weight (in kilograms) divided by the square of height (in meters), was used to classify subjects as obese (BMI greater than 31.1, n = 27), overweight (BMI = 27.8-31.1, n = 10) or acceptable weight (BMI less than 27.8, n = 26). BDI scores of 0-9 indicated no depression; scores of 10-15 indicated mild depression. BDI scores from 16 to 63 indicated increasing depression. No group of subjects (obese, overweight or acceptable weight subjects), had mean BDI scores suggesting depression. The mean BDI score for the obese subjects was 5.6 +/- 0.8 (mean +/- s.e.m.), which was significantly higher than the mean BDI scores for both the overweight subjects (2.5 +/- 1.1; P less than 0.04) and the acceptable weight subjects (1.5 +/- 0.3; P less than 0.001). There was a weak positive correlation of BDI with BMI (n = 63, r = 0.404, P less than 0.001). In addition, the obese subjects did form a heterogeneous group with four obese subjects (14.8 percent) having BDI score of 10 or greater. The overweight subjects had one subject (10 percent) with a BDI score of 12. None of the acceptable weight subjects had a BDI score of greater than 5. There was no correlation between waist/hip ratios and BDI scores (n = 37, r = 0.262, P = 0.118). We conclude that mild depression is present in some obese persons even when medically healthy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Depression in obese men. 279 1

Tolerability of long term clozapine treatment (7-8 years) was investigated in 27 female patients (age 34-77 years). Diagnosis according to ICD 9 was schizophrenia in 21 patients, severe psychomotor agitation with mental deficiency in 4 patients and an "endogenous" depression in 2 patients. All patients had previously been treated with different neuroleptics but with inadequate response or distressing side effects. The duration of the disorder was 10-36 years, duration of hospitalisation 10-36 years. At the day of investigation the total dose of clozapine ranged from 52-826 g, the average total dose being 385 g. The daily dose of clozapine ranged from 75 to 600 mg, the average daily dose being 225 mg. Only 2 patients were treated exclusively with clozapine, the other 25 patients were also receiving other neuroleptics. Seventy eight per cent of the investigated patients complained about hypersalivation and 63% showed overweight. In 37% of the patients the EEG demonstrated abnormalities. Mild parkinsonism was reported in 15% and akathisia in 11% of the patients, all these patients being on combined treatment. Clozapine did not induce tardive dysakinesia (TD) in any of the patients within a treatment period of 7-8 years. It is concluded that a potential benefit of clozapine includes a low incidence of neurological side effects even after long term administration.
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PMID:Tolerability of long term clozapine treatment. 281 63

We have evaluated the effects of dextrofenfluramine treatment on body weight control during a 90 day period, in obese patients on a calorie-restricted diet. The weight loss in dextrofenfluramine-treated patients was significantly higher than in placebo group. The rate of weight loss was linear up to the end of the trial in d-fenfluramine patients. Neural disturbances (vertigo, headache, depression) were the most frequent side effects observed in both the d-fenfluramine and in the placebo-treated groups, without significant differences between the groups. A total number of 23 patients in the dextrofenfluramine group and 20 patients in the placebo group complained side effects. Six patients (five in the d-fenfluramine group and one in the placebo group) discontinued the treatment, due to the side effects. No modifications of the biochemical parameters considered (fasting blood glucose, bilirubin, alkaline phosphatase, creatinine, blood cell counts, asparate-amino transferase (AST), alanine-amino transferase (ALT), total plasma and HDL cholesterol, and triglycerides) were observed at the end of the trial. A significant reduction of total serum cholesterol was observed in both groups at the end of the period of treatment. In conclusion, dextrafenfluramine was proved to be in short term trials an effective and safe tool in overweight control in obese patients.
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PMID:Efficacy and safety of dexfenfluramine in obese patients: a multicenter study. 305 15

One thousand and ten unselected London state schoolgirls were screened by questionnaire to identify an 'at risk' cohort displaying abnormal eating attitudes and two control cohorts, one with probable general psychiatric morbidity, one without. Members of all cohorts were assessed at interview for the presence of eating disorder and for putative risk factors implicated in the development of anorexia nervosa. A prevalence rate of 0.99% was detected for clinical eating disorder and 1.78% for the partial syndrome of eating disorder. Factors specifically associated with abnormal eating attitudes were identified, in particular, current or past overweight, history of amenorrhoea and perceived stress in school and social life. Some commonly accepted risk factors for eating disorders were discovered to be associations with general psychiatric morbidity. These were perceived parental pressure to eat more, taking exercise to lose weight, perceived stress at home and reporting a family history of anxiety or depression. Other well reported putative risk factors for eating disorder, including social class, birth order, age at menarche, obsessional personality and weight related career choice were not associated specifically with abnormal eating attitudes in schoolgirls. These findings represent cross-sectional data at entry into a prospective epidemiological study.
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PMID:Abnormal eating attitudes in London schoolgirls--a prospective epidemiological study: factors associated with abnormal response on screening questionnaires. 318 65

In a representative sample of 401 adults in Illinois in 1984, the authors found that increased participation in exercise, sports, and physical activities is associated with improved psychologic well-being. Part of this association is through improved subjective physical health. The authors controlled for potentially confounding factors, including sociodemographic characteristics, instrumentalism, and overweight. They concluded that exercise is associated with decreased symptoms of depression (feelings that life is not worthwhile, low spirits, etc.), anxiety (restlessness, tension, etc.), and malaise (rundown feeling, trouble sleeping, etc.) in the general population, most of which is not severely depressed, and in which many persons are engaged in moderate, nonaerobic exercise.
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PMID:Exercise and psychologic well-being in the community. 325 71

Serum iron, folate, B12 and total iron binding capacity (TIBC) were obtained preoperatively and at 6-month intervals in 40 morbidly obese patients who underwent VGB. Deficiencies of hemic micronutrients rarely occurred following VBG. Hemoglobin and hematocrit levels were within normal limits at all times. Some patients experienced transitory depression of nutrients at six months postoperatively, during the period of most rapid weight loss and lowest dietary intake. These levels return to normal by one year in almost all cases. Low B12 levels were observed in four patients at 1 year. All had been above 120 per cent overweight and had lost in excess of 100 pounds in the first postoperative year. These data indicate that hemic micronutrients remain at normal levels following VBG. B12 levels should be followed to determine possible need for supplementation other than that provided by usual daily multivitamin preparations in patients above 120 per cent ideal weight loss exceeding 100 lbs in the first postoperative year.
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PMID:Hemic micronutrients following vertical banded gastroplasty. 336 61

A health needs assessment was developed to facilitate implementation of a comprehensive school-based adolescent clinic. Students were asked about their willingness to use a school-based clinic for certain health and emotional problems. 600 students in grades 9-12 completed anonymous self-administered questionnaires. 28% of respondents reported recently feeling depressed; 12% reported a prior suicide attempt. 25% of students felt they were overweight. Of 56% who had experienced intercourse at least once, only 1/3 had ever used birth control. 21% smoked cigarettes and 27% marijuana, 24% used other drugs, and 38% used alcohol. Students who reported depression and past suicide attempts were significantly (p 0.001) more willing to use the clinic for counseling needs than students not so reporting. Those with perceived weight problems reported more willingness to use a school clinic for nutrition information than those who did not feel overweight. Currently sexually active students were also more willing (p 0.001) than nonsexually active students to use the clinic for sexuality information and sexually transmitted disease screens. Respondents who used drugs, alcohol, or cigarettes, however, were no more willing than non-substance-using peers to use clinic services for relevant health information. As a group, adolescents have some unique age-related health problems. Because adolescence represents a time when health behaviors and attitudes are being formed, it is a crucial time for health intervention. These findings suggest that high school students with unmet health needs are willing to receive health care and education at a school-based clinic.
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PMID:Adolescents' willingness to use a school-based clinic in view of expressed health concerns. 337 87

This study shows fluoxetine to be a potent anorectic agent in non-depressed clinically overweight individuals. It is as effective an anorexic compound as a currently available appetite control agent, benzphetamine, and highly significantly more effective than the placebo treatment. A relative lack of serious side-effects and a low abuse potential make it an interesting drug in the slim armamentarium of agents that are used to treat the overweight. If the lack of tolerance to the effects of this drug seen in the long-term studies of depression is confirmed in long-term studies of obese patients, fluoxetine may have a major part to play in the treatment of the obese patient where weight loss is medically indicated. This would include the morbidly obese, the type II diabetic, and the hypertensive patient. Although ideally behavior modification should accompany the drug treatment for obesity, clinical practice indicates that in many cases, patients will not follow through with the behavioral treatment. A strictly medical prescription of an acceptable pharmacologic agent like fluoxetine on a chronic or long-term basis may provide a new possibility for the treatment of these individuals.
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PMID:Fluoxetine-induced weight loss in overweight non-depressed humans. 350 92

Bulimia is characterized by recurrent episodes of binge eating and severe self-deprecation, often accompanied by self-induced vomiting and/or laxative abuse. It is most often found among young women in their late teens to mid-30s. Estimates of the disorder's prevalence vary widely, depending on the diagnostic criteria used, but usually range from 5% to 20% of college age women. Binge eating typically begins in late adolescence, frequently after a period of dieting to lose weight. Self-induced vomiting usually follows the onset of binge eating by about a year. To date, theories of the disorder's etiology have included several biological models, a psychosocial model, and a biopsychosocial model. The biological models proposed have viewed bulimia as a form of biological depression, neurological disturbance, or metabolic disturbance. The psychosocial model suggests that society's pressure on young women for extreme thinness leads to excessive dietary restraint, deprivation, and, paradoxically, binge eating. The presence of anxiety or depression exacerbates the process. The biopsychosocial model appears to be the most promising. It proposes that young women with biological predispositions toward overweight, depression, or metabolic disturbance are particularly vulnerable to social pressure for thinness, the binge eating that may result from excessive dieting, and, hence, bulimia. The complex nature of bulimia suggests that a multidisciplinary team approach treatment is appropriate.
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PMID:Bulimia: clinical characteristics, development, and etiology. 351 31


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