Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From 1980 to 1984, a total of 2,329 people who alleged that they had been bitten by venomous snakes were admitted to 292 Italian hospitals having first aid stations. Three died. Most patients (62%) did not show any symptomatology of envenomation. The epidemiological and clinical aspects of 286 patients, out of 885 exhibiting signs and symptoms of snake bite envenomation, have been studied. The symptoms and signs were: oedema, gastro-intestinal symptoms, pain at the site of the bite, respiratory distress, leucocytosis, CNS depression, shock, fever, cyanosis, exanthema, ecchymoses, incoagulable blood, lymphangitis, melaena, thrombocytopenia, haematuria, and ophthalmoplegia. The bites were located only in the upper or lower limbs. Most were caused by Vipera aspis. The severity of envenomation of the 286 affected patients were: 45% minor, 30% mild, 14% moderate, 8% severe and 1% fatal. Most bites occurred in August. The commonest treatment before and during hospitalization was anti-venin.
 ...
PMID:Venomous snake bites in Italy: epidemiological and clinical aspects. 338 30

Antiarrhythmic-induced hypoglycemia is an ill-defined phenomenon. Sporadic cases have been reported with disopyramide, a class IA antiarrhythmic agent. We report a case of cibenzoline-induced hypoglycemia in an elderly male with a history of ischemic heart disease, congestive heart failure, ventricular arrhythmias, and chronic obstructive pulmonary disease. Cibenzoline is a class I antiarrhythmic agent currently undergoing clinical investigation in the U.S. The initial hypoglycemic episode occurred after two years of successful treatment with cibenzoline. Blood glucose during the first hypoglycemic episode was 40 mg/dL. The hypoglycemia was associated with central nervous system depression, hyperkalemia, electrocardiographic abnormalities, and respiratory distress. Rechallenge with cibenzoline resulted in recurrence of symptoms and a blood glucose level of 21 mg/dL. A second rechallenge resulted in symptoms suggestive of hypoglycemia, but cibenzoline was discontinued before frank hypoglycemia and hyperkalemia recurred. Hypoglycemia occurred during periods of fasting, which most likely ruled out reactive-type hypoglycemia. Insulinoma was ruled out by the presence of normal fasting blood glucose and plasma insulin levels. It was concluded that this patient's hypoglycemia was secondary to cibenzoline. Hypoglycemia is a rare and sporadic adverse effect associated with antiarrhythmic therapy. However, the severity of these reactions warrants increased awareness of their occurrence in patients presenting with symptoms of hypoglycemia who are receiving disopyramide or cibenzoline.
 ...
PMID:Cibenzoline-induced hypoglycemia. 354 36

The well-known increased risk of the respiratory distress syndrome in a twin born second as compared with the twin born first is usually attributed to the second twin's predisposition to depression at birth ("asphyxia"). We analyzed the etiologic roles of birth order, presentation, and depression at birth in the development of the respiratory distress syndrome in matched case-control populations drawn from 221 preterm twin pairs. Among the 39 twin pairs discordant for respiratory distress syndrome, the second twin was the affected member in 31 pairs. Second birth order was the only independent risk factor, but only in vaginal deliveries (matched odds ratio, 14.2; 95 percent confidence interval, 2.5 to 81.1). Second twins delivered abdominally did not have an increased risk relative to first twins (odds ratio, 0.9; confidence interval, 0 to 17.8). When depression at birth was evaluated as an outcome variable, malpresentation, rather than birth order, was the major risk factor (independent matched odds ratios of 2.7 [confidence interval, 1.0 to 7.5] and 1.3 [0.7 to 2.5], respectively). Thus, second twins' increased risk of respiratory distress syndrome cannot be explained by a predisposition to depression at birth; a more important factor may be that second twins do not benefit from the salutary effects of labor to the same extent as first twins.
 ...
PMID:Respiratory distress syndrome in second-born versus first-born twins. A matched case-control analysis. 365 79

The relationship between fetal head compression and the occurrence of intraventricular hemorrhage was examined in 101 very-low-birth-weight (500 to 1500 g) vertex neonates. Peripartum events related to head compression, including parity, rupture of membranes, labor, episiotomy, use of forceps, and cesarean birth were not significantly related to intraventricular hemorrhage. A birth weight of less than 1250 g, neonatal depression (one minute Apgar score less than 7), respiratory distress syndrome, and neonatal mortality were significantly associated with intraventricular hemorrhage (P less than .05). These findings suggest that head compression in the vertex very-low-birth-weight fetus, as encountered in current obstetric practice, is not a major determinant of intraventricular hemorrhage. When premature delivery is inevitable, focusing on efforts to avoid a depressed one-minute Apgar score appears to be a more promising approach for the prevention of intraventricular hemorrhage than routinely using cesarean birth.
 ...
PMID:Reconsideration of head compression and intraventricular hemorrhage in the vertex very-low-birth-weight fetus. 372 56

Clinical and pulmonary function changes induced by intravenous dichlorvos (2,2-dichlorvinyldimethyl phosphate) (DDVP) toxicosis, and reversibility of these changes after atropine treatment were investigated in six Friesian calves one to three months old. From one minute after dosage, all animals showed severe respiratory distress, excitation, weakness, muscle fasciculation and cholinesterase inhibition. Decrease in dynamic lung compliance and arterial oxygen tension and increase in total pulmonary resistance, viscous work of breathing and alveolar arterial oxygen gradient were highly significant (P less than 0.01). On the other hand, body secretions, heart rate, respiratory rate, tidal volume and arterial carbon dioxide tension were not significantly affected by DDVP injection. Atropine promptly and completely reversed these changes, except for muscle fasciculations, central depression and cholinesterase inhibition which disappeared progressively within 24 hours.
 ...
PMID:Pulmonary function changes induced by experimental dichlorvos toxicosis in calves. 373 27

Few studies have been published about analgesic management practices during sickle cell pain crisis. Therefore, we reviewed the records of all hospitalized children with this complication during a recent five-year period. The 38 patients (98 painful episodes) who received intravenous narcotic therapy were the subjects of this review. In 76 patients, an initial intravenous bolus injection of morphine sulfate or meperidine hydrochloride was followed by a continuous intravenous infusion of one of these two drugs. To achieve adequate pain control, adjustments in infusion rates were made according to a written protocol. In 22 other patients, subsequent narcotic treatment consisted only of intermittent intravenous bolus injections of meperidine. Satisfactory pain relief was achieved in all 98 episodes. Patients given continuous infusions required more narcotic to control their pain and had more side effects than those treated with bolus injections alone, suggesting a dose-response relationship between narcotic dose and several known side effects. Common side effects included nausea and vomiting, lethargy, and abdominal distention. Although clinically evident respiratory depression was quite uncommon, chest syndrome was a frequent complication, and severe respiratory distress occurred in three patients. Narcotic withdrawal or addiction was not observed. With careful monitoring (including special attention directed to avoiding dosing error), continuous intravenous narcotic infusions are safe and provide effective pain relief for severe sickle cell pain crisis.
 ...
PMID:Intravenous narcotic therapy for children with severe sickle cell pain crisis. 377 42

Since the introduction of ophthalmic timolol solution in 1978 there have been numerous reports of systemic toxicity associated with its use. The majority of the systemic side effects reported are the same as those associated with oral timolol. Several cases of respiratory distress have been described generally in patients with underlying restrictive airway disease. Cardiovascular effects range from effects on resting pulse rate to the development of overt bradycardia and heart failure. Central nervous system effects reported include fatigue, confusion, depression, and hallucinations. A variety of other systemic effects have also been described. Caution should be used when ophthalmic timolol is administered to elderly patients or those patients with contraindications to systemic beta-blockers.
 ...
PMID:Systemic side effects associated with the ophthalmic administration of timolol. 388 77

The outcome of two populations of twins delivered at the same hospital, numbering 554 in 1963 to 1972 and 614 in 1978 to 1984, was reviewed to determine the factors contributing to depression at birth, trauma, and mortality in each period. The cesarean section rate had increased from 3% in the early period to 51% in the later period, with 92% of the later cases in which the first twin presented abnormally being delivered by cesarean section. Among infants of greater than 28 weeks' gestation the incidence of severe depression at birth was not reduced with the increased cesarean rate, remaining at 2% in both populations; none developed encephalopathy or died as a result of birth asphyxia or trauma. Neonatal mortality was markedly reduced in the second period, primarily because of a reduction in deaths resulting from respiratory distress syndrome. It is not possible to show that the marked increase in the rate of cesarean delivery has improved the condition of twin infants at birth.
 ...
PMID:Birth asphyxia, trauma, and mortality in twins: has cesarean section improved outcome? 394 9

The acute effects of diisopropylfluorophosphate (DFP) were assessed in DBA/2Ibg, C57BL/6Ibg and C3H/2Ibg mice. The DFP was administered by intraperitoneal injection in saline. Brain acetylcholinesterase (AChE) activity was maximally inhibited within 5 min after injection. All mice showed signs of organophosphate intoxication including salivation, lacrimation, diarrhea, respiratory distress, tremor and, at high doses, seizures. The C57BL mice were most susceptible to these effects of DFP. The LD50 values for DFP were 8.0, 7.6, and 6.8 mg/kg for male DBA, C3H, and C57BL mice, respectively. The LD50 values for females were nearly the same. Body temperature and brain AChE activity decreased in a dose-dependent manner following injections of DFP of 3.17, 4.22, 5.28, and 6.33 mg/kg. Maximum temperature depression occurred 2 hours after DFP administration; by 24 hours temperatures had returned to normal except for C57BL mice treated with the highest dose of DFP. The C57BL strain was most susceptible to the DFP-induced hypothermia, the C3H strain was the most resistant, and the DBA strain was intermediate. Maximum temperature depression and residual AChE activity, as measured 24 hours after injection, were linearly related. These strain differences do not seem to be explained easily by a differential inhibition of AChE activity.
 ...
PMID:Genetically determined differences in acute responses to diisopropylfluorophosphate. 399 71

From April to August, 1981, 15 cases of perinatal listeriosis were seen in Halifax, Nova Scotia, Canada. Nine of the 15 mothers presented with 'flu-like' symptoms, 3 had symptoms of an upper respiratory infection and 2 a history of fever alone. During labor 11 mothers had fevers greater than 38 degrees C and 9 had stained amniotic fluid. Twelve delivered prematurely. Among the 15 infants the most common clinical features were perinatal depression, respiratory distress, fever, hematologic abnormalities and rash. There were 7 deaths (case fatality rate of 46.7%). A transplacental route of infection for the fetus was suggested by the signs of systemic illness in most mothers, the lack of positive maternal vaginal cultures and evidence of chorioamnionitis, premature labor, severe fetal disease and intrauterine death prior to membrane rupture. The delivery of healthy infants to two mothers who had received antepartum treatment for listeriosis suggests that earlier recognition and treatment of maternal disease will improve perinatal outcome.
 ...
PMID:Perinatal listeriosis: report of an outbreak. 400 Sep 86


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>