Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical signs of generalized granulomatous disease in a horse included depression, generalized lymphadenopathy, scaly skin, and dependent edema. Diagnosis was confirmed histopathologically by diffuse granulomas in more than one organ system (lymph nodes and skin), and by ruling out etiologic agents. Response to treatment with corticosteroids was favorable. The clinical features and response to treatment in this horse were different from classic textbook descriptions of equine generalized granulomatous disease. Equine granulomatous disease appears to be comparable to human sarcoidosis. To avoid confusion between human medical and veterinary medical terminology, the authors suggest that the equine disease be referred to as equine idiopathic granulomatous disease and that a complete diagnostic description should include a reference to the organ systems involved.
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PMID:Idiopathic granulomatous disease involving the skin in a horse. 224 35

Zinc deficiency was produced experimentally in guinea-pigs fed on a diet containing 1.03 mg Zn/kg over a period of 45 days. Clinical signs exhibited in Zn-deficient (ZnD) animals were depression with abnormal posture, scaly skin lesions on various parts of the body, oedematous swelling on hind limbs and marked alopecia. There was no effect on food intake. Serum studies in ZnD group revealed significant decreases in the concentrations of Zn from 20 days onwards, and tri-iodo-thyronine (T3) and thyroxine (T4) from 30 days onwards. Thyroid glands of ZnD animals were smaller in size and pale or whitish pale in colour. Histopathologically, these glands showed changes of atrophy and degeneration in the follicles. It could be concluded that the depletion in serum T3 and T4 due to Zn deficiency was related to thyroid lesions.
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PMID:Effect of experimental zinc deficiency on thyroid gland in guinea-pigs. 949 Nov 94

Psoriasis is a chronic inflammatory skin condition that is often associated with systemic manifestations. It affects about 2 percent of U.S. adults, and can significantly impact quality of life. The etiology includes genetic and environmental factors. Diagnosis is based on the typical erythematous, scaly skin lesions, often with additional manifestations in the nails and joints. Plaque psoriasis is the most common form. Atypical forms include guttate, pustular, erythrodermic, and inverse psoriasis. Psoriasis is associated with several comorbidities, including cardiovascular disease, lymphoma, and depression. Topical therapies such as corticosteroids, vitamin D analogs, and tazarotene are useful for treating mild to moderate psoriasis. More severe psoriasis may be treated with phototherapy, or may require systemic therapy. Biologic therapies, including tumor necrosis factor inhibitors, can be effective for severe psoriasis and psoriatic arthritis, but have significant adverse effect profiles and require regular monitoring. Management of psoriasis must be individualized and may involve combinations of different medications and phototherapy.
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PMID:Psoriasis. 2366 31