Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since beginning of his illness the patient suffering from cancer no longer feels like active participant, but passive onlooker towards social life. He has to fight against intensive feelings of loss (e.g. loss of health, of organs, of abilities...); cancer always means leave-taking, grief and bereavement. Patients in hospitals have to suffer mainly from: decline of activities, decrease of subjectively perceived physical status, labile selfesteem, depression and exhaustion. It is pointed out that knowledge of one's self means an inalterable assumption for every person working with cancer patients.
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PMID:[Psychological problems and management of cancer patients from the viewpoint of the clinical psychologist]. 269 25

Within transcultural psychiatry there is a continuing debate between universalist and relativist positions. This debate focuses on the translation of Western psychiatric categories to non-Western languages and cultural contexts, and on the cross-cultural applicability of a Western model of human nature. This debate is of concern to medical practitioners and other primary carers who work with ethnic minority patients. The paper describes a syndrome of heart distress referred to as "sinking heart' by Punjabis living in Bedford, and it discusses how far this condition correlates with Western psychiatric categories. "Sinking heart' is an illness in which physical sensations in the heart or in the chest are experienced and these symptoms are thought to be caused by excessive heat, exhaustion, worry and/or social failure. The Punjabi model of "sinking heart' offers a culture-bound explanation of somatic symptoms. It is based on culturally specific ideas about the person, the self and the heart and on the assumption that physical, emotional and social symptoms of pathology accompany each other. This model is compared with Western notions of depression and with medical models of heart distress, type A behaviour pattern and stress. The paper concludes that the Punjabi model of sinking heart does not exactly correspond to any of these. The sinking heart model bears closest resemblance to a Western model of stress. The similarity between these two models is in the form rather than in the content.
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PMID:Sinking heart: a Punjabi communication of distress. 275 40

The activity of oxygen-dependent metabolism (OM) was investigated in phagocytosing cells from a primary focus in plague infection using a mouse model. Experimental animals were given various i.p. doses of a virulent culture of Y. pestis. Changes in the OM of neutrophils and macrophages derived from peritoneal exudate after Y. pestis administration were phased and identical to non-specific post-aggression fluctuating reaction (PFR) comprising: 1. immediate depression phase, 2. overexertion phase and 3. exhaustion phase.
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PMID:Changes in the activity of oxygen-dependent metabolism in polymorphonuclear leukocytes and macrophages from a primary focus during experimental Y. pestis infection in the mouse. 276 22

This study examined the effect of designated interventions in nursing practice problems on levels of burnout in nurses. A battery of tests measuring burnout, self-esteem, depression, personal accomplishment, depersonalization, and emotional exhaustion were given to nurses in experimental and control groups. Pre- and post-test data were gathered for both groups. The treatment included a 2-day conference which was designed as a respite experience to address problems specific to the nursing profession. Results indicate significantly less burnout, less frequency of depersonalization, and significantly greater frequency of personal accomplishment in the scores of the experimental group relative to the control group. This study shows that specific interventions can be used to benefit the emotional well-being of nurses by providing them with a respite opportunity and the skills to manage key stressors in their professional environment.
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PMID:Interventions for nursing practice problems. 276 13

We evaluated 74 peripheral vascular disease (PVD) patients (54 men, age 61 +/- 7 years and 17 women, age 63 +/- 7 years) for potential coronary heart disease (CAD) using an arm exercise test (AET) protocol. All patients performed upright two-arm cranking using discontinuous stages of 2 minutes of exercise separated by 2 minutes of rest. Exercise intensity was increased by +100 or 200 kpm (kilopond meters) with each stage. ECG was monitored continuously and blood pressure and 12-lead ECG tracings were obtained at the end of each exercise stage. All patients reached an endpoint of subjective exhaustion. Men achieved 91 +/- 14% of age-predicted heart rate at 597 +/- 167 kpm, while women achieved 86 +/- 14% of age-predicted heart rate at 335 +/- 117 kpm. Ischemic ECG responses (+AET) defined as new or additional ST depression greater than 1.0 mm X 80 ms, occurred in 35 men (65%) and 7 women (42%). Coronary angiography was performed in a subset of 22 patients (15 males and 7 females). CAD (greater than 70% stenosis) was found in 11 of 12 men and 4 of 5 women who showed positive or strongly positive AET responses (overall predictive value for AET = 88%). We conclude that arm exercise stress testing is safely performed in PVD patients who cannot complete treadmill exercise. In this limited series of PVD patients, the predictive value of a +AET response for diagnosis of CAD is similar to established values for treadmill exercise.
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PMID:Arm exercise testing for coronary artery disease in patients with peripheral vascular disease. 289 61

The General Health Questionnaire (Goldberg and Hiller, 1978, 1979) is a screening instrument for clinical and preclinical assessment of psychosomatic disorders and proneness to such disturbance. It has been translated into German by F. Gutzwiller for a national health survey (SNF 8/SOMIPOPS) and has been used thereafter in several studies in combination with other psychometric instruments. This current paper presents a set of test-related theoretical and statistical parameters of the GHQ (28-item version). The specificity of the proposed scales (somatic symptoms, anxiety and insomnia, social dysfunction, severe depression) is relatively low in the German version. Nevertheless may the questionnaire be recommended for nonclinical and nonpsychiatric in-patient use, as it picks up aspects of depression and suicidal behavior, of a general disturbance feeling, and of mental and psychophysical stress and exhaustion. Further evaluation is recommended.
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PMID:[A report on experiences using Goldberg's GHQ (General Health Questionnaire)]. 292 19

The responses of muscle spindles in the iliofibularis muscle of the cane toad Bufo marinus were examined during constant velocity stretch of the passive muscle. Spindles were found to show an 'initial burst' of high frequency impulses at the onset of stretch. Associated with the initial burst was a steep passive tension rise in the whole muscle, the short-range elastic component (Hill, 1968), called here the passive stiffness. The size of the initial burst was found to depend on muscle length in a similar way as whole-muscle tetanic tension. Repetitive stretch was found to reduce both the initial burst and passive stiffness. The time taken for both to return to their control values was 3 and 10 s respectively. If immediately following repetitive stretch the muscle, and hence the spindle, was held stretched for 3 s, the initial burst in response to a subsequent stretch from a shorter length remained reduced in size for 300 s. The depression could be reversed by a brief period of fusimotor stimulation. Hypertonic Ringer solutions were found to increase the initial burst and passive stiffness, while both were reduced in hypotonic solutions. Low concentrations of caffeine (1.5 mM) produced a similar decrease in both the initial burst and the passive stiffness. Calcium-free Ringer solution left the stiffness unchanged, and increased the whole dynamic response of the spindle. Metabolic exhaustion and poisoning of the muscle caused the initial burst to increase while decreasing the active tension. It is concluded that the initial burst is an intrafusal manifestation of the passive short-range stiffness of extrafusal muscle which is thought to be due to the formation of stable cross-bridges between the actin and myosin filaments of myofibrils.
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PMID:The initial burst of impulses in responses of toad muscle spindles during stretch. 293 46

Spleen cells from CBA/J mice infected with Neisseria meningitidis displayed depressed in vitro plaque-forming cell (PFC) responses to T-dependent (sheep red blood cell; SRBC) and T-independent (TNP-LPS, TNP-Ficoll) antigens. The inhibition was observed over a wide range of antigen concentrations. The decreased responsiveness of splenocytes from infected mice was due to a selective impairment of B-cell function since helper-T-cell activity was intact in infected mice as shown by the ability of T-enriched lymphocytes to cooperate with normal B-enriched lymphocytes in the generation of an anti-SRBC response, accessory macrophage function was preserved since adherent spleen cells from bacteria-injected mice were shown to produce normal or increased levels of IL-1 and were able to cooperate with normal non-adherent spleen cells in the generation of PFC against SRBC. Addition of peritoneal cells from normal animals or extraneous IL-1 both failed to restore normal PFC responses in cultures of splenocytes from infected mice. Finally, B-enriched lymphocytes from infected mice produced poor anti-SRBC responses when cultured with either Con A supernatant or T-enriched lymphocytes from normal or infected mice. Cell-mixing experiments failed to detect the presence of suppressor cells in cultures of unfractionated spleen cells or B-enriched lymphocytes from infected mice. Therefore, the immunological unresponsiveness associated with a Neisseria meningitidis infection was attributed to a meningococcus-induced defect(s) in B-cell function. In vivo polyclonal B-cell activation leading to clonal exhaustion did not play a major role in the depression of humoral responses since meningococcal infection induced little or no polyclonal Ig secretion.
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PMID:Selective impairment of B cell function by Neisseria meningitidis. 294 9

The effect of iron deficiency on work capacity was studied in groups of rats that had received diets with iron contents ranging between 9 and 50 mg/kg diet from 3 to 6 wk of age. Maximal O2 consumption (VO2max) declined only 16% with a decrease in hemoglobin (Hb) from 14 to 8 g/dl and fell sharply only below a Hb of 7 g/dl. Duration until exhaustion in a treadmill exercise of submaximal intensity (endurance) showed no significant depression between a Hb of 14 and 10 g/dl. However, endurance declined abruptly by 73% between a Hb of 10 and 8 g/dl. The VO2max results are in accord with known compensatory mechanisms that help to maintain delivery of O2 to tissues until anemia becomes severe. The sharp fall in endurance with relatively mild iron deficiency suggests a lack of similarly effective compensations for decreased oxidative capacity of muscle.
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PMID:Work performance in iron deficiency of increasing severity. 298 75

Myalgic Encephalomyelitis or post-viral fatigue syndrome is a common disorder, which has been known previously under a variety of different names, i.e., Iceland disease or Royal Free disease. It may occur in epidemics or sporadically. The cause is unknown, with patients complaining of exhaustion, fatigue, muscle aches and pains, and invariable psychiatric symptoms such as emotional lability, poor memory/concentration, and depression. Present-day research points to the cause as a metabolic disorder secondary to persistent viral infection.
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PMID:Postviral fatigue syndrome. 306 94


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