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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A deficiency of dietary zinc during the suckling period of the rat results in a depression in normal growth, which is, in part, due to the inanition experienced by the dam. The pups from such zinc-deficient dams have smaller forebrains at all of the time intervals investigated in comparison with pups from both zinc-adequate controls. The cell number of the forebrain of the zinc-deficient pup was also reduced in comparison with the zinc-adequate pups. RNA concentration did not appear to be affected, although the total RNA content was reduced because of the smaller brain size. The amount of protein per cell was reduced at 6 and 15 days in the zinc-deficient forebrain and polysomal profiles displayed abnormal distribution of material between monosomes and polysomes in the zinc-deficient brain. Zinc deficiency during the suckling period thus appears to disadvantage the animal in terms of body, brain growth, accretion of cells into the forebrain, and normal protein metabolism.
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PMID:Some effects of postnatal zinc deficiency on developing rat brain. 111 96

The purpose of these studies was to evaluate the short-term toxicity of theophylline, a compound present in tea and used in a variety of clinical applications. Fourteen-day repeated-dose toxicity studies were conducted in B6C3F1 mice and F344 rats of both sexes. Theophylline was administered in feed (0, 500, 1000, 2000, 4000, and 8000 ppm) or by gavage in corn oil (12.5-twice daily, 25, 50, 50-twice daily, 100, 200, 200-twice daily, and 400 mg/kg). Dosed-feed exposure to theophylline at concentrations up to 8000 ppm induced no significant toxicity except for dose-related uterine hypoplasia in rats. Palatability problems at that level precluded administration of higher concentrations. In the gavage study, 400 mg/kg was acutely toxic for both species, but mice and rats differed in that this same daily dose administered as two separate doses of 200 mg/kg was acutely toxic in rats but not in mice. No dose-related weight gain depression was evident in mice; weight gain was depressed in the majority of dose levels in rats and was pronounced at the higher levels. Clinical signs in mice were squinting and distended testes in males, and in rats, rapid respiration (all doses), squinting, and hunching. Gross necropsies, organ weights, clinical pathology, and pathology identified no target organs in mice, while histopathologic observations in rats suggested heart and stomach as possible target organs. Histopathologic effects in a number of other tissues, including lung, thymus, bone marrow, spleen, and uterus, were considered to reflect agonal changes in treated rats, possibly related to inanition. The results suggest that both species and sex differences exist with respect to sensitivity to theophylline toxicity, with F344 rats being more sensitive than B6C3F1 mice and male rats being more sensitive than female rats.
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PMID:Studies on the short-term toxicity of theophylline in rats and mice. 337 86

Gastric hairballs in a colony of mature laboratory rabbits were associated with chronic, partial, or complete gastric obstruction and inanition. Clinical signs included anorexia, decreased fecal output, weight loss, and depression. The differentiation of anorexia induced by hairballs, stress, and other causes presented a diagnostic dilemma. Radiographs could not be relied upon to differentiate gastric hairballs from normal gastric contents. Combined medical and surgical management optimized successful recovery. Supportive therapy was given 12 to 24 hours before surgical removal of the hairball and was continued postoperatively for 72 hours.
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PMID:Medical and surgical management of gastric obstruction from a hairball in the rabbit. 664 29

1. Oxygen consumption was measured by means of an O2 electrode in mitochondrial suspensions from riboflavin-deficient and pair-fed control rats, using six different substrates. Whereas consumption of O2 by glutamate was only slightly depressed in mitochondria from deficient animals, the consumption of O2 by hexanoate and by palmitoyl-L-carnitine was depressed to approximately half the control value: a highly significant difference. A comparable magnitude of depression was observed for stearoyl-, oleoyl-, and linoleoyl-L-carnitine. There were no major or consistent differences between groups of animals receiving two different types, and two different levels, of fat in their diet. 2. The activity of acyl coenzyme A dehydrogenase (EC 1.3.99.3) in hepatic mitochondrial fragments, measured by cytochrome c reduction with palmitoyl-coenzyme A as substrate, and expressed as maximum velocity (Vmax) with respect to phenazine methosulphate, was also reduced to approximately half the control value in deficient animals. 3. In hepatic microsomes, cytochrome b5 reductase (EC 1.6.2.2) activity was unaffected by riboflavin deficiency, although NADPH-cytochrome c reductase (EC 1.6.2.4) and microsomal flavin content were diminished to approximately half the control values. Acyl CoA (delta 9) desaturase activity (EC 1.14.99.5) was virtually identical in deficient, pair-fed, and ad lib.-fed control groups. 4. It is concluded that the depression of mitochondrial beta-oxidation of fatty acids which is observed in riboflavin-deficient animals is not a secondary result of inanition, and may account for the observed changes in fatty acid profiles of triglycerides and phospholipids. Failure of the microsomal fatty acid desaturation system is less likely to be a major consequence of riboflavin deficiency.
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PMID:Lipid metabolism in riboflavin-deficient rats. 2. Mitochondrial fatty acid oxidation and the microsomal desaturation pathway. 708 27

The importance of depression as a psychopathologic syndrome in the elderly is stressed by the estimate that about 30 percent of persons over the age of 65 may be expected to experience an episode of depression severe enough to interfere with daily functioning. Depression is the chief cause of psychiatric hospitalization among the elderly, and it bears great potential for death through inanition or suicide. Loss of mastery (ability to cope) and the onset of helplessness are frequent dynamic issues in the development of depression or behavioral problems in the elderly. Geriatric stereotypes contribute directly to helplessness by reinforcing such behavior. Stereotypes also minimize the chance of appropriate response outcomes relative to needs. Rolelessness, a partial result of stereotyping, leads to anomie, alienation, and lowered self-esteem. These issues are discussed and points of interaction among them are examined. The relevance to psychotherapy with older persons is outlined.
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PMID:The depressed patient: social antecedents of psychopathologic changes in the elderly. 745 87

The electroconvulsive therapy (ECT), which provokes a generalized epileptic seizure by an electrical stimulus, was first administered in 1938 and performed without anesthesia during thirty years. Nowadays, ECT is carried out using brief anesthesia (preferably methohexital) and skeletal muscle relaxation (succinylcholine) to avoid fearful complications like bone and muscle fractures. ECT is a safe treatment without absolute contraindications; the treatment risk corresponds to the risk of general anesthesia. ECT is indicated in depression, mania and schizophrenia. It plays an important role in the treatment of therapy resistant, severely ill patients with affective disorders, suicidal drive, delusional symptoms, vegetative dysregulation, inanition and catatonic symptoms. The response rate (remission or marked improvement) is about 70%. Usually ECT is performed 3 times per week, resulting in an ECT course with a total number of 6 to 12 single treatments. Within 2 or 3 weeks a substantial improvement can be expected. Further controlled studies are required with regard to antidepressive and/or antipsychotic continuation therapy after successful ECT course. Brief pulse stimulation, unilateral nondominant electrode placement and individual stimulus titration with respect to seizure threshold (EEG monitoring is required!) can minimize cognitive side effects. The apprehension that ECT could cause prolonged amnesia and structural brain damage has not been confirmed by the available scientific data. Modern brain imaging methods could elicit the until now unknown mode of action of ECT.
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PMID:[Clinical value of electroconvulsive therapy in treatment of depression]. 1063 58

In the spring of 2003, a series of sudden deaths in a group of adult lions (Panthera leo) with a previous history of depression, inanition, and lethargy, was investigated. Five animals died within 24 to 36 hours after onset of signs of disease. Serologic screening for viral disease detection was negative, evidence of parasites was not detected, and results of a complete blood count and serum biochemical analysis were within reference intervals in all lions. The most relevant lesions observed were multiple areas of necrosis and hemorrhage in the intestinal outer muscular layer, and cellulitis with an intense bloody edema in the mesenteric and the pericardial fat tissue. On the basis of the fulminant course of the disease, the gross and histologic findings, and the isolation and identification of Clostridium sordellii, a diagnosis of infectious myositis and cellulitis associated with acute clostridiosis was made. To the authors' knowledge, this is the first report of sudden death associated with C. sordellii in felines.
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PMID:Sudden death associated with Clostridium sordellii in captive lions (Panthera leo). 1667 87