Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypernatremia (sodium chloride intoxication) is described in two calves due to presumed mixing errors of oral electrolyte solutions while undergoing therapy for neonatal diarrhea. The experimental induction of hypernatremia in two clinically normal calves is also reported. Physical findings in diarrheic calves included depression, weakness, dehydration, and diarrhea. Serum sodium concentrations were found to be 171.6 mEq/l and 208.0 mEq/l, respectively. Treatment with intravenous fluids was attempted in both cases, but one calf died after 6 hours and the other calf died after 2 days and exhibited periodic convulsions before death. Experimental induction with oral administration of 1 l of electrolyte concentrate, which contained approximately 2750 mEq sodium revealed that the normal calves would willingly consume the solution as mixed with milk and develop clinical signs of hypernatremia within 6 hours of administration. Serum sodium concentrations of 176.0 and 179.8 were found in the experimental calves and coincided with the onset of overt depression and weakness, at which time they were euthanatized. Cerebrospinal fluid electrolyte analysis paralleled the serum electrolyte alterations.
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PMID:Hypernatremia in calves. 322 59

In a study of 53 medical-surgical patients who were in extended care and were consecutively referred for psychiatric evaluation, 7 (13%) of the patients had been considered to have unequivocal dementia, yet 3 of them (6% of the total or 43% of those considered demented) were found to have a false-dementing psychiatric disorder. Physical findings contributed to masking the psychopathology, which included psychotic depression with the Ganser symptom in 2 patients and hysterical pseudodementia with depression in 1 patient. Criteria that have been recommended to differentiate pseudodementia from dementia could lead to misdiagnosis in the type of case described, which suggests the need for a typology of depressive pseudodementia.
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PMID:Pseudodementia and physical findings masking significant psychopathology. 724 13

AN UNCOMMON CONDITION: Anorexia nevrosa in the prepubertal period occurs more frequently in boys than common anorexia nevrosa and is characterized by rapid major weight loss more so than by signs of bulimia. ASSOCIATED SIGNS: Depression and volitional disorders are frequently observed together with growth retardation which portends poor prognosis. The patient's personal history (eating disorders during infancy are often found) is an essential factor together with psychiatric conditions in the parents who often have major narcissistic fragility.
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PMID:[Eating disorders. Prepubertal anorexia nervosa]. 998 5

Opioid therapy is one of the most effective forms of analgesia currently in use. In the past few decades, the use of opioids as a long-term treatment for chronic pain has increased dramatically. Accompanying this upsurge in the use of long-term opioid therapy has been an increase in the occurrence of opioid associated endocrinopathy, most commonly manifested as an androgen deficiency and therefore referred to as opioid associated androgen deficiency (OPIAD). This syndrome is characterized by the presence of inappropriately low levels of gonadotropins (follicle stimulating hormone and luteinizing hormone) leading to inadequate production of sex hormones, particularly testosterone. Symptoms that may manifest in patients with OPIAD include reduced libido, erectile dysfunction, fatigue, hot flashes, and depression. Physical findings may include reduced facial and body hair, anemia, decreased muscle mass, weight gain, and osteopenia or osteoporosis. Additionally, both men and women with OPIAD may suffer from infertility. While the literature regarding OPIAD remains limited, it is apparent that OPIAD is becoming increasingly prevalent among chronic opioid consumers but often goes unrecognized. OPIAD can have a significant negative impact on the the quality of life of opioid users, and clinicians should anticipate the potential for its occurrence whenever long-term opioid prescribing is undertaken. Once diagnosed, treatment for OPIAD may be offered utilizing a number of androgen replacement therapy options including a variety of testosterone preparations and, for female patients with OPIAD, dehydroepiandrosterone (DHEA) supplementation. Follow-up evaluation of patients receiving androgen replacement therapy should include a review of any unresolved symptoms of hypogonadism, laboratory evaluation, and surveillance for potential adverse effects of androgen replacement therapy including prostate disease in males.:
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PMID:Opioid-induced androgen deficiency (OPIAD). 2323 42