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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study was conducted to investigate whether sodium valproate could affect immobility in the 'behavioral despair' test in rats. Acute (one injection), subacute (three injections) and chronic treatment with sodium valproate reduced the immobility time in this test, whereas a stimulation of motor activity in the open-field test was not observed with the same drug treatments. The anti-immobility activity of valproate was partially counteracted by the administration of bicuculline (2 mg/kg) or picrotoxin (1.4 mg/kg) before the immobility test. The data agree with previous findings from several animal models of depression of an antidepressant-like activity of GABA mimetics or agents which stimulate GABAergic function.
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PMID:Sodium valproate reduces immobility in the behavioral 'despair' test in rats. 314 7

The purpose of the present study was to induce a state of depression including both the elements of behavioral despair and chronic stress. Therefore, this study was performed under the hypothesis that a long-term exposure of rats to the experimental situation of difficult to escape from foot-shock in a Skinner box might produce animals with a state of depression containing both the elements. Male Wistar strain rats were trained to press a lever to escape from foot-shock under a fixed ratio (FR) schedule. After the training, rats were exposed daily to a schedule consisting of 20 trials (the early 10 trials, FR 5; the later 10 trials, FR 20) once a day. The exposure resulted in reduction of the number of lever presses and successful escape in FR 20. Only the animals whose number of escapes, reduced to under 20% in FR 20 were treated with psychotropic drugs once a day for 4 days. The results showed that the reduced number of escapes was most improved by antidepressants (imipramine or mianserin), but not by haloperidol and methamphetamine. Although subchronic treatment with chlordiazepoxide partially recovered the reduced escape, the efficiency of lever pressing to escape from foot-shock was lower than that with the antidepressants. The results of the present study suggest that the behavioral suppression observed in this study might include characteristics similar to a state of depression.
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PMID:Characteristics of coping behavior of rats exposed to a long-term hardly escapable aversive stimulus: a possible depression model. 319 92

In 12 children between 6 and 12 years of age who were treated as inpatients for depression (diagnosed according to the Weinberg-criteria, a child-adapted modification of DSM-III-criteria), a close relationship was found between family pathology, psychodynamics and depression. The conflicts in the interactions between the depressed children and their caregivers became evident in the children's drawings, in the Scenotest and in play therapy. In play therapy the repressed feelings of powerlessness, helplessness, disappointment, resignation and anger came to light. The children had a pseudo-stabilizing function in the family that placed too heavy demands on them, with the result that they became dependent and helpless and tended to despair. A situation developed that can be characterized as "learned helplessness" and that is a useful behavioral-physiological and neurobiological model of depression for different age groups.
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PMID:[Pediatric depression]. 324 45

This study investigated the physiological and emotional responses of patients awaiting an elective plastic surgery procedure to a 30-minute taped music program. The study replicated in part the research study of Bonny entitled "Music Rx." Values for the physiological variables of systolic blood pressure, diastolic blood pressure, pulse rate, mean arterial pressure (MAP), and double product index (DPI) were obtained before and after the music listening. These data were analyzed via a repeated measures t-test using each subject as her or his own control. The convenience sample of 10 was nonrandomized. Emotional responses were evaluated by means of an open-ended, nondirective questionnaire developed around 5 categories of depression, sadness, and despair; psychological isolation and defensiveness; anxiety; difficulty of medical management; and preoccupation with pain. Process recordings and documented verbal and body language were used before and after the music to identify themes and mood states expressed by patients. Every physiological variable decreased in value at the less than .001 level of significance. The most significant emotional effect appeared to be an experienced shift in patients' awareness toward a more relaxed, calm state. The most critical conclusion is that music listening appeared to effect desirable pattern shifts in physiological and emotional states in the presurgical setting for those patients studied.
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PMID:Music Rx: physiological and emotional responses to taped music programs of preoperative patients awaiting plastic surgery. 330 95

Seventy-three chronic pain patients with elevated MMPI Schizophrenia (Sc) scale scores (T score greater than 70) were compared with 55 psychotic and 87 non-psychotic psychiatric patients with elevated Sc scores to examine group differences in item content patterns on the Harris and Lingoes subscales. Chronic pain patients evidenced lower scores on all Harris and Lingoes Sc subscales, except for the Bizarre Sensory Experiences subscale on which they scored significantly higher than the psychiatric groups. Results demonstrate that Sc is elevated in many chronic pain patients because they endorse somatic symptoms and items suggestive of depression and inertia, whereas psychotics endorse more items reflecting bizarre and disordered thinking, social alienation and defective inhibition, and non-psychiatric patients endorse more depression, despair, thought disorganization and social alienation. These data suggest that high Sc scores of many chronic pain patients reflect symptoms and sequelae of their physical problems, and do not necessarily reflect severe psychopathology.
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PMID:Risk of misinterpretation of MMPI Schizophrenia scale elevations in chronic pain patients. 336 57

In this study, we attempted to explore the construct validity of the Kendrick Battery by using an American sample and psychometric tests as indexes of diffuse organicity, depression, and normality. Institutionalized residents (N = 53) were tested twice (6-week interval). When organicity was defined by disorientation and memory deficits, then both the Object Learning test and the Digit Copying test were accurate in differentiating preestablished criterion groups. When organicity was defined more broadly, including sensorimotor function, the Digit Copying test alone was more accurate when depression was defined in terms of irritability, restlessness, and despair. These data suggest that although the Kendrick scales appeared to be sensitive to organicity and depression in this sample, their validity varied with the criteria for each when such were defined psychometrically.
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PMID:Construct validity of the Kendrick Battery with institutionalized aged. 376 Dec 19

The present study was performed in order to evaluate the role of brain noradrenergic system of the locus coeruleus (LC) in mediating the effect of desipramine (DMI) in the behavioral despair (immobility) induced by forced swim in rats. Both single and repetitive doses of DMI significantly reduced the immobility. The effect of single dose of drug was reduced in LC lesioned rats. On the other hand, lesions failed to influence the action of repetitive doses of DMI. A lesion of the LC alone failed to influence animals' behavior in the immobility test. Electrical stimulation of the LC (either unilateral or bilateral) significantly reduced the immobility i.e. produced an effect similar to that produced by DMI. The possible involvement of the LC in action of DMI and mechanisms of depression is discussed.
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PMID:Studies on the locus coeruleus system in an animal model for antidepressive activity. 609 90

The atypical neuroleptic sulpiride is also prescribed for depression because of its activating effect. However, such an effect does not necessarily imply an action identical to that of classical antidepressants, and a laboratory comparison of the neuroleptic and antidepressant activities of sulpiride may contribute to a better definition of its psychotherapeutic profile. Sulpiride isomers were studied in the rat in four behavioural models of depression which are thought to be influenced by neuroleptics in different ways. Desipramine (imipramine) and haloperidol were employed in each test as a standard antidepressant and neuroleptic, respectively. The four tests were: 1) prevention of apomorphine-induced sedation: 2) antagonism of apomorphine-induced hypothermia; 3) behavioural despair (swim test); 4) learned helplessness ( FR2 lever pressing escape). Desipramine ameliorated behaviour in all tests; haloperidol ameliorated the response to test 1, influenced that to test 2 in a neuroleptic-like way and worsened the responses to tests 3 and 4. (-)-Sulpiride worked in a similar way to haloperidol in all tests. (+)-Sulpiride significantly and dose-dependently ameliorated the responses to test 3 and was inactive in the others. No conclusion was drawn from test 1 owing to its lack of specificity; the results of the remaining tests indicated a neuroleptic profile of (-)-sulpiride and suggested a potential "antidepressant" activity of (+)-sulpiride which merits further investigation.
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PMID:Antidepressant versus neuroleptic activities of sulpiride isomers on four animal models of depression. 614 54

Depression and faith are closely connected in Job. Struck by heavy buffets of fate and suffering from an incurable disease Job despairs of God. He ist no longer able to connect his suffering with his former experience of God. Whereas his friends exhort and rebuke him, Job feels to be innocent and expresses his despair in continuous laments and accusations in order to challenge God to give an answer. His ability "to transcend", his hope of "God, his friend" against "God, his enemy" saves him from resigned self-negation and total paralysis. In the care of Job it is safe to assume that there is no melancholy nor endogeneous depression, during which the power of faith and hope is often extinguished. The problem to what extent the category of hope and the ability of "transcending" in heaviest suffering and deep depression become especially relevant under the psychotherapeutic aspect, is an important question to be put to psychiatry and psychotherapy.
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PMID:[Depression and faith in Job]. 635 37

The anti-depressive effects of thyrotropin releasing hormone (TRH) and its analogues (DN-1417: gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate; MK-771: L-pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide) were examined in behavioral despair rats, an animal model of depression. TRH, DN-1417, MK-771, amitriptyline and diazepam were injected three times after the first forced swimming. One hr after the last injection, a 5-min swimming test was performed. Experimental animals were placed in a Hall's type open-field apparatus immediately before and after the 5-min test, and their locomotor activities were determined. No significant difference was noted in the locomotor activity immediately before the 5-min test among any group. In the 5-min swimming test, TRH, DN-1417 and MK-771 caused a dose-dependent decrease in immobility, showing an anti-depressive effect similar to amitriptyline. Diazepam showed no difference compared with the control group. After the swimming test, locomotor activity remarkably decreased in the control rats, while decreased locomotor activity was partially prevented in the TRH, DN-1417, MK-771 and amitriptyline treated rats which exhibited active movement not only during the swimming period but also after it. In terms of the minimum effective dose, TRH and DN-1417 seemed to be of similar potency, while MK-771 was 40-fold stronger than TRH. An examination of a possible correlation between the cross-reactivity of TRH analogues in a radioreceptor assay and the effects of the analogues on despair rats suggested that the structure-binding relationship was proportional to the structure-activity relationship.
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PMID:Potential anti-depressive effects of thyrotropin releasing hormone (TRH) and its analogues. 643 97


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