Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Glucocorticoid therapy causes psychiatric side effects in many patients. Although psychiatric side effects occur most commonly in women and middle-aged patients, no clinical features have been identified to predict which patients are at risk. The most frequent side effects are mood changes ranging from mild euphoria to hypomania, but other reactions, including depression, dementia and psychosis, are possible. The incidence of psychiatric side effects is directly related to dosage. The mechanism by which glucocorticoids produce psychiatric symptoms is probably multifactorial, including both direct and indirect effects on the brain. Psychiatric symptoms usually resolve with dosage reduction or controlled withdrawal of glucocorticoids, but antipsychotic medication may be indicated if symptoms are severe or prolonged.
 ...
PMID:Adverse psychiatric effects of systemic glucocorticoid therapy. 144 65

In a longitudinal study of personality, 66 women completed the Cesarec Marke Personality Schedule, a Swedish personality inventory, in order to asses their psychogenic needs at the age of 15 and 25. Psychiatric symptoms and a number of background variables were assessed independently after the completion of the Cesarec Marke Personality Schedule, with the aim of examining whether traits and background variables were related to psychiatric symptoms. The psychogenic needs Defence of Status and Guilt Feelings at the age of 15 were positively and significantly related to depressive and anxiety symptoms and high score on psychiatric morbidity in general. The psychogenic needs Defence of Status, Guilt Feelings and Succourance at the age of 25 were significantly related to the symptom constructs Somatization, Interpersonal-sensitivity, Depression, Anxiety-phobia, and General Morbidity. Subjects with a low score of psychiatric symptoms differed from high scoring subjects by having been raised by older parents, experienced a secure childhood, better relationships with siblings and peers, and a longer education. It may be hypothesized that high scores on Defence of Status and Guilt Feelings in combination with less favourable background variables may constitute a vulnerability factor for depression and anxiety.
 ...
PMID:Psychogenic needs and psychiatric symptoms in young Swedish women. 157 4

Sixty surviving patients from a community-based stroke register who had CT scan evidence of a single brain lesion and neurological signs appropriate to it were interviewed three to five years following their first-ever stroke. Mood disorder (anxiety and depression), physical disability, and intellectual impairment were assessed using standardized measures. The position and volume of the brain lesion was determined from CT scans performed soon after the stroke. The prevalence of depressive disorder was lower in this sample than that reported in previous studies (DSM-IIIR major depression 8.3%; all DSM-IIIR depressive disorders 18.3%). Reports by other workers for an association of depressive disorder either with left-sided brain lesions, or with anteriorly placed lesions in the left cerebral hemisphere, were not supported. Neither was there evidence of a correlation between symptom score and proximity of the lesion to the anterior pole of the left cerebral hemisphere. Psychiatric symptom scores were however greater with larger volume brain lesions. Anxiety disorders, especially agoraphobia, were relatively common (20% if diagnosed in the presence of depressive disorder), but were not related to lesion location or volume.
 ...
PMID:Mood disorders in long-term survivors of stroke: associations with brain lesion location and volume. 228 90

A series of 195 cases of Wilson's disease were assessed retrospectively on a range of variables, including psychiatric, neurologic, and hepatic symptoms, and biochemical data as recorded at first admission to a specialist clinic. Ninety-nine patients (51%) were rated as displaying some evidence of psychopathologic features, and 39 (20%) had seen a psychiatrist before the diagnosis of Wilson's disease. The most common psychiatric features were abnormal behavior and personality change, although depression and cognitive impairment were also rated frequently. Schizophrenialike psychoses were rare, apparently occurring at no more than chance frequency. Psychiatric symptoms were related to neurologic rather than hepatic symptoms, and certain symptoms (incongruous behavior, irritability, and personality change) had a particularly significant relationship with bulbar and dystonic disorders but not with tremor. Psychiatric manifestations are important in Wilson's disease, and many of the psychopathologic features seem to have an organic basis.
 ...
PMID:Wilson's disease. Psychiatric symptoms in 195 cases. 258 27

Psychiatric symptoms among medical in-patients in an Indian hospital were assessed: the SRQ was used as a screening instrument, and those with probable psychiatric disorders were given the PSE and MSE, for further, detailed assessment. The prevalence of psychiatric disorders was 34%, with a further 15% reporting distressing psychiatric symptoms only. The most frequent complaints were delirium and adjustment disorders. They were largely associated with connective tissue, as well as cardiovascular and endocrine, disorders, and were characterised by depression, worrying and irritability. The reliability of the SRQ varied with the cut-off score, which gave optimal specificity and sensitivity when set at 9.
 ...
PMID:Psychiatric disorders among medical in-patients in an Indian hospital. 259 Jul 81

Psychiatric symptoms are well recognized as a feature of patients with primary hyperparathyroidism. We have applied a standardized psychiatric interview to 15 patients before and after surgery. Thirteen had a lower 'psychiatric score' (less psychiatric morbidity) after surgery and improvements were particularly seen in symptoms of fatigue, depression, irritability, sleep disturbance and lack of concentration. The levels of intellectual impairment and of anxiety were unchanged after surgery. The 'psychiatric scores' in an additional group of 21 hyperparathyroid patients, in whom a decision to treat conservatively had been made independently, were similar to those in the surgically treated patients after surgery. Among all the untreated patients no relationship was found between overall 'psychiatric score' and serum levels of calcium or parathyrin.
 ...
PMID:Psychiatric morbidity in primary hyperparathyroidism. 260 90

Appropriate management of cancer pain is essential and requires a multidisciplinary approach that includes a major role for a psychologist and/or psychiatrist. An increased incidence of psychiatric disturbance, in particular, anxiety and depression, is found in patients with pain. Psychiatric symptoms in patients with cancer pain must be initially viewed as a consequence of uncontrolled pain. Personality factors may be quite distorted by the presence of pain, and its relief often results in the disappearance of a perceived psychiatric disorder. Reassessment after pain control is imperative. Optimal treatment of cancer pain includes pharmacologic, psychologic, behavioral, anesthetic, stimulatory, and rehabilitative approaches, often in combination. Cognitive and behavioral interventions, such as relaxation, imagery, hypnosis, distraction, and biofeedback, are effective as part of a comprehensive multimodal approach and must never be used as a substitute for appropriate analgesic management of cancer pain. Psychotropic drugs, particularly the tricyclic antidepressants, are useful as adjuvant analgesic agents in the pharmacologic management of cancer pain.
 ...
PMID:Psychiatric management of cancer pain. 265 68

Psychiatric symptoms in Alzheimer's disease are not specific: anxiety, agitation, depression, memory disorders, mental confusion. Of these disorders, depression is the most accessible of these to pharmacological treatment; agitation, however, raises the institutional problem. Throughout the inexorable evolution of the disease, the psychiatrist has to pay attention to the global situation: medical, social and legal.
 ...
PMID:Psychiatrists and Alzheimer's disease. 281 37

Psychiatric symptoms among patients with acquired immune deficiency syndrome (AIDS) may be functional reactions to contracting a fatal and stigmatizing disease or may be secondary to malignancies and opportunistic infections in the central nervous system (CNS). More recent evidence indicates that HTLV-III, the virus that causes AIDS, directly infects the CNS and may cause psychiatric symptoms before signs of immunodeficiency, cognitive impairment, or neurological abnormalities emerge. AIDS-related organic mental syndromes may mimic functional disorders such as chronic mild depression and acute psychosis. Both of these common presentations are illustrated with detailed case reports, and diagnostic and management guidelines are provided.
 ...
PMID:Neuropsychiatric manifestations of AIDS-spectrum disorders. 300 46

Psychiatric symptoms may be the only clue to the presence of a brain tumor. Careful physical, neurologic and psychiatric examinations will reveal the diagnosis. Affective and schizophrenia-like psychoses are related to dysfunctions of the right and left hemispheres, respectively. Lesions of the temporal lobes commonly cause depression. Psychotropic medications may improve symptoms in the presence of tumor. There is no clinical method of localizing or excluding a brain tumor by its psychiatric manifestations.
 ...
PMID:Psychiatric symptoms and brain tumor. 301 15


1 2 3 4 5 6 7 8 9 10 Next >>