Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To investigate effects of epidural morphine and pentazocine on postoperative pain, eighty-eight women who have undergone gynecological abdominal surgery were studied. 1) As for onset of analgesia, there was statistically no significant difference between morphine and pentazocine. 2) The duration of analgesic effect of epidural morphine significantly lasted longer than epidural pentazocine. The duration of analgesic effect of epidural morphine showed a tendency to be longer in the groups of morphine 4 or 6mg than 2mg, but there was no significant difference between the groups of morphine 4 and 6mg. 3) On the postoperative first discharge of bowel gas, there was statistically no significant difference between morphine and pentazocine. The onset time of the gas discharge showed a tendency to be longer in the groups of morphine 4 or 6mg than 2mg. In case of pentazocine, it may be longer in 15mg than 10mg. 4) As for side effects, nausea, vomiting, thirsty, redness of the face and sweating were mainly observed. However, respiratory depression as well as sensory and motor disturbance which frequently observed after epidural injections of the local anesthetic were not recognized in these procedures. But circulatory depression and urinary retention were observed in only one cases of epidural morphine.
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PMID:[Studies on comparison of the postoperative analgesic method between epidural morphine hydrochloride and pentazocine]. 689 14

Cortical spreading depression (SD) may produce some symptoms of the aura of classical migraine but it is less probable that it can account for the headache. The aversiveness of SD was examined in unanesthetized rats. In Exp. 1, rats with implanted cortical cannulae were confined in the dark compartment of the step-through apparatus and repeated waves of SD were elicited in one hemisphere. After two such training sessions the rats did not evince passive avoidance of the compartment associated with cortical SD. In Exp. 2, thirsty rats with implanted hippocampal electrodes were trained to drink from two different spouts A and B. Hippocampal SD was elicited when the animal was drinking from spout A but not from spout B. Drinking was interrupted shortly after appearance of the SD wave and gradually recovered over the subsequent 10 min, but up to ten spout A-SD pairings did not change the animal's preference for spout A. It is concluded that cortical or hippocampal SD has no immediate or delayed aversive consequences.
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PMID:Rats do not experience cortical or hippocampal spreading depression as aversive. 847 90

In dermatology, psychotropics are sometimes useful. But it is not still popular in clinical dermatology. It is recommended to use them for the patients who have psychosomatic aspect, anxiety and depression due to skin disease. Psychotropics are also useful to alleviate the sensation of itch. Trichotillomania and excess scratch are treated with antidepressants, anticonvulsants or antipsychotics. Cutaneous dysesthesia and delusional parasitosis are treated with antipsychotics. In prescribing benzodiazepines and hypnotics, we have to check abuse and dependency. Decrease of dosage should be made gradually. Antidepressants, anticonvulsants (except barbiturates) and antipsychotics have no dependency. They are much easily used than benzodiazepines. Drowsy and thirsty are main side effects that antihistamines also have. It should be noticed to use both simultaneously.
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PMID:[Psychotropics in dermatology]. 2241 3

Objective To observe distribution laws and features of syndrome types of Chinese medicine (CM) in hyperlipidemia patients of Han, Uyghur, Kazakh nationalities in Xinjiang Uyghur Auton- omous Region. Methods Using cluster random sampling, 1 410 hyperlipidemia patients (18 -70 years old ) were recruited from Urumqi, Turpan, Altay, Ili, Aksu, Hetian in Xinjiang Uyghur Autonomous Re- gion. The general condition, susceptible factors, classification of blood lipids, complications, syndromes of CM, tongue figure, etc. clinical data were investigated using self-formulated Epidemiological Investiga- tion Questionnaire on Susceptible Factors in Different Nationalities of Hyperlipemia Patients in Xinjiang (abbreviated as Questionnaire thereafter). Factor analysis and cluster analysis were performed. Results Cronbach's coefficient for the 54 syndrome items in Questionnaire was 0.891, Kaiser-Meyer-Olkin (KMO) 0. 897, Sig <0.05 in Bartlett's sphericity test. Seventeen common factors were obtained using principal component analysis (PCA). Totally 54 common symptoms of hyperlipidemia were screened, which were then divided into 17 groups with 1 -6 symptoms in each group. F4 (soreness and weakness of waist and knees, sour pain in joints and muscles, body numbness, heavy body sensation, cold limbs), F5 (frequent and clear nocturia, dysuria,-dribble of urine, frequent urination at night), F10 (thirsty, no desire for water, tastelessness, hydroadipsia) , F12 (a white complexion with puffiness, hid- ing fever, hypoactive sexual desire) , and F17 (enuresis) were merged as Shen yang deficiency (SYD) ; F2 (fatigue, drowsiness, depression, spiritlessness, fatigue and disinclination to talk) and F15 (poor ap- petite) were merged as Pi-qi deficiency (PQD) ; F3 (dry mouth and dry pharynx, thirsty, propensity for water, bitter mouth, greasy mouth, stingy mouth, irritability and upset) and F16 (dark red tongue proper, greasy tongue fur) were merged as damp-heat trapped in Pi (DHTP). Results of cluster analysis showed that Pi-Shen deficiency (PSD) was most often seen in hyperlipidemia, and main syndrome types were sequenced from high to low as Pi-Shen deficiency type (46. 2%, 652/1 410) , blockage of cardiac vessels type ( 31. 1% , 438/1 410 ), phlegm and blood stasis internal resistance type ( 13. 3% , 187/1 410), Pi-deficiency induced damp abundance type (8. 3%, 123/1 410), Gan-Shen yin deficiency type (0. 7%, 10/1 410). Conclusions Deficiency syndrome was dominant in hyperlipidemia patients of Xinjiang Uyghur Autonomous Region. Phlegm turbidity, damp heat, and etc. were often complicated. The complex situation was manifested to be involved in multiple organs, qi-blood-fluid mixed disease.
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PMID:[Syndrome Features of Chinese Medicine in Hyperlipidemia Patients of Han, Uyghur, Kazakh Na- tionalities in Xinjiang Uyghur Autonomous Region]. 3064 Sep 86