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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Covariance studies of objective depression measures have concentrated on total scores. This approach is relatively insensitive in specifying whether these instruments measure the same sub-aspects of depression. To investigate this question, a factor analysis was performed on the items of the Beck Depression Inventory and the Zung Self-Rating Depression Scale and lists A, B, C, and D of the Lubin Depression Adjective Check Lists. Ss were 91 college students and 29 correctional institution inmates. Four clearly interpretable multimeasure factors resulted from a Varimax rotation. The most salient factor was labeled "Depression: Affective Malaise." Earlier studies also have shown this to be a dominant and reliable dimension of depression. The other factors were: Suicidal Ambivalence," "Appetite-Weight Loss," and "Fatigability." Females showed greater Fatigability associated with depression. Factors specific to the Beck and Zung measures also were found, which suggests that the different emphases of these instruments, intensity/severity vs. frequency of symptoms, may contribute very specific depression indicators. This may indicate that both intensity and frequency of symptoms ought to be considered to obtain a "best" objective measure of depression.
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PMID:Independent dimensions of depression: a factor analysis of three self-report depression measures. 27 Apr 82

Forty-five patients with Parkinson's disease (PD) without dementia were studied. Duration of disease was 6,02+/-3,47 years. The following scales were used: PFS-16, UPDRS part 2, the Beck Depression Scale, PDSS and the Epworth Sleepiness Scale. Fatigability is thought to be one of three presentations of PD that restrict daily activities in 64% of patients. The integrated assessment of fatigability was significantly correlated with the total depression score and PDSS scores. The treatment with mirapex resulted in the reduction of fatigability that was not correlated with changes in motor functioning, depression, sleep disorders. Fatigability is a symptom that significantly disturbs daily activities of patients. The author suggests that fatigability is more associated with nervous and psychiatric symptoms than with a severity of movement disorders. The lack of significant association between dynamics of fatigability and changes in other parameters of nervous and psychiatric functions during the therapy plausibly implies the separate genesis of this symptom.
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PMID:[Fatigability in Parkinson's disease]. 1977 Aug 28