Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A condition commonly seen after motor vehicle accidents is studied. This is the "late whiplash" syndrome, which is defined as a collection of symptoms and disabilities seen more than six months after a neck injury occurring in a motor vehicle accident. A series of 300 cases is examined. With the use of factor analysis the syndrome is defined as consisting of headache, neckache, neck stiffness, and depression, as well as anxiety, all of which are strongly correlated with each other. There is, on the other hand, a poor correlation with physical or radiological abnormalities. The condition is common in women, especially in the 21 to 40 years' distribution. It is shown that social variables may be relevant n the production of the syndrome.
 ...
PMID:The late whiplash syndrome. 693 81

We report 37-year-old man admitted to the psychiatric ward with acute depression. Antidepressive medications were initiated including: promethazine hydrochloride, hydroxyzine hydrochloride, lorazepam and haloperidol. In an attempt to control his depression, doctors increased the dose of haloperidol. Five days later he developed fever, cough, confusion and he was unable to eat. Accordingly, he was transferred to the medical ward for further assessment. On examination he was febrile, confused, there was neck stiffness and generalized rigidity with flexor planters. Both serum myoglobin and creatine kinase level were elevated. The urine myoglobin test result was positive. He was diagnosed with neuroleptic malignant syndrome. Dantrolene was started for 3 days, followed by bromocriptine. The clinical syndrome resolved over the next couple of days.
 ...
PMID:Neuroleptic malignant syndrome. 2226 59