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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Depressive symptoms present in 43 patients with unipolar nondelusional melancholia were studied to determine which symptoms were the best measures of response to desipramine hydrochloride. An extended Hamilton Depression Scale was used to identify symptoms that were present frequently. We then determined which symptoms improved in direct relation to achievement of therapeutic plasma desipramine concentrations, using multiple regression analysis to account for pretreatment symptom severity. In ten symptoms, improvement was significantly associated with desipramine treatment. These ten symptoms seem to be the best measure of drug response during tricyclic antidepressant treatment in patients with nondelusional melancholia.
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PMID:Drug-responsive symptoms in melancholia. 673 25

This study examines the extent to which depressive symptoms in female nursing students are affected by specific stressors and coping styles. Three hypotheses were examined for differences in symptoms of depression scores and a model was tested for predicting depression in female nursing students. Responses were gathered from three questionnaires (Hassles and Uplifts Scales, Symptoms of Stress Inventory, and Coping Styles) from 408 female baccalaureate, master's and doctoral students from a major Midwest research university. Symptoms of depression were not significantly different among the students and were as high as a comparative group of stress management clients. Path analysis was used to examine the patterns of stressors (hassles, uplifts, personal and student-related stress), coping (coping styles, habits, quitting school, and drug use), and a biological factor (depression around the menstrual cycle) that predicted symptoms of depression. All hypothesized variables had direct paths to symptoms of depression; the path model explained 58% of the variance. Results from this study support the biological and psychological theories of depression in women and raise important questions of particular relevance to women, nursing students and educators.
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PMID:Symptoms of depression among female nursing students. 748 68

A possible method of reducing the delay in antidepressant response is to use S-adenosyl-L-methionine (SAMe), a naturally occurring compound that appears to have a rapid onset of effect in the treatment of depression. In this open, multicenter study, 195 patients were given 400 mg of SAMe, administered parenterally, for 15 days. Depressive symptoms remitted after both 7 and 15 days of treatment with SAMe, and no serious adverse events were reported. Further studies with a double-blind design are needed to confirm this preliminary indication that SAMe is a relatively safe and fast-acting antidepressant.
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PMID:Rapidity of onset of the antidepressant effect of parenteral S-adenosyl-L-methionine. 756 52

Depressive symptoms estimated by the Beck Depression Inventory (BDI) were examined in winter and summer in a total of 242 Japanese adults staying less than 2 years or longer than 10 years in Stockholm, where the length of daylight changes dramatically throughout the winter and summer seasons. In spite of the difference in the period of residency, both groups of subjects showed more mental and somatic depressive symptoms in the winter than in the summer. Moreover, the winter BDI score of long stayers was significantly higher than that of short stayers. Accordingly, our results suggest that, although seasonal mood variation is essentially produced by a chronobiological factor, Swedish lifestyle to which long stayers have been accustomed also influences the seasonal mood variation.
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PMID:Seasonal mood variation among Japanese residents of Stockholm. 757 48

The prevention of major depression is an important research goal which deserves increased attention. Depressive symptoms and disorders are particularly common in primary care patients and have a negative impact on functioning and well-being comparable with other major chronic medical conditions. The San Francisco Depression Prevention Research project conducted a randomized, controlled, prevention trial to demonstrate the feasibility of implementing such research in a public sector setting serving low-income, predominantly minority individuals: 150 primary care patients free from depression or other major mental disorders were randomized to an experimental cognitive-behavioral intervention or to a control condition. The experimental intervention group reported a significantly greater reduction in depressive levels. Decline in depressive levels was significantly mediated by decline in the frequency of negative conditions. Group differences in the number of new episodes (incidence) of major depression did not reach significance during the 1-year trial. We conclude that depression prevention trials in public sector primary care settings are feasible, and that depressive symptoms can be reduced even in low-income, minority populations. To conduct randomized prevention trials that can test effects on incidence with sufficient statistical power, subgroups at greater imminent risk have to be identified.
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PMID:Prevention of depression with primary care patients: a randomized controlled trial. 757 30

The aim of the present study is to investigate the task-specific work stressors of IS (Information Systems) managers and to analyze the effect of these work stressors on depressive symptoms among these managers. A questionnaire including 33 items on work stressor was designed. Three hundreds of samples were gathered. The response-rate was 66.4%. Factor analysis suggested that these 33 items were categorized into 8 factors; job-overload, project-management, mental-rewards, job-latitude, communication with users, career development, technical difficulty, and work-environment. Eight work stressor scores were constructed using this Factor analysis. Using the 8 stressor-scores, and 6 items of background data, multiple regression analysis was conducted on the depressive symptoms score. Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression (CES-D) scale. The results showed that the factors of project-management, mental-rewards, and job-overload had significant effect on depressive symptoms (p < 0.01). It is indicated for the first time that software project management affects depressive symptoms in systems managers.
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PMID:Work stress and depressive symptoms among Japanese information systems managers. 759 52

Depressive symptoms may arise as part of the normative response to the onset or progression of serious medical illness such as end-stage renal disease (ESRD). However, persistent and severe depressive symptoms are not usual in such patients and may indicate the need for a clinical intervention, whether or not a psychiatric disorder is present. Patients with more severe medical illness, a prior history of depression, and low social support are at risk to develop the syndrome of major depression. Problems in diagnosing this disorder in ESRD are discussed. Accurate diagnosis is important because of the availability of effective antidepressant treatments. However, interventions may also be indicated as prevention or treatment for patients with subthreshold depressive symptoms.
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PMID:Depression in patients with end-stage renal disease: psychopathology or normative response? 761 25

The cognitive diathesis-stress model of depression was tested in a sample of 439 children in grades 5 and 6. Attributional style and cognitions about academic competence and control over achievement were assessed before the occurrence of a potentially stressful event--receiving unacceptable grades on a report card. Depressive symptoms were assessed 1 week before the event, the morning after, and 5 days later. Replicating G. I. Metalsky, L. J. Halberstadt, and L. Y. Abramson (1987), stressor level and negative cognitions predicted depressive symptoms the morning after the event, controlling for initial symptom levels. Depressive symptoms 5 days later were predicted by the interactions of negative cognitions with stressors, supporting a cognitive diathesis-stress model. Students who reported a negative explanatory style or lack of academic control and competence expressed more distress after receiving unacceptable grades than did students without such cognitions.
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PMID:A test of the cognitive diathesis-stress model of depression in children: academic stressors, attributional style, perceived competence, and control. 764 10

Symptoms of depression and anxiety were measured in a prospective follow-up study of 36 cancer patients before and during chemotherapy by means of the Hamilton rating scales and the Melancholia Scale. These scales proved useful in the examined population. Moderate or severe depression was seen in almost half of the patients before chemotherapy, but this figure decreased during follow-up. The symptomatology resembled that of primary depression, and the brief rating scales for depression seemed suitable for screening purpose. Problems in identifying morbid states of anxiety and depression are discussed.
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PMID:[Symptoms of depression in cancer patients undergoing chemotherapy]. 772 62

The present study examined the relationships between depressive symptoms and everyday social interaction in a nonclinical population. Depressive symptoms were measured using the Center for Epidemiological Studies Depression Scale, and social interaction was measured using a variant of the Rochester Interaction Record. People who were classified as at risk for depression had less rewarding interactions than people who were not at risk. Depressive symptoms and interaction quantity and quality were negatively correlated for participants above the cutpoint, whereas they were uncorrelated for those below the at-risk cutpoint. The results also suggested that, compared with nondepressed people, depressed people derive more rewards from interactions with their closest opposite-sex friends, relative to the rewards they derive from interactions with other opposite-sex friends.
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PMID:Depression and everyday social interaction. 781 3


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