Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy-seven patients aged more than 60 years from the iodine deficiency area of southern Lower Saxony with hyperthyroidism, diagnosed by assessment of thyroid parameters, showed a nonspecific disease picture with surprising frequency when compared with younger patients. Predominant characteristics were weight loss (86%), general weakness (78%), tachycardia (74%), reduced appetite (66%), exertional dyspnoea (60%), apathy, lack of initiative or depression (48%), and uncharacteristic abdominal complaints (20%). A goitre was not palpable in 30 patients (39%). Laboratory diagnosis was hampered by relative or absolute TBG deficiency and conversion inhibition in the form of a low-T3 syndrome as evidence of non-thyroidal changes in generalised disorders. Neither thyroxine nor triiodothyronine were increased in ten patients (13%). Only by additional routine estimation of the thyroxine-binding index (T3 in vitro test) as indicator of free binding capacity could the diagnosis be ascertained in these cases. The poor prognosis be ascertained in these cases. The poor prognosis of hyperthyroidism in the older age group necessitates generous use of specific diagnostic laboratory investigations in cases with suspicious symptoms.
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PMID:[Diagnostic problems of hyperthyroidism in the older age group (author's transl)]. 679 Feb 60

Methylphenidate hydrochloride (Ritalin) has been used to treat both depression and apathy. Although it can be useful for apathy, there is little reason to prefer it over a tricyclic antidepressant in the treatment of depression. Side effects and drug interactions are generally not limiting, and methylphenidate is tentatively recommended for the patient whose apathy is jeopardizing his care.
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PMID:Methylphenidate in depression and states of apathy. 701 85

The intercorrelations of five different factor-analytically derived syndrome solutions of the AMP-system were computed. The syndromes were based on the psychopathological symptoms of 2,269 patients on admission to the psychiatric clinic of the Free University of Berlin. The syndromes which were similar in content in the solutions of different clinics could be shown to intercorrelate quite highly. Only the different syndromes of stupor and obsession-compulsion did not show the same high degree of similarity. Between the syndromes of the solution of one clinic as well as between the solutions of different clinics high intercorrelations were computed comparing non-corresponding syndromes; this could be demonstrated for the syndromes of mania with hostility and of apathy with stupor and depression. For building syndromes in the AMDP-system in the near future the aim for independence of the syndromatic scales seems to be important.
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PMID:[A statistical comparison of the different factor analyses of the AMP-system (author's transl)]. 708 61

Previous research has shown chronic pain patients to have elevated scores on the Hypochondriasis (Hs), Depression (D), and Hysteria (Hy) scales of the MMPI. While high scores on these scales are generally considered to reflect neurotic symptomatology and emotional disturbance, their interpretation is more ambiguous within this patient population. Item-level and subscale analyses of these scales and the K scale (a measure of defensiveness) were performed in order to clarify the meaning of these elevated scores. In these analyses a pain group's endorsement of each item was compared with the responses of two control groups, one a general medical patient sample, the other consisting of first year college students. Items showing group endorsement differences of 10% or greater were interpreted as providing significant information about the pain sample. Analysis of the Hs items indicated that a significant portion of the pain group exhibited the vague and diffuse somatic complaining characteristic of hypochondriasis. While the D scale results revealed a considerable amount of depressive symptomatology (such as sleep disturbance, poor self-esteem, apathy, and feelings of unhappiness, anxiety, and dissatisfaction), they did not support the notion that pain patients have the personality characteristics associated with severe depression. Analyses of the Hy and K scales indicated that the pain patients were no more defensive than were either of the control groups, and that their responses did not conform to the classic hysterical pattern.
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PMID:Neurotic tendencies among chronic pain patients: an MMPI item analysis. 716 39

To investigate the tension reduction hypothesis of alcohol use in the natural environment and with several forms of tension, 36 heavy social drinking young men kept daily records of their drinking, anxiety, unhappiness, and anger for 3 months and for 1 month from 6 to 7 months from the start of the study. No significant correlations were found between the frequency and intensity of any of the daily moods and drinking rates or intoxication frequency, either concurrently or within a few days or weeks. Drinking was also unrelated to general trait anxiety, depression, stressful life experiences, and locus of control. However, trait social anxiety had a consistent but unexpected relationship to drinking--the less socially anxious the men were, the more they drank over time. Drinking and/or intoxication rates were also related to having more social supports and to traditionally masculine interests. The results cast doubt on the tension reduction hypothesis and suggest that having a strong social group and indifference to the social consequences of intoxication are more important predictors of heavy drinking rates in young social drinking men.
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PMID:Social anxiety, daily moods, and alcohol use over time among heavy social drinking men. 718 Jun 28

Hypothyroidism can often be misdiagnosed as psychiatric illness. The hypothyroid patient may present with depression, an organic mental disorder, apathy and/or frank psychosis (usually with paranoid symptoms). Psychiatric manifestations of the endocrinopathy will abate with thyroid hormone replacement therapy, unless the disease state has been sufficiently prolonged to cause some irreversible brain damage. This irreversibility mandates prompt diagnosis and specific hormonal replacement therapy. Thus, thyroid function screening is recommended for patients presenting with depression, psychosis or organic mental disorder.
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PMID:Psychiatric presentations of hypothyroidism. 723 30

Information about perceptions of labour and delivery and about immediate emotional reactions to their newborn babies was obtained from two groups of primiparous women (n = 112 and n = 41) and from 40 multiparae. About 40 per cent of primiparae and 25 per cent of multiparae recalled that their predominant emotional reaction when holding their babies for the very first time had been one of indifference. Maternal affection was more likely to be lacking after delivery if the mother had had a forewater amniotomy and had, in addition, either experienced a painful and unpleasant labour or been given more than 125 mg of pethidine. Most mothers developed affection for their babies within a week of delivery and, in all groups of subjects, no longer term adverse effects were seen, such as post-natal depression or aggressive impulses directed at the baby. Three months post-natally it was, however, found that a mother was more likely to express feelings of dislike or indifference towards her baby if she was clinically depressed at the time.
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PMID:Delayed onset of maternal affection after childbirth. 738 42

An elderly patient with thyrotoxicosis complicated by lack of classical clinical signs and normal conventional tests is described. The picture was compounded by development of apathy and depression. This is the second case report of apathetic T3 thyrotoxicosis in the literature. Such a clinical entity can easily be overlooked, but represents one of the treatable disorders of 'old age depression'.
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PMID:T3 toxicosis presented by depression in an elderly woman. 744 7

The author presents a review of literature dealing with issues concerning unemployment related health effects. Studies of this problem explicitly show that the loss of the job exerts a detrimental health effect. A number of other factors decide about the significance of this relationship. The change from being employed to unemployment affects mostly mental health. First symptoms appear together with the danger of losing the job. Unemployment can evoke apathy, fear or frustration and then it leads to more serious disorders such as neuroses, depression and so forth. It can be also responsible for suicidal attempts. These disorders are usually associated with somatic complaints. Stress evoked by the loss of the job is the major factor affecting the health state of an unemployed person. The loss of income and social status is another important factor. Many authors turn particular attention to a growing intensity of all negative effects of unemployment if it lasts for a long period of time.
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PMID:[Health effects of unemployment]. 747 54

Thyroid function was assessed in seventy two patients with various types of mycetoma. There was no evidence of clinical or biochemical thyroid dysfunction in these patients. The symptoms encountered in some of the mycetoma patients mimic those of hypothyroidism should be attributed to other factors possibly mental depression and apathy.
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PMID:Thyroid function in patients with mycetoma. 749 29


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