Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We wish to stress the importance of remaining alert to the possibility of both depression and suicidality in the geriatric population. There is also a need for flexibility in assessing the elderly who may present with atypical symptoms of depression and who may not express their distress directly. The interaction of risk factors may be instrumental in determining the risk for suicide in a particular patient. In our case, we have identified an impaired ability to communicate, intractable tinnitus, and feelings of helplessness.
 ...
PMID:Suicide in the elderly. Recognizing the signs. 883 59

One hundred and nine tinnitus sufferers attending a specialist out-patient clinic completed questionnaires assessing the following: locus of control of behaviour, anxiety (STAI), depression (BDI) and tinnitus severity. Anxiety and depression were found to be correlated with tinnitus severity, as was locus of control, with "internals" reporting their tinnitus to be less severe than "externals." Partial correlations indicated that locus of control did not directly affect tinnitus severity, but rather, this effect was mediated by the effect of locus of control on anxiety and depression.
 ...
PMID:The relationship between locus of control, tinnitus severity, and emotional distress in a group of tinnitus sufferers. 892 96

Pathophysiological mechanisms are often unknown in patients suffering from "idiopathic" tinnitus, and the presence of other unexplained physical symptoms such as those seen in somatoform disorders can be assumed. This study investigates how often tinnitus exists in general medical out-patients with and without somatoform disorders. In an international study initiated by the World Health Organization (WHO), 1275 patients from 12 participating centers located in 11 different countries were examined by means of the WHO Somatoform Disorders Schedule. The overall prevalence of unexplained tinnitus was 11%; however, tinnitus was clearly more frequent among patients with somatization disorder (42%) or hypochondriacal disorder (27%). It was also more frequent than a great number of other symptoms considered to be typical of somatoform disorders. Tinnitus was also related to depression, anxiety, and to symptoms indicating autonomic arousal. Three possible conclusions are discussed: (i) tinnitus may be a somatoform symptom; (ii) the findings may indicate a substantial comorbidity of two different conditions; (iii) tinnitus and somatization may be linked through common mechanisms of arousal and somatic anxiety.
 ...
PMID:Association between tinnitus and somatoform disorders. 943 74

The present study proposes a validation of a french translation of the TRQ initially published by Wilson et al., for evaluating the psychological distress of tinnitus sufferers. The 26 items translated into french were used on a sample of 173 tinnitus sufferers, who also filled out the Mini-Mult, a short version of the MMPI proposed by Kincannon. Internal validity was demonstrated by strong correlations (i) between each item (except items 5 and 20) and total TRQ score (0.33 < or = r < or = 0.87, p < or = 0.0001), (ii) between each internal TRQ factor (0.58 < r < 0.81, p < 0.0001) and the others. Cronbach's alpha test also showed the questionnaire to have a good internal validity (alpha = 0.94). The external factors used for testing concurrent validity were the scores on depression, psychaesthenia and anxiety Mini-Mult scales. The strong correlations (one factor ANOVA and simple linear regression tests) between scores on depression and psychaesthenia scales and (1) each TRQ item, (2) each TRQ factor, (3) total TRQ scores, confirmed concurrent validity. Scores obtained on anxiety index showed high correlations only with TRQ score, factor 3 score and some TRQ items (most of them included in factor 3). The internal and concurrent validities of the French version of the TRQ justify the use of this questionnaire, with the reserve that items 5 and 20 appeared irrelevant for the measuring of tinnitus distress in French-speaking countries. Such a questionnaire should improve our knowledge of tinnitus' life-impact and enable detection of patients whose psychological distress necessitates rapid intervention.
 ...
PMID:[Validation of French translation of the "Tinnitus Reaction Questionnaire", Wilson et al. 1991]. 948 27

This paper focuses upon the quality of the Dutch translation of the STSS (Subjective Tinnitus Severity Scale), a scale which assesses the severity of tinnitus and the related distress. Research has been done on the psychometric qualities of this scale, its relationship with loudness-matching procedures and several psychological variables. Data presented on 104 tinnitus patients demonstrated the reliability of the STSS with a coefficient alpha of 0.71. Factor analysis revealed four factors: emotional distress, intrusiveness, annoyance and cognitive distress. With regard to the validity, significant correlations of a moderate degree were found with several unitary subjective scales measuring the same construct (rs = 0.50, p < 0.001 and rs = 0.43, p < 0.01). Correlational research demonstrated that the STSS is independent of the loudness of tinnitus as measured by matching procedures (rs = 0.00). In contrast, significant correlations of a moderate magnitude were found with anxiety (rs = 0.33, p < 0.001) and depression (rs = 0.31, and rs = 0.35, p < 0.001).
 ...
PMID:Assessment of distress associated with tinnitus. 962 75

In this pilot study 30 patients with annoying tinnitus completed tinnitus matching and the Beck Depression Inventory (BDI). A cluster analysis revealed three clusters of patients. Cluster one had relatively low depression and average results on tinnitus parameters. Cluster two displayed high depression scores and lower results on tinnitus parameters. The last small cluster had high depression scores and high results on tinnitus and hearing parameters. A curvilinear regression showed a U-shaped relation between the BDI and minimal masking level. The results are interpreted according to a diathesis stress model, in which a vulnerable person might develop tinnitus distress following a comparatively low degree of tinnitus and a more stress-tolerant person might bear higher degrees of tinnitus before seeking help. As a conclusion this may have implications for what treatment to recommend and most certainly should be accounted for in the assessment of patients.
 ...
PMID:Tinnitus masking and depression. 962 62

Tinnitus is an extremely prevalent condition that impinges on the lives of sufferers to varying degrees. In some people, it is a fairly minor irritation but, for many, the tinnitus intrudes to such a degree that it affects their ability to lead a normal life, and in some very extreme cases has resulted in suicide. Insomnia, inability to concentrate and depression are commonly reported to accompany the condition. Relief can be reliably obtained using intravenous lignocaine, which indicates that pharmacology can provide a route for effective alleviation of the condition. In this article, Julie Simpson and Ewart Davies review the potential pharmacological therapies, and emphasize that clinical research has been hampered by the absence of a reliable objective assessment of the tinnitus and by the variable nature of the complaint.
 ...
PMID:Recent advances in the pharmacological treatment of tinnitus. 1010 57

Answers to questionnaires filled out by 436 patients who visited our tinnitus clinic were analyzed. Patients were asked to report the presence or absence of depression and to rate the loudness and severity of their tinnitus. Responses to questions about tinnitus loudness and severity from 121 patients who reported current depression were compared with responses from 285 patients who reported no history of depression. There was no significant difference in reported loudness of tinnitus between patients with and without depression. However, patients with current depression scored significantly higher than patients without depression on all 12 questions relating to tinnitus severity. We conclude that depression and tinnitus severity are linked in some patients. Treatment of depression with medications and psychotherapy is likely to reduce tinnitus severity for many of these patients.
 ...
PMID:Tinnitus severity, loudness, and depression. 1159 97

Although previous research has highlighted the debilitating effects of tinnitus on quality of life, most studies appear to have targeted the general population, with few researchers focusing specifically on elderly persons. Hence, the purpose of this study was to investigate the perceptions of tinnitus in a group of 20 senior citizens. A questionnaire based on existing research instruments developed by Stouffer and Tyler (1990) and Wilson et al. (1991) was used to elicit information regarding the auditory-perceptual characteristics of tinnitus, effects of tinnitus on lifestyle, perceived causes, factors aggravating or ameliorating tinnitus and coping strategies employed. Results supported findings from earlier research and indicated that tinnitus did indeed exert an impact on respondents' lives with 65% avoiding noisy situations, 65% having difficulty relaxing, and 55% struggling to follow conversations. Almost two-thirds, namely 70%, of respondents reported feelings of frustration, 60% and 55% mentioned feelings of tenseness and irritability respectively, while 50% experienced depression associated with the tinnitus. These findings are discussed in terms of their implications for the education of health care professionals, management of tinnitus patients in general, public and patient awareness campaigns, the establishment of Tinnitus Self Help Groups, and further research.
 ...
PMID:Perceptions of tinnitus in a group of senior citizens. 1047 77

Meta-analysis is a technique of combining results from different trials in order to obtain estimates of effects across studies. Meta-analysis has, as yet, rarely been used in audiological research. The aim of this paper was to conduct a meta-analysis on psychological treatment of tinnitus. The outcomes of 18 studies, including a total of 24 samples and up to 700 subjects, were included and coded. Included were studies on cognitive/cognitive-behavioural treatment, relaxation, hypnosis, biofeedback, educational sessions and problem-solving. Effect sizes for perceived tinnitus loudness, annoyance, negative affect (e.g. depression) and sleep problems were calculated for randomized controlled studies, pre-post-treatment design studies and follow-up results. Results showed strong to moderate effects on tinnitus annoyance for controlled studies (d = 0.86), pre-post designs (d = 0.5) and at follow-up (d = 0.48). Results on tinnitus loudness were weaker and disappeared at follow-up. Lower effect sizes were also obtained for measures of negative affect and sleep problems. Exploratory analyses revealed that cognitive-behavioural treatments were more effective on ratings of annoyance in the controlled studies. It is concluded that psychological treatment for tinnitus is effective, but that aspects such as depression and sleep problems may need to be targeted in future studies.
 ...
PMID:A meta-analytic review of psychological treatments for tinnitus. 1050 55


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>