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 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Continuous epidural analgesia consisting of an opioid with or without a local anesthetic agent is a commonly employed technique for pain relief after thoracotomy. In this study, we prospectively evaluated the use of continuous epidural analgesia in 1,324 patients undergoing elective thoracotomy between 1987 and 1993. Epidural pain management was continued for 1 to 3 postoperative days. Patients experienced excellent pain relief, with mean visual analog pain scores of 2.4, 1.7, and 1.4 on postoperative days 1, 2, and 3, respectively. Side effects occurred most frequently in the first 24 hours postoperatively; the incidence of pruritus was 14.1%; nausea, 11.2%; hypotension, 4.3%; sedation, 3.3%; and numbness, 1.1%. Respiratory depression (< 8 breaths per minute) occurred in 1 patient who received 16 mg of supplemental morphine sulfate over a 2-hour period. The incidence of inadequate analgesia (a visual analog pain score of 7 or more persisting for 1 to 2 hours after an epidurally administered bolus) was 3.8%. The results from this study support the use of standard protocols for dosing guidelines, the treatment of inadequate analgesia, and the management of side effects. Daily evaluation by a team member of the postoperative analgesia services section of the Department of Anesthesiology enhances patient care and minimizes adverse effects.
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PMID:Postthoracotomy pain management using continuous epidural analgesia in 1,324 patients. 769 89

A 40-item questionnaire based on reactions following human bereavement was used to investigate the occurrence of grief following death of a pet in a sample of 88 people. Items indicating initial numbness or disbelief, preoccupation with the loss, a loss of part of themselves and being drawn towards reminders were endorsed by half to four-fifths of the sample. About a quarter reported the urge to search, avoidance or mitigation strategies, anger, anxiety and depression. The questionnaire showed high internal reliability, and total scores were significantly positively correlated with the degree of affective attachment to the pet, the suddenness of the death and whether the respondent lived alone; but not with the type of pet, the time since it had died, and how long the owner had been with it. Factor analysis of the questionnaire revealed one main factor accounting for about a third of the variance, described as emotional distress associated with the loss; two lesser factors involved items representing personal importance of the loss and a feeling of continued attachment. Overall these findings indicate a parallel reaction to that following a human bereavement, but with a lower frequency of affective distress. Moderator variables were also comparable with those known to be important for grief following a human loss.
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PMID:Bereavement following death of a pet. 803 9

Residents adjoining a die-casting plant had excessive headaches, numbness of hands and feet, dizziness, blurred vision, staggering, sweating, abnormal heart rhythm, and depression, which led to measurements of neurobehavioral performance, affective status, and the frequency of symptoms. They had all been exposed via well water and proximity to the plant to volatile organic chemicals (VOC) and to polychlorinated biphenyls (PCBs). The 117 exposed women and men and 46 unexposed referents were studied together for simple and choice visual reaction time, body sway speed, blink reflex latency, color discrimination, Culture Fair (a nonverbal nonarithmetic intelligence test), recall of stories, figures, and numbers, cognitive and psychomotor control (slotted pegboard and trail making A and B), long-term memory, profile of mood states (POMS), and scores and frequencies of 34 symptoms. Choice reaction time, sway speed, and blink latency were impaired in both sexes of the exposed group and trail making B was impaired in exposed women. The POMS scores and frequencies of 30 of 34 symptoms were elevated in both sexes, compared to referents. Recall, long-term memory, psychomotor speed, and other cognitive function tests were reduced in exposed subjects and in the referents as compared to national referents. Neurophysiological impairment, and cognitive and psychomotor dysfunction and affective disorders, especially depression and excessive frequency of symptoms, were associated with the use of wells contaminated with VOCs, TCE and PCBs.
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PMID:Neurobehavioral testing of subjects exposed residentially to groundwater contaminated from an aluminum die-casting plant and local referents. 834 33

Patients are presenting in increasing numbers with multiorgan symptoms allegedly resulting from exposure to environmental chemicals. Among the symptoms expressed by patients with alleged multiple chemical sensitivities (MCS) are profound fatigue, mental confusion, myalgia, depression, anxiety, dizziness, headache, insomnia, loss of appetite, and numbness of the extremities, all in the absence of objective physical signs. Diagnostic criteria to assess the effects of environmental agents on organ systems are sorely needed because patients with MCS often have no tissue pathology or physiological abnormalities, but often do have diagnosable psychiatric illnesses. In treating patients with MCS, the physician should first perform a complete history and physical examination, including a comprehensive evaluation of chemical exposure. If the findings strongly suggest the presence of disease related to particular organ systems, further diagnostic evaluation should be undertaken. If abnormal findings are absent, psychiatric advice may be useful. The physician should keep an open mind about MCS but must also remember that a cause-effect relationship between exposure to multiple chemicals and symptoms has not been established.
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PMID:Multiple chemical sensitivity multiorgan dysesthesia, multiple symptom complex, and multiple confusion: problems in diagnosing the patient presenting with unexplained multisystemic symptoms. 895 67

This study assessed pain, neurological symptoms, oedema of the ipsilateral arm, anxiety and depression occurring in women treated surgically for breast cancer, the impact of these symptoms on daily life and how they evolved during the 1 year follow-up. Ninety-three consecutive patients with non-metastasised breast cancer who were treated during 1993-94 were examined before surgery and after 1, 6 and 12 months. They were asked about pain, neurological symptoms and oedema in the breast scar region and/or ipsilateral arm. Sensory testing was performed, and gripping force and the circumference of the arm were measured. Anxiety and depression were evaluated. One year after surgery, 80% of the women had treatment-related symptoms in the breast scar region and virtually all patients had symptoms in the ipsilateral arm. The incidence of chronic post-treatment pain was higher after conservative surgery than after radical surgery (breast area: 33% vs 17%, NS; ipsilateral arm: 23% vs 13%, NS). Numbness occurred in 75% and oedema of the ipsilateral arm in over 30% of the patients after both radical and conservative surgery. Phantom sensations in the breast were reported by 25% of the patients. No difference in psychic morbidity was detected after the two types of surgery. Both the anxiety and depression scores were highest before surgery, decreasing with time, and were significantly correlated with preoperative stressful events.
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PMID:Pain and other symptoms during the first year after radical and conservative surgery for breast cancer. 898 Apr 8

Fifty-eight outpatients with panic disorder (PD) were examined to determine their clinical features in comparison with a cohort of 52 patients with generalised anxiety disorder (GAD). Both groups were of comparable age, sex, educational level, marital status and ethnicity. PD patients were more likely to complain of palpitations, breathlessness, chest pain, numbness, choking sensations and especially fear of dying. GAD patients tended to complain of feeling tense, insomnia, headaches, weakness, restlessness and muscle aches. PD patients had greater comorbidity especially with agoraphobia and depression. Contrary to other reports, there were more males than females in both groups but alcohol dependence and suicide attempts were relatively rare. PD symptoms seemed more distressing, caused more social and occupational disruption, led to more requests for medical investigations and earlier psychiatric consultations. These factors seemed to suggest that panic disorder is a more severe illness than generalised anxiety disorder.
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PMID:Panic disorder in Singapore: clinical features and comparisons with generalised anxiety disorder. 920 72

This descriptive exploratory study examines the behavioral and affective reactions of clients to the suicide of their psychotherapist 1 year after the event, including remembered responses upon first hearing of the suicide. Initial grief reactions of participants were found to be similar to other suicide survivors with strong attachments to the deceased, including depression, numbness, anger, hopelessness, and panic. One year after the event, several participants continued to discuss the event with friends, had persistent feelings of depression and abandonment, and continued to deny the death as a suicide. A reluctance to reenter therapy was also reported. Almost all participants stated that suicide was an acceptable solution to some problems. These results suggest the potential existence of pathological grief for many participants in this study. Implications for the mental health community and intervention services for patient survivors are discussed.
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PMID:Patients' reactions to the suicide of a psychotherapist. 926 Mar

Background: To assess the psychological impact of emergency evacuation on individuals temporarily residing in foreign countries, we surveyed two groups of recently returned Peace Corps Volunteers. Methods: Cases were individuals (n = 265) who had been evacuated under emergency circumstances from their countries of service: Liberia, the Philippines, and Yemen. The control group (n = 90) consisted of the immediate predecessors of cases from the same countries who had completed their service under regular circumstances. Results: There were no significant age or gender differences between cases and controls. The median length of service in the foreign country was 14 months for evacuees and 24 months for regular returnees. Feelings of depression were self-reported by 60% of evacuees while 29% of controls reported this. For feelings of disorientation, 55% of cases versus 33% of regular returnees reported such symptoms. Other symptoms identified by more than 40% of evacuees included: difficulty making decisions (49% versus 26% of controls); anxiety (46% versus 27% of controls); numbness of feelings (43% versus 14% of controls); and periods of crying (43% versus 12% of controls). Conclusion: Temporary residence in a foreign culture may be associated with significant psychological symptoms upon return to one's home country. When forced to depart from one's host country under emergency conditions, the likelihood of individuals reporting these symptoms markedly increases.
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PMID:Psychological and Readjustment Problems Associated with Emergency Evacuation of Peace Corps Volunteers. 981 97

This study examines the course of patient-reported side effects during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-1a (IFN beta-1a), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFN beta-1a by 4 month follow-up.
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PMID:Side effect profile and adherence to in the treatment of multiple sclerosis with interferon beta-1a. 998 57

The purpose of our study was to assess physical and emotional factors in heart transplant patients. A prospective design was used to compare patients' physical symptoms, emotional complaints, and restrictions at admission to the waiting list, immediately after, and 1 and 5 years after heart transplantation. Thirty-three patients were included (30 male, 3 female) in the study. Their mean age at admission was 48 +/- 10.2 years. Of these, 23 suffered from cardiomyopathy, 8 from coronary heart disease, and 2 from valvular insufficiency. At admission, the patients suffered from symptoms of cardiac insufficiency, and were restricted in sports, gardening, hobbies, sexual life, job, food-intake, and mobility. More than three-fourths rated their physical and emotional status as moderate to poor. Emotionally, they suffered from irritability, restlessness, depression, psychic lability, lowered drive, lack of social contact, low self-esteem, and anxiety. At the end of rehabilitation (4-8 weeks after the operation), all physical and emotional complaints, as well as restrictions had significantly decreased (p < 0.0001 to p < 0.001), except for trembling, numbness of hands/feet, and food-intake. One year postoperatively, patients reported even fewer physical complaints (p < 0.01). Three-fourths rated their physical and emotional status good or excellent. Five years postoperatively--in contrast to physical status, restrictions, and physical complaints--the emotional complaints had increased significantly (p < 0.0001). Patients reported excellent physical performance up to 5 years postoperatively. On the other hand, the study revealed that their emotional well-being had significantly deteriorated from 1 to 5 years postoperatively. Attention should, therefore, not only be paid to the good physical health of the survivors, but also to the worsening of their emotional status.
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PMID:Long-term effects of heart transplantation: the gap between physical performance and emotional well-being. 1059 98


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