Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study is to determine the stability of symptoms of hypomania and depression across repeated affective episodes in patients with rapid-cycling bipolar disorder. Nine patients had a total of 30 depressive episodes and 31 hypomanic episodes during the period of observation. Standardized observer ratings indicated that the three symptoms most consistently reported during depressive episodes were fatiguability, decreased work activities and hypersomnia. These results as well as those from the standardized observer ratings of hypomania indicate that depression in this population consists of a lethargic, hypoactive state while hypomania may be a heightened state of activation. The clinical and theoretical implications of these findings are discussed.
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PMID:The reproducibility of depressive and hypomanic symptoms across repeated episodes in patients with rapid-cycling bipolar disorder. 775 65

Seven horses developed clinical or subclinical hepatitis 48 to 87 days after administration of tetanus antitoxin. One horse had mildly high hepatic enzyme activity 120 days after inoculation with tetanus antitoxin. The first horse developed signs of depression, lethargy, and anorexia. During hospitalization, signs of hepatoencephalopathy were noticed, and laboratory data were consistent with hepatic disease. Another horse that was found dead had gross and histologic lesions compatible with serum hepatitis. Screening of serum gamma-glutamyltransferase (GGT) and aspartate transaminase activities were used to investigate the remaining horses in the herd. High GGT activities (71 to 206 IU/L) were detected in 5 additional herd members. These horses appeared clinically normal, apart from 2 reports of nasal photosensitization and an aborted fetus. In 3 horses, high serum GGT activity persisted over a 44-day testing period. All affected horses had been given tetanus antitoxin within 12 hours of parturition, and a common source of vaccine was identified for 7 horses. Findings in this group of horses indicate that clinical and subclinical serum hepatitis can develop after administration of tetanus antitoxin.
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PMID:Hepatic disease associated with administration of tetanus antitoxin in eight horses. 778 47

Self-reported depression and anxiety were examined in 233 inpatient children diagnosed with either an anxiety disorder or a depressive disorder. Depressed children reported more problems related to a loss of interest and low motivation, and they had a more negative view of themselves. Anxious children reported more worry about the future, their well-being, and the reactions of others. The groups did not differ in the degree of depressed affect reported in terms of being sad, lethargic, bothered by things, or feeling alone and isolated. These findings suggest that a general negative affectivity component is common to both anxiety and depression disorders and measures. The results demonstrate that anxiety and depression in children have distinguishing features that can be measured by common self-report instruments, and the findings indicate that 1 factor that may distinguish between anxiety and depression in children is positive affectivity.
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PMID:Anxiety and depression in children and adolescents: negative affectivity and the utility of self-reports. 780 8

Adiposis dolorosa is a disease characterized by painful, subcutaneous fatty tumors. This disorder usually occurs in obese, postmenopausal women and is associated with weakness and mental disturbances such as depression, confusion, lethargy, and dementia. The cause is unknown, and there is no specific treatment. Pain may be relieved by steroids, intravenous lidocaine, or analgesics. Surgical treatment consists of excision or liposuction of the painful masses. We present two cases of adiposis dolorosa in men, with a follow-up of more than 10 years.
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PMID:Adiposis dolorosa (Dercum's disease): 10-year follow-up. 788 63

Two sexually intact female silver-shaded domestic ferret siblings from different litters were examined because of CNS depression and lethargy. Ferret 1 was dehydrated and hypothermic, whereas ferret 2 was icteric and febrile and had serum bilirubin concentration > 12.0 mg/dl and BUN of 59 mg/dl. Despite supportive treatment, the ferrets died within days of evaluation. On necropsy, ferret 1 had chronic hepatopathy, with diffuse vacuolation of hepatocytes. In ferret 2, the liver had centrilobular degeneration and necrosis, and hemoglobinuric nephrosis was evident, with hemoglobin in the renal tubules. In both ferrets, Kupffer's cells and macrophages contained eosinophilic material in the cytoplasm. Special staining revealed copper pigment in hepatocytes and phagocytic cells in both livers. Analysis of liver specimens revealed 850 and 700 ppm of copper in ferrets 1 and 2, respectively. Copper values > 200 ppm in liver are considered evidence of toxicosis in most animal species. Copper toxicosis was diagnosed on the basis of the findings from histologic examination of the liver and high hepatic copper values. Lack of related illness in 11 other ferrets in the same environment and fed the same diet, plus sibling relationship and same phenotypic coat color in the affected ferrets, suggested that these ferrets had an inherited defect in their ability to metabolize normal amounts of ingested copper.
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PMID:Copper toxicosis in sibling ferrets. 789 May 74

A cat with weight loss, pyrexia and recurrent lethargy and depression was found to have pleural and peritoneal eosinophilic effusions, peripheral eosinophilia, eosinophilic lymphadenitis and a massively enlarged mesenteric lymph node. Visceral mast cell neoplasia was diagnosed after histopathological examination of a biopsy of the mass. Palliative chemotherapy was attempted unsuccessfully and the cat was euthanased.
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PMID:Visceral mast cell tumour with eosinophilia and eosinophilic peritoneal and pleural effusions in a cat. 794 1

Elevated cortisol is recognized as a transient response to stress, and is also found among patients with major depressive disorder. Abnormally high levels of thyroxin are associated with nervousness and irritability, while very low levels are associated with lethargy. Therefore it is reasonable to ask if variations in cortisol and thyroxin within a normal population are associated with differences in anxiety and depression. These expectations were tested in a large sample of male army veterans. Nervousness is significantly associated with both thyroxin and cortisol, although several other symptoms of anxiety or depression are not.
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PMID:Do cortisol and thyroxin correlate with nervousness and depression among male army veterans? 794 70

Cytauxzoonosis is a rapidly and highly fatal disease in cats that is caused by the protozoan Cytauxzoon felis, which may be transmitted by Ixodid ticks (Dermacentor variabilis) from parasitemic bobcats (Lynx rufus). During an 8-year period, cytauxzoonosis was diagnosed in 8 cats, 7 cats within 14 months. Risk factors for these cats were warm weather, access to a wooded environment, and exposure to ticks. The most consistent clinical signs were acute lethargy, anorexia, decreased response to external stimuli (depression), icterus, dehydration, and capillary refill time > 2 seconds. Pertinent clinicopathologic findings were normocytic normochromic anemia, leukopenia, and thrombocytopenia; high serum concentrations of total bilirubin and glucose, low serum concentrations of albumin and potassium, high serum alanine transaminase activity; and, bilirubinuria. Confirmation of cytauxzoonosis was made by cytologic or histologic identification of the C felis organism. Splenic, lymph node, and bone marrow aspirates can provide an antemortem diagnosis when the number of parasitized erythrocytes is low on blood smears. Supportive treatment of 6 cats was temporarily palliative in some, but all 8 cats either died (3) or were euthanatized (5) when they became moribund. Survival time from observed onset of illness to death was < 5 days. Necropsy of 4 cats revealed predominately pulmonary involvement with venous congestion. Histologic examination revealed venous occlusion by parasitized mononuclear phagocytes in all tissue specimens, but only minimal inflammatory infiltrates.
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PMID:Cytauxzoonosis in cats: eight cases (1985-1992). 796 Oct 73

In an attempt to study "manic-depressive" affairs associated with endocrine and mental disorders, our clinical data are analyzed before and after appropriate treatment in Cushing's disease, Cushing's syndrome, hyperthyroid Graves' disease and primary hypothyroidism. Although our data do not provide definite findings on manic-depressive affairs associated with Cushing's disease and syndrome, review data by others indicated a high incidence of depression under untreated condition and its disappearance after appropriate treatment. In contrast, patients with adrenocortical insufficiency did have a depression but this was cleared after supplemental therapy. In hyperthyroid Graves' disease, a number of emotional and mental instability and irritability were noticed before the treatment, but these abnormalities all disappeared after appropriate treatment for 3-6 months. In contrast, patients with primary hypothyroidism did show lethargy and apathy, and these abnormalities disappeared after appropriate treatment. From the data accumulated, it is concluded that adrenal steroid and thyroid hormone do affect the functions of nervous system and, as a result, cause a number of clinical symptoms. The exact biochemical processes underlying these abnormalities are not known and remains for further investigations.
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PMID:[Manic-depressive symptom associated with endocrine and metabolic disorders]. 800 7

An 85-year-old man who presented with depression and lethargy was found to have hypercalcemia, normal phosphorous, and low-normal intact parathyroid hormone level. Work-up revealed no evidence of a malignant or inflammatory process. However, 24-hour urinary calcium excretion was increased, 1,25 dihydroxy (OH2) vitamin D3 level was elevated, and angiotensin-converting enzyme (ACE) level was twice normal. The patient responded to a trial of steroids and his 1,25-OH2 vitamin D3 and ACE levels decreased to within normal limits. The patient has remained eucalcemic on low-dose steroids.
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PMID:Hypercalcemia associated with an elevated 1,25 dihydroxy vitamin D3 level and an elevated angiotensin-converting enzyme level in a patient without evidence of sarcoidosis or malignancy. 805 95


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