Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pain and depression are thought to arise from a common neurochemical dysfunction at the level of noradrenergic and serotonergic neurons, and antidepressants are used to treat chronic pain. The dual action tricyclic antidepressants are more potent in relieving pain than the selective serotonin reuptake inhibitors. Glossodynia is chronic pain and burning sensation in the tongue often associated with depression. Patients suffering from glossodynia were treated with the serotonin and noradrenaline reuptake inhibitor, milnacipran, which has been recently launched in Japan. Milnacipran was found to be effective in the relief of the chronic glossodynia and well tolerated.
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PMID:Efficacy of milnacipran for glossodynia patients. 2493 16

Fibromyalgia is a syndrome characterized by chronic pain in the skeletal system accompanied by stiffness, sleep disturbance, fatigue, and psychiatric problems, such as anxiety and depression. Fibromyalgia commonly affects orofacial health, presenting with a variety of oral manifestations, including temporomandibular disorder, xerostomia, glossodynia, and dysgeusia. Therefore, oral healthcare providers need to be aware of this clinical entity to effectively manage oral symptoms and provide proper oral self-care modification and education on the nature of fibromyalgia. This review focuses on the epidemiology, pathophysiology, clinical manifestation, diagnosis, orofacial concerns, and treatment of fibromyalgia.
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PMID:Fibromyalgia: practical considerations for oral health care providers. 3319 4


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