Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three dead dogs were brought to the College of Veterinary Medicine, Kyungpook National University for study. Clinically, all the dogs showed emaciation, anorexia, depression, hemorrhagic vomiting and diarrhea for 7-10 days before death. All the clinical signs were first noted for about one month after feeding the dogs with commercial diets. At necropsy, all 3 dogs had severe renal damage with the same green-yellowish colored nephroliths in the renal pelvis. They also showed systemic hemorrhage and calcification of several organs, which might have been induced by uremia. Microscopically, necrosis, calcification and calculi were detected in the renal tubules, and especially in the proximal convoluted tubules and collecting ducts of the kidney. These findings were supportive of a mycotoxic effect, and especially on their kidneys. However, the precise cause of the toxic effect in these cases of canine renal failure could not be determined.
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PMID:Canine renal failure syndrome in three dogs. 1687 Oct 28

To ensure a healthy elderly population, correction of life-style is one of the most important approaches. Smoking cessation, regulation of alcohol intake, prevention of obesity, improvement of nutrition, promotion of physical activity are key factors for prevention of bed-ridden and extension of healthy life span. Although corrections of life-style are essential in childhood, adolescence, and the middle-aged and elderly periods, the methods and purpose are different in each life stage. The risks of emaciation and malnutrition are more important rather than that of obesity in the elderly aged 75 years or over. As for the influence of smoking in cardiovascular and respiratory diseases, smoking can be a trigger for arrhythmia, peripheral vascular constriction, and irritation of the respiratory tract in the elderly. Smoking cessation is necessary even among elderly people. It is also necessary to decrease the amount of alcohol intake, because the ability of metabolize alcohol is limited in the elderly. Physical activity in the elderly people is fundamental not only to maintain the ability of daily living, but also to improve metabolic function and to prevent depression. Vigorous intervention to increase physical activity such as exercise class is recommended, especially in the elderly.
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PMID:[How far should life-style be corrected in the elderly?]. 1693 34

Homeopathic Crotalus horridus 200C was evaluated in 13 clinical cases of babesiosis in dogs, compared with another 20 clinical cases treated with diminazine. Babesiosis is an important tropical tick-borne haemoprotozoan disease in dogs clinically manifested by anorexia, dehydration, temperature, dullness/depression, diarrhoea/constipation, pale mucosa, hepatomegaly, vomiting/nausea, splenomegaly, distended abdomen/ascites, yellow coloured urine, emaciation/weight loss, and occular discharge. The diagnosis of babesiosis was based on cytological evidence of Babesia gibsoni in freshly prepared blood smears. The dogs were treated with oral C. horridus 200C, 4 pills four times daily for 14 days (n=13) or diminazine aceturate 5 mg/kg single intramuscularly dose (n=20). All the dogs were administered 5% Dextrose normal saline at 60 ml/kg intravenously for 4 days. Initial clinical scores were similar in both groups and showed similar progressive improvement with the two treatments over 14 days. Parasitaemia also improved in both groups, but haematological values showed no change. No untoward reactions were observed. It appears that C. horridus is as effective in causing clinical recovery in moderate cases of canine babesiosis caused by Babesia gibsoni as the standard drug diminazine. Large scale randomized trials are indicated for more conclusive results.
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PMID:Clinical management of babesiosis in dogs with homeopathic Crotalus horridus 200C. 1743 35

A 33-year-old captive male golden eagle (Aquila chrysaetos) was presented for necropsy with a history of emaciation and depression. The liver was severely distorted by numerous, coalescent, poorly demarcated, white firm nodules. Upon microscopic examination, these masses were found to be infiltrative and were composed of anastomosing tubular structures lined by signet-ring cells piling up in a disorderly fashion. Ultrastructurally, neoplastic cells were characterized by abundant microvilli at their apical pole and by numerous junctional complexes on lateral cell membranes. Based on morphological criteria, this tumour was classified as a poorly differentiated cholangiocellular carcinoma. Metastases were found in kidneys, testes, lungs, air sacs, pericardium, pancreas, adrenals and meninges. Additionally, two (11 and 2 mm) beige nodules were found in the cranial portion of the left kidney. Histological examination revealed locally infiltrative compact masses composed of well-differentiated tubules lined by a tall columnar epithelium without microvilli. These tumours were diagnosed as renal tubular adenocarcinomas. This is believed to be the first case of two simultaneous malignancies reported in a bird of prey.
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PMID:Metastatic cholangiocellular carcinoma and renal adenocarcinoma in a golden eagle (Aquila chrysaetos). 1848 7

Ten-day-old cockerels were infected with N. asteroides or N. transvalensis by the oral or intraperitoneal routes. Clinical signs included depression, gasping and emaciation. Grey nodules or foci were observed in the lungs, air sacs, liver and breast muscles. These organs showed necrosis, granulomas, lymphoid follicles and infiltration of lymphocytes, heterophils and macrophages. Intraperitoneal infection resulted in a more severe disease with either organism. N. transvalensis appeared more pathogenic than N. asteroides intraperitoneally and vice versa with the oral route.
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PMID:Experimental infection of chickens with Nocardia asteroides and Nocardia transvalensis. 1867 95

This study was conducted to investigate the corticotropic axis in anorexia nervosa. In 93 female inpatients who met DSM-III-R criteria for anorexia nervosa, subsample (n = 64) with DSM-III criteria was also considered. Using stepwise regression analysis, this study examined the relationship between independent variables ie, age, body mass index, scores on depression scales and postdexamethasone serum cortisol, considered as a dependent variable. In patients who met DSM-III criteria, 16.7% of the variance of serum cortisol can be explained. The main predictors are depressive retardation, emaciation and age. Using stepwise logistic regression the main categorical predictors of the test suppression vs non suppression are of the same nature. The condition of realisation of DST are discussed.
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PMID:Are depression and denutrition good predictors of dexamethasone suppression test (DST) in anorexia nervosa? 1969 57

(1) What appears to be the first case of a chromophobe-cell adenoma of the pituitary gland in an animal is described.(2) The tumour in a maiden bitch, aged 9 years, was associated with depression of the sexual functions for two years, atrophy of the ovaries and vulva, gross adiposity and progressive emaciation.(3) No abnormality was found in the skin and skeleton.
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PMID:Chromophobe cell Adenoma of the Pituitary Gland, associated with Dystrophia Adiposo-genitalis, in a Maiden Bitch. 1998 1

Erysipelothrix rhusiopathiae is pathogenic for humans, many domestic animals and wild birds, but infectious cases with clinical symptoms in cats have not been reported. E. rhusiopathiae was recovered from a 4-month Russian blue breed cat with a very poor body condition score of 1 (BCS: 1/5). The isolate was typed as serotype 2b. Mice experimentally infected with the clinical isolate of E. rhusiopathiae through subcutaneous or intraperitoneal routes survived, and the organism was recovered from the spleen and synovial and pericardial fluids. Cats experimentally inoculated with the isolate either orally or subcutaneously survived but commonly exhibited depression and emaciation together with localized erythemal lesion of the skin accompanied by purulent ocular discharge. On hematological analysis, the number of total white blood cells was high compared with that in normal cats. Histological examination revealed congestion and moderate inflammation with focal necrosis. This observation may provide insight on E. rhusiopathiae infection in cats with the possible epidemiological significance and implications as a potential source of infection to other animals and humans.
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PMID:Characterization and identification of Erysipelothrix rhusiopathiae isolated from an unnatural host, a cat, with a clinical manifestation of depression. 2083 97

Tuberculosis, a List B disease of World Organization for Animal Health, caused by M. avium or M. genavense predominantly affects poultry and pet or captive birds. Clinical manifestations in birds include emaciation, depression and diarrhea along with marked atrophy of breast muscle. Unlike tuberculosis in animals and man, lesions in lungs are rare. Tubercular nodules can be seen in liver, spleen, intestine and bone marrow. Granulomatous lesion without calcification is a prominent feature. The disease is a rarity in organized poultry sector due to improved farm practices, but occurs in zoo aviaries. Molecular techniques like polymerase chain reaction combined with restriction fragment length polymorphism and gene probes aid in rapid identification and characterization of mycobacteria subspecies, and overcome disadvantages of conventional methods which are slow, labour intensive and may at times fail to produce precise results. M. avium subsp. avium with genotype IS901+ and IS1245+ causes infections in animals and human beings too. The bacterium causes sensitivity in cattle to the tuberculin test. The paper discusses in brief the M. avium infection in birds, its importance in a zoonotic perspective, and outlines conventional and novel strategies for its diagnosis, prevention and eradication in domestic/pet birds and humans alike.
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PMID:Tuberculosis in Birds: Insights into the Mycobacterium avium Infections. 2177 52

There have been many cases of burn patients who also suffer from psychiatric problems, including eating disorders. We present a case of a 38-year-old female with an eating disorder and depression who became light-headed and fell, spilling boiling water from a kettle on herself at home sustaining partial thickness and full thickness burns over 5% of her total body surface area: left buttock and right thigh and calf. Eating disorders (in the present case, anorexia nervosa) cause emaciation and malnutrition, and consent for hospitalization from the patient and/or family is often difficult. During the medical treatment of burns for these patients, consideration not only of physical symptoms caused by malnutrition but also the psychiatric issues is required. Therefore, multifaceted and complex care must be given to burn patients with eating disorders.
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PMID:Medical treatment for burn patients with eating disorders: a case report. 2256 40


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