Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-seven symptoms of 859 treated hypertensive patients were evaluated using a self-administered questionnaire and correlated with the depression (DEP), free-floating anxiety (FFA), phobic anxiety (PHO), obsessionality (OBS) and extraversion (HYS) scores of the Middlesex Hospital Questionnaire. The psychological features were associated with 24 of the 27 symptoms, and the extent to which these measurements determined the presence of a symptom was calculated. DEP and FFA were correlated with most of the symptoms, PHO with weak limbs, blurred vision, slow walking pace, nocturia and a lessened interest in sex. HYS was positively associated with the frequency of sexual intercourse in men and negatively with complaints of dyspnoea, tingling in the limbs and a slow walking pace. OBS was only associated with diarrhoea.
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PMID:The contribution of psychological features to the symptoms of treated hypertensive patients. 59 46

23 patients whose weight varied from ninety-eight to 220 kilos were subjected to four different types of jejuno-ileal by pass operations: terminal-lateral (14 X 4) in three, terminal-terminal (14 X 4) in fifteen, (12 X 8) in two, and (10 X 8) in three. The defunctionalized intestine was anastomized to the transverse colon. Liver, jejenum and ileal biopsies as well as profilactic apendectomy were performed in all the cases along with colecistectomy when possible. All our patients were carefully studied in the pre and postoperative periods. The postoperative follow-up varied from 16 to 72 months, during which time a short and long-term mortality of 8.6% was observed. In eight patients it was necessary to reestablish normal intestinal transit for one or two reasons: rapid weight loss or total lack of patient cooperation. During the first few months post-op, diarrhea, nausea, vomiting, loss of apetite, weakness, inactivity, depression, electrolyte anormalities, anemia and increased hepatic esteatosis were the clinical and pathological findings most frequently encountered. With the cooperation of the patient it is possible to correct all these alterations: it is for this reason that the importance of right patient selection is emphasized. The rate of post-operative weight loss varied from patient to patient with an ideal weight being achieved between 18 and 24 months after the operation. Only in those patients reoperated upon to establish normal intestinal transit was the lost weight recuperated. Along with rigid patient selection, the success of this operation depends upon interspecialty teamwork during the preoperative evaluation as well as the follow up period in order to resolve the intricate physio-pathological problems that so frequently arise.
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PMID:[Treatment of extreme obesity]. 61 77

Primary adrenocortical insufficiency is described in 3 dogs. Clinical signs included marked depression, vomiting, diarrhoea, weakness and bradycardia. Diagnosis was based on clinical signs and biochemical findings of hyperkalaemia, hyponatraemia and a lowered plasma Na+ : K+ ratio. Treatment during the acute illness consisted of intravenous fluids and hydrocortisone sodium succinate. Fludrocortisone acetate has maintained all dogs in good health. One dog was on treatment for 4 years.
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PMID:Adrenocortical insufficiency in the dog. 68 64

Sequential chemotherapeutic regimens, primarily used in the treatment of hematopoietic malignancies, and employing ara-C as a basic antineoplastic agent induce mucosal alterations in the entire gastrointestinal tract. These are characterized by surface and glandular epithelial atypia, immaturity, and necrosis. Glandular regeneration is characteristically delayed leading to a state of intestinal aproliferative cytopenia. Other toxic intestinal changes include telangiectasia of blood vessels and the formation of intramural hematomas. Intestinal infections develop frequently and are complicated by peritonitis, liver abscesses, pneumatosis cystoides in testinalis and sepsis. These intestinal lesions are accompanied by a predictable clinical syndrome which begins concomitantly with ara-C infusions and is characterized by diarrhea, ileus, abdominal pain, hematemesis and melena, severe hypokalemia, hypocalcemia and a protein-losing enteropathy. Additional toxic manifestations induced by ara-C include transient weight gains, fever elevations and severe bone marrow depression. The genesis of the intestinal lesions is linked to the three day dose schedule of ara-C infusions which insures both arrest of the cycling intestinal cells in the S-phase and a high cytotoxic index. The severity of these lesions is markedly augmented by prior treatment with ara-C and cyclophosphamide which causes synchronization and probable recruitment of intestinal stem cells, respectively.
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PMID:Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols: a clinical-pathologic study of 33 patients. 70 32

Dibutyltin dilaurate was inadvertently introduced into dairy feed which was consumed by wild palm doves (Streptopelia senegaleniss). About 150 dead and dying doves were found within several days. Extremely high concentrations of tin were found in samples of liver and skeletal muscle in these birds. A sample of the feed, which was found to contain about 2,500 ppm tin, was fed exclusively to 2 normal palm doves. On the 8th day of feeding, one dove died and the other was moribund. High concentrations of tin (27 to 141 ppm) were found in the livers of poisoned birds. Signs of poisoning in both the naturally occurring and experimentally induced poisonings were severe depression and yellow diarrhea.
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PMID:Poisoning of palm doves with dibutyltin dilaurate. 73 43

Weight, Height, head circumference, chest circumference, arm circumference and triceps skinfold of 223 children under 5 years from the small Mentawai island Sipora/Indonesia have been measured and related to international standards. Beginning from standard values, the anthropometric data decrease during the first 2-3 years, rising again in the following years. Weight for age is 72% of standard at 24 months and 83% at 5 years, height for age 89% at 30 months and 92% at 5 years, weight for height of the boys 82% at 12 months, of the girls 79% at 24 months and 94% for both at 4-5 years, chest/head ratio 95% at 12 months and 100% at 3-5 years. Arm circumference is 83% at 18 months 100% and above already at 3 years. Therefore, fold regains after the minimum of 90% at 18 months and above already at 3 years. Therefore, muscle growth would predominantly be reduced. The weight gain follows approximately the 3rd centile of english girls with a clear depression between 9 and 30 months. The birth weights of 476 children are 3230 g (boys) and 3120 g (girls). Perinatal mortality is low (2.9%), mortality during the first 5 years between 15 and 24%. In the health centre charts of 126 children under 5 years of a selected village (93% of that age group) 463 treatments in 5 years are recorded. The most frequent diagnoses are diseases of the respiratory tract (38% of all treatments), followed by malaria (23%), diarrhoea (19%), ascaris and hookworm infections (7.6%) and skin conditions (6%). Tuberculosis was the cause of treatment in 1.3%. In spite of the temporary growth retardation, as indicated by the anthropometric values, no cases of clinical Protein-Energy-Malnutrition have been observed. Malaria seems to be holoendemic, since all 223 children had a palpable spleen.
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PMID:[Nutritional status and health status of under-fives of the Mentawai island Sipora (Indonesia) (author's transl)]. 74 10

Groups of Swiss white mice weighing 25-28 grams were infected orally with 500, 2,000, 5,000 or 20,000 oocysts of Eimeria falciformis var pragensis. Depression, anorexia, weight loss, diarrhea or dysentery, and dehydration were most pronounced at eight to ten days postinfection. The highest mortality, 31%, occurred in mice infected with 20,000 oocysts. None of the mice infected with 500 oocysts died. The pathological findings were equally severe in mice infected with 5,000 and 20,000 oocysts. The enteric lesions, most pronounced at eight to ten days postinfection, were restricted mainly to the large intestine and consisted initially of both cryptal and absorptive epithelial cell destruction and submucosal edema. These changes were followed in 12 to 24 hours by a transient influx of neutrophils into the lamina propria followed by mononuclear cell infiltration which lasted for five to ten days. As the infective dose decreased, the inflammatory response occurred later and was less extensive. When seen, hemorrhage occurred seven to 11 days postinfection. In 50% of the mice infected with 5,000 and 20,000 oocysts, varying degrees of a nonselective mucosal necrosis were seen at eight to 12 days postinfection. In mice infected with 500 oocysts, mucosal destruction was restricted to the epithelium. Neutrophils predominated when necrosis was extensive, otherwise, mononuclear cells were the main inflammatory cells. Two to three days following necrosis, crypt hyperplasia was marked and mucosal integrity was restored. Ulcers, some of which extended into the submucosa, healed by days 14 to 20. Localized granulomatous colitis, induced by trapped oocysts within the lamina propria, was seen until the experiment was terminated at 25 days postinfection. Infection was followed by lymphoid hyperplasia in the lymph nodes and the spleen.
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PMID:The pathological changes caused by Eimeria falciformis var pragensis in mice. 74 2

Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. Controlled studies and clinical experience have shown that it possesses anorectic activity at least as good as that of other therapeutically useful drugs of its type, but like these drugs it has only a limited role in the overall management of obesity. Tolerance to the anorectic effects of fenfluramine may possibly develop more slowly than to other chemically related drugs in patients with refractory obesity. The mechanism of its anorectic action is probably by an effect on the appetite control centres in the hypothalamus, rather than by an effect on glucose and lipid metabolism. However, its effect in enhancing glucose uptake into skeletal muscle may be of advantage in diabetes mellitus, preliminary studies suggesting that it is of potential use in maturity-onset obese diabetics who cannot be adequately controlled by dietary measures alone. The starting dosage in obesity of 40mg daily should be increased gradually over 2 to 4 weeks to 60 to 120mg. In general, little extra benefit is gained by higher dosage. When a course of therapy is to be discontinued, fenfluramine dosage should be reduced gradually over a period of 2 to 4 weeks in order to avoid mood depression which has occurred in some patients on abrupt withdrawal of the drug. With these recommendations, the majority of patients tolerate fenfluramine satisfactorily, although some patients may have to discontinue the drug because of troublesome gastro-intestinal problems, diarrhoea, drowsiness or dizziness. Unlike other amphetamine-derived anorectics, fenfluramine is not a central stimulant in therapeutic doses, and it probably has little abuse potential.
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PMID:Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. 76

Baby pigs orally inoculated with a porcine strain of enterotoxigenic Escherichia coli (K88+,Ent+) showed signs of depression, severe diarrhea, and, in some instances, death. Few, if any, signs of illness occurred if baby pigs were first inoculated with a K88 possessing non-enterotoxin-producing strain of E. coli.
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PMID:Bacterial competition as a means of preventing neonatal diarrhea in pigs. 78 83

Changes in the plasma levels and urinary excretion of zinc have been studied in a series of adult patients receiving intravenous alimentation. Urinary zinc loss may be very high in this group, but serious plasma depletion does not occur unless there is a concomitant phase of sustained anabolism in the absence of significant exogenous intake. A syndrome of acute zinc deficiency is described consisting of diarrhea, mental apathy and depression, a moist eczematoid dermatitis, most severe in the perioral area and alopecia. The response to intravenous zinc therapy is very striking although alopecia is slower to develop and complete hair regrowth is correspondingly delayed.
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PMID:Acute zinc deficency in man during intravenous alimentation. 81 23


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