Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parsalmide- a new drug- is effective in the relief of inflammation and pain. In a double-blind, between-patients, cross-over trial with diazepam in 16 subjects with anxiety and depression, however, it proved less successful in relieving anxiety, though it was on a par with diazepam on an overall evaluation. The daytime somnolence and asthenia observed with diazepam were not observed with parsalmide.
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PMID:[Double-blind comparison of parsalmide and diazepam in anxious and depressive neurotic syndromes]. 1 25

Comparative analysis of functional characteristics of connection between the fields CA3 and CA1 (Schaffer's collaterals) was performed in experiments in vivo (unanaesthetized rabbits) and in vitro (hippocampal slices of guinea-pigs) with extracellular recording of the unitary activity in the field CA1. Weakness of postexcitatory inhibition, absence of responses of the form of suppression of spontaneous activity, higher effectiveness of low-frequency stimulation of Schaffer's collaterals were observed in experiments in vitro. Posttetanic effects were more frequently observed and lasted longer in vitro than in vivo. The dominating effect in vivo was posttetanic depression and in vitro--posttetanic potentiation. The possible reasons for these differences are discussed.
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PMID:[Functional characteristics of connections: Schaffer's collaterals to the CA1 field of the hippocampus in experiments in vivo and in vitro]. 46 Apr 92

This study was an attempt to compare psychological and biological variables in 43 obese patients after intestinal bypass surgery. The difficulties in expressing the psychological variables quantitatively are discussed on the basis of the concept of transferability. By use of an expanded version of the Beck Depression Inventory and the Marke-Nyman Temperament Scale we could demonstrate that items concerning asthenia (self-dislike, irritability, work retardation, insomnia, fatigability, somatic preoccupation about aches and pains, loss of libido, headache, vertigo, palpitations, dryness of the mouth, thirst or increased liquid intake) had, when summed up, a score distribution indicating bimodality. The asthenic group of patients (n = 19) when compared with the non-asthenic patients (n = 24) showed metabolic deficiencies related to the vitamin D complex with no response to oral vitamin D3 administration measured by plasma levels of 25-hydroxyvitamin D3. The lack of response was associated with low calcium excretion in the urine, higher plasma alkaline phosphatase, and a tendency to higher blood levels of parathyroid hormone.
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PMID:Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. 46 85

This study comprises 81 thyrotoxic patients with onset after the age of 60. In elderly persons, toxic multinodular goiter is the most common cause (68%) of hyperthyroidism, followed by solitary thyroid nodules (16%) and Graves' disease (16%). Cardiovascular disorders (cardiac failure, arrythmias etc.) constitute the first and often the only symptom in 62% of the cases. The other forms of appearance are both various and deceptive: depression, slight fever, asthenia or nausea. Separate analysis of the three forms of hyperthyroidism did not reveal clinical, biological or therapeutic differences between them, except an inferior rate of captation for the toxic nodules. Isolated measurement of T3 or T4 is often insufficient to confirm the diagnosis because either of these hormones may appear at a normal rate. In three cases only the free thyroxin index was pathological on first determination. The authors have established that the autonomous nodules are larger and more active after, rather than before, 60 years of age, and have attempted to define their morphological identity. The results of the treatment are analyzed and preference is expressed for radioactive iodine in every form of hyperthyroidism.
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PMID:[Hyperthyroidism in older patients]. 58 12

The paper is concerned with a description of a special form of nervous anorexia related to the presence of vomitophobia. The disease appears on the background of a somatogenic asthenia as a psychogenic reaction and leads to an expressed vomiting reaction. The vomiting reaction becomes fixated with a habitual form of reaction and eventually leads to an emaciation and a development of a special vomitophobic syndrome (vomitophobia proper, voluantary and involuntary vomiting, limitation in food as a measure against vomiting, depression, special ideas of reference).
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PMID:[Atyptical forms of anorexia nervosa]. 85 42

Initial schizophrenia was observed in 15 out of 93 out-patients being treated for cephalea in a Regional Neuropsychiatrical Department. Certain abnormal phenomena in the field of consciousness and body sensations are typical of coenasthetic schizophrenia, with vital asthenia and vegetative symptoms. Cephaleas and head dysaesthesias are reported. There is no doubt that coenaesthetic schizophrenia has many points in common with latent schizophrenia; on the other hand it is also closely linked to hypochondriac depression, the syndrome of endogenous juvenile failure, certain latent depressions, hypochondriac euphoria, vegetative and endoreactive dysthmia and pseudoneurotic schizophrenia. Personal studies of stress responses in schizophrenia, and pneumoencephalographic examinations and EEG data in the active stage suggest diencephalic alteration. For diagnostic and initially therapeutic purposes, every patient with cephalea should be examined thoroughly by the psychiatrist; in this way the number of schizophrenias identified and treated will be considerably increased.
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PMID:[Headache as initial symptom of schizophrenic disease]. 93 51

15 women with premenstrual tension are rated in four symptom groups, anxiety-tension, asthenia-depression, irritability-explosiveness and feelings of swelling. The ratings of anxiety and irritability were also added to a separate group. Ratings were then correlated to plasma oestrogen and progesterone levels and oestrogen/progesterone ratios. There was a significant correlation between oestrogen levels and the anxiety, irritability, anxiety + irritability and depression groups. A correlation was also found between oestrogen/progesterone ratios and anxiety. No significant correlation was found between progesterone levels and symptom ratings.
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PMID:Correlation of symptoms in pre-menstrual tension to oestrogen and progesterone concentrations in blood plasma. A preliminary study. 124 29

A study is presented of 33 patients suffering of borderline neuropsychic disorders of neurotic and affective levels with somatized course. One should distinguish in these patients mental disorders per se (asthenia, depression and hypochondria) and different functional-somatic, vegetative-vascular and senestopathic disorders and their combinations. Somatized disorders characteristic of this age group were singled out: cutaneous-muscular, abdominal, cerebral and cardiovascular. Cutaneous-muscular were most frequent. The problem is discussed of distinguishing peculiar "senestovegetoses" and "senestosomatoses" in the borders of somatized depressive states.
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PMID:[The clinical types of somatization mental disorders in elderly people]. 129 39

Tianeptine is an effective antidepressant with original neurochemical properties. Tianeptine increases the serotonin (5-HT) reuptake after acute and chronic treatment. The efficacy of tianeptine (T) versus placebo (P) was evaluated in the treatment of psychasthenia, because of the role of 5-HT in obsessive-compulsive disorders, the last state of psychasthenia in term of severity. Patients were recruited using the psychasthenia scale; then, their MADRS scores limited those who turned out to the depression. Mean inclusion MADRS scores where 12 (T) and 11.8 (P). Tianeptine is an effective treatment for patients suffering from psychasthenia. Tianeptine is more effective than placebo in global score and in sub-scores (asthenia and somatic symptoms) of the psychasthenia scale. In spite of weak inclusion scores in MADRS, patients taking tianeptine also showed significant improvement, greater than with placebo. The percentage of patients with a reduction equal to or greater than 50% of their MADRS score was significantly more important in tianeptine group. These results could be the illustration of the decrease in associated depressive symptoms or the result of an improvement of symptoms common to MADRS and psychasthenia scales. The same favorable results were obtained in symptoms of anxiety scored by HARS. In term of safety, tianeptine is equivalent to a placebo if we consider somatic complaints expressed by the patients, global improvement evaluated by the patient and the investigator, weight and blood pressure. Interruption of treatment for side-effects concerns the placebo group only (3 versus 0). This excellent safety is particularly well-adapted to the treatment of these out-patients.
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PMID:[Efficacy of tianeptine in the treatment of psychasthenia. A study versus placebo]. 134 Aug 7

A review of the safety and tolerability of fluvoxamine in worldwide marketing studies involving 24,624 patients, predominantly receiving fluvoxamine treatment in uncontrolled studies in depression, has been conducted. There was a marked preponderance of female patients and patients aged between 30 and 50 years. The majority of patients were treated for 6 weeks, with the most frequent modal total daily dose being 100mg. The greatest proportion of adverse experiences occurring, by COSTART body system, affected the digestive system (24.1%), the nervous system (23.7%), and the body as a whole (15.3%). The only adverse experience with an incidence greater than 10% was nausea (15.7%), with somnolence (6.9%) and asthenia (6.2%) as the next most frequent experiences. Notably, the rates of agitation and anxiety were only 1.4 and 1.3%, respectively. The incidences of adverse experiences increased with age, and were slightly higher in females than males. 15.1% of patients discontinued treatment prematurely as a result of adverse experiences, principally nausea, dizziness, vomiting, somnolence, abdominal pain, and headache. The overall incidence of serious adverse events associated with fluvoxamine treatment was 2.5%, and the incidence of overall suicidality, including suicidal ideation, overdose, and intentional overdose as well as attempted and completed acts of suicide, was remarkably low at 0.8%.
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PMID:Review of fluvoxamine safety database. 137 74


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