Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats fed an 18% casein (Cs) or a protein deprived diet (PD) for 8 weeks received injections of Escherichia coli lipopolysaccharides (LPS) in both hind foot pads. While these injections were tolerated in Cs rats, about 50% of PD rats died after 1 or 2 days as a result of a massive necrosis of the liver. To a large extent these lesions were prevented by cortisone. Three days after injection of LPS, Cs rats exhibited a hypertrophy of the popliteal lymph nodes (PLN) and spleen, as well as a drastic increase in DNA synthesis in DNA synthesis in the PLN. Mitotic indices did not increase. The DNA synthetic responses to PLN in the surviving PD rats were much lower than in Cs animals, but a sharp rise in DNA synthesis and mitotic activity occurred in the spleen. The comparison with the effects of LPS in cortisone-treated rats showed that both cortisone-sensitive and -resistant cells participated in PLN activation in rats fed both diets, but that only cortisone-resistant lymphocytes entered mitosis in the spleens of PD rats. LPS also provoked a sharp drop in both DNA synthesis and mitosis in the thymus, probably due to a stress effect, since only cortisone-sensitive thymocytes were involved. In a second experimental series, immunological tests (Rosette-forming cells, Plaque-forming cells, serum hemagglutinin titers) were performed 7 days after intraperitoneal injection of LPS. The responses were not significantly different in Cs and PD rats. This is in contrast with the protein deficiency-induced depression of thymus-dependent humoral immunity.
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PMID:Effects of a protein deprived diet on the hepatotoxicity, and the DNA synthetic, mitogenic, and immunological actions of microbial lipopolysaccharides in the rat. 68 57

16 dental students rinsed daily with a placebo solution, Taurolin 2% (formaldehyde releasing antimicrobial), Vantocil 0.1% (polybiguanide), and with amine fluoride 0.025%. Depression of plaque growth assess with the Sulcular Plaque Index was 50.6, 40.2 and 21.5%, respectively.
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PMID:Inhibition of plaque growth with taurolin, vantocil and amine fluoride. 77 7

The byssus attachment plaque and the tissues responsible for its formation were studied in M. californianus by light microscopy and by transmission and scanning electron microscopy. It was shown that the plaque consists of at least three phases which ultrastructurally resemble three secretions considered to be collagen, mucoid material and polyphenol. The mucoid and polyphenol appear to mix as a colloidal suspension in which the latter is the continuous phase and forms the definitive bonding surface. Plaque collagen represents an extension of thread material into the cementing substance. Stimulated secretion within the ducts and distal depression of the mussel's foot shows a continuum of increasing heterogeneity from the inner toward the outer regions. This reflects the distribution of exocrine cell apices wherein exocytosis of polyphenol granules predominate deeply, mucous granules superficially and collagen granules in between. It is proposed that the morphology of the plaque conforms to theoretical physical-chemical requirements for adhesion under water.
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PMID:The structure and formation of the byssus attachment plaque in Mytilus. 93 73

Gingival health and salivary gland function were evaluated for a period of 5 years in 14 patients who received head and neck irradiation for nasopharyngeal carcinoma (seven patients; total dose greater than 60 Gy, nasopharyngeal field) and Hodgkin's lymphoma (seven patients; total dose less than 50 Gy, "mantle" field). Plaque index (PII), bleeding index (BI), gingival recession (GR), whole saliva flow rate (WSFR), left parotid sialographic morphology, and salivary gland radioisotopic activity were assessed immediately before radiotherapy and annually thereafter. The nasopharyngeal group had perfect correlation between postradiation depression of WSFR and the sialographic and scintigraphic scores (R = -1.00 and -0.96, respectively). The degree of gland dysfunction correlated negatively with BI and the BI/PII ratio (r = -0.497) and with GR (r = 0.681). The same correlations were noted in the group with Hodgkin's lymphoma during the first 3 years of follow-up. However, recovery of parotid gland function (WSFR and scintigraphic scores) and morphology (sialographic scores) and return to the preradiation relation between WSFR and both BI/PII ratio (r = 0.75) and GR (r = -0.71) were noted in the fourth year. The differences between the nasopharyngeal and Hodgkin's lymphoma groups are attributable to the delineation of the radiation field employed in each group.
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PMID:Gingival health and salivary function in head and neck-irradiated patients. A five-year follow-up. 157 3

The prediction of resumption of drinking in posttreatment alcoholics was investigated as a function of five possible confounding variables: depression, anxiety, childhood symptoms of attention deficit and conduct disorders and family history of alcoholism. Male and female detoxified alcoholics (n = 103) in inpatient treatment programs were administered a neuropsychological battery and retested as outpatients 14 months later; peer nonalcoholics (n = 73), given the same battery, had a similar interest interval. Alcoholics who resumed drinking (N = 41) performed significantly poorer on an overall neuropsychological performance index than abstainers (N = 62) who performed significantly poorer than nonalcoholics. Stepwise multiple regression equations using the variables noted above revealed that depressive symptoms, ADD and the performance index were the only variables to enter the prediction (R2 = .26, p less than .001); depression accounted for most of the variance. At retest all three groups improved significantly, but not differentially, and were as significantly different at retest as at initial testing. Implications of these results are discussed.
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PMID:Does neuropsychological test performance predict resumption of drinking in posttreatment alcoholics? 237 90

The present study examined the perceptions of parents of children with attention deficit disorder with hyperactivity (ADD/H) regarding their family environment and depression in comparison with a clinical and a nondisabled control group. Parents of children with ADD/H perceived their family environment as less supportive and more stressful than did either the clinical or the nondisabled controls. Specifically, ADD/H parents viewed their families as having lower levels of interpersonal relationships than did either of the control groups. Ratings of depression for each of the parent groups indicated a greater frequency of depressive symptomatology among the parents of children with ADD/H. In addition, more parents of ADD/H children were separated or divorced. Correlation coefficients computed for the entire sample suggest differences between mothers' and fathers' depression and differences in their perceptions of the family. Recommendations are made for future research as well as the development of treatment programs to incorporate work with the parents of children with ADD/H.
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PMID:Perceived family functioning, marital status, and depression in parents of boys with attention deficit disorder. 280 11

Various reports have indicated that infection of polymorphonuclear leukocytes (PMNL) with influenza virus causes depression of their metabolic and chemotactic responses, but the effect the PMNL has on the life cycle of influenza virus has not been well defined. The studies reported here were undertaken to determine whether influenza virus could replicate within PMNL. Virus-infected and uninfected PMNL were labeled with [35S]methionine and analyzed by gel electrophoresis and fluorography for detection of newly synthesized proteins. Both host- and virus-specific proteins were produced within PMNL. By using indirect immunofluorescence techniques combined with flow cytometry, the expression of newly synthesized viral antigens was detected in virus-infected PMNL. Plaque assays on supernatant fluid from infected PMNL showed that infectious progeny were not produced, indicating that influenza virus infection of PMNL is abortive.
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PMID:Synthesis of viral proteins in polymorphonuclear leukocytes infected with influenza A virus. 304 49

The effects of low-dose single and continuous whole-body irradiation on immune functions were studied in C57BL/6 mice. Plaque-forming cell reaction of the spleen was found to be stimulated by single doses of x rays in the range of 0.025 to 0.075 Gy and by continuous exposure to gamma rays with a cumulative dose of 0.065 Gy. The reactivity of thymocytes to interleukin 1 showed a dose-dependent depression in the dose range of 0.025 to 0.25 Gy, but there was an increase in cell number in the thymus between doses of 0.025 and 0.10 Gy, resulting in enhancement of reaction of the whole organ. Unscheduled DNA synthesis of spleen cells was stimulated by single irradiation with 0.05 Gy and continuous irradiation with a cumulative dose of 0.13 Gy. The implications of these immunologic changes under low-dose radiation are discussed.
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PMID:Radiation hormesis: its expression in the immune system. 355 78

The effects of food restriction or 20 ppm NO2 exposure on humoral immunity were investigated in normal and adrenalectomized C57Bl/6 mice. The thymic and splenic weights of sham-operated mice were similarly diminished after 4 days of NO2 exposure or 4 days of food depletion. The responses of corresponding adrenalectomized mice were less depressed. Undernutrition induced lymphoid organ involution and corticosteroids were partly involved. Plaque-forming cells (PFC) per spleen and per 10(6) cells were markedly depressed after 4 days of NO2 exposure, but less so after food deprivation. The same significant suppression of PFC was observed in adrenalectomized groups. Depression of humoral immunity was independent of stress-induced endogenous steroids. Moreover, NO2 had a specific effect on humoral immunodepression, food restriction being an associated factor.
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PMID:Evidence for humoral immunodepression in NO2-exposed mice: influence of food restriction and stress. 356 84

Jirds with prepatent Dipetalonema viteae infections develop an acquired immunity to challenge infections. The objective of the present study was to observe parasite-specific and nonspecific cellular and humoral immune responses in immune jirds. Splenic hyperplasia was observed in infected jirds during the first 5 weeks of infection. Antigen-reactive spleen cells were observed in the lymphocyte transformation assay at 3 weeks postinfection. A depressed response to concanavalin A (ConA) was seen at 1 week postinfection through week 5. Mitomycin C-treated cells from infected jirds were capable of suppressing the response of normal cells to ConA. Sephadex G-10-nonadherent spleen cells from infected jirds showed elevated responses to D. viteae antigen at 1, 3, and 5 weeks and elevated responses to ConA at 3 and 5 weeks. Filaria-specific antibodies were seen at 1 week postinfection, and titers rose through week 5. Plaque-forming cell production to sheep erythrocytes was not depressed in infected jirds. It was concluded that jirds react immunologically with both cellular and humoral responses during the prepatent period of D. viteae infection. A concurrent immune depression was seen. Its effect on resistance and tolerance remains to be determined.
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PMID:Cellular and humoral immune responses of jirds resistant to Dipetalonema viteae infection. 371 May 84


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