Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phenelzine and imipramine were compared double-blind, in 43 depressed inpatients. A placebo week preceded drug treatment; this allowed early identification of placebo responders who did not therefore enter the study. After three weeks treatment, the two drugs were equally effective on Hamilton, Beck and SCL-90 measures of depression and anxiety. On the the SCL-90 scales of hostility and paranoia imipramine was more effective; in some patients phenelzine was associated with increased hostility. Measurement of MAO inhibition and plasma tricyclic levels indicated that adequate doses were generally used - (mean 81 mg/day phenelzine and 144 mg/day imipramine).
 ...
PMID:A comparison of phenelzine and imipramine in depressed inpatients. 702 42

Psychological testing was done on 20 subjects at various altitudes (sea level, 3,8,10 m, and 5,000 m) during a 35-d mountaineering expedition to Denali (Mt. McKinley). Intellectual functioning and personality changes were studied. While little variation was noted at the lower altitude, at 5,000 m there was a marked deterioration in cognitive ability. This was accompanied by a sharp increase in paranoia and obsessive-compulsiveness and smaller increases in depression and hostility.
 ...
PMID:Psychological testing at high altitudes. 705 27

A case of acute paranoia in a 64-year-old woman with a previous history of one depressive episode is described. Accurate diagnosis was hampered by her illogical and tangential answers to questions and the development of an organic brain syndrome while on neuroleptics and anticholinergics. She did not tolerate tricyclic antidepressants and was unresponsive to three electroconvulsive therapy (ECT) treatments. Because of the previous history of depression and the presence of some depressive symptoms, the possibility of a depression underlying her paranoid psychosis was considered. A dexamethasone suppression test (DST) was performed to confirm this and was found to be abnormal. ECT was then continued with the eventual result of complete remission in symptoms. The authors discuss the potential usefulness of the DST in confirming a diagnosis of depression in selected cases of late onset psychosis.
 ...
PMID:The dexamethasone suppression test as a diagnostic aid in late onset paranoia. 706 13

Social-worker has to follow up important functions within the diagnosis and therapy of a gerontopsychiatric station. His employment also concerns patients with serious psychiatric syndromes as well as depression, paranoia, and dementia. Social-worker completes the function of medical doctor and nurses, has to attend to patient's interests, and gives informations and advice to persons and institutions of environment. Group-therapy belonging patients and other persons to is able to prevent the regressive tendency of psychiatric persons in older age.
 ...
PMID:[Intervention measures in social work in institutional gerontopsychiatry]. 722 18

Although only a very small number of studies have described personality testing in primary anorexia nervosa (patients), they seem to suggest a deeper personality disturbance than commonly suggested by psychiatric interview. These results represent an attempt to define the contribution of psychological test data to differential diagnosis and personality organization in primary anorexia nervosa. Fourteen female schizophrenic and 14 female anorexic patients were compared on the MMPI. No significant differences were found on any of the validity or clinical scales. A product-moment correlation between the two profiles, obtained via a measure of distance between profiles, revealed remarkable similarities in their overall profiles (D2 = .83). The Depression, Psychopathic Deviate, Psychasthenia, Paranoia and Schizophrenia scales occupied the first five rankings for both groups (although in a different order) and were elevated over a T-score of 70 (for the anorexics, the Psychopathic Deviate scale score approached 70). The results are consistent with the few studies that utilized psychodiagnostic tests with anorexics and that point to extremely poor personality integration and to a more serious disorder than a neurotic disturbance.
 ...
PMID:A comparative analysis of primary anorexics and schizophrenics on the MMPI. 730 62

Old people's eating habits are often idiosyncratic and unhealthy; their feeding can reflect such brain disease are dementia, depression, paranoia; poor nutrition can contribute to degenerative brain disease. The modification of nutritional requirements of the aged by genetic factors is discussed.
 ...
PMID:Food selection in the aged. 741 56

Paranoid thinking is a defense mechanism against feelings of inferiority and humiliation. Paranoid behavior serves as a means of getting attention, sympathy and help. A case study of an 81-year-old woman illustrates the nature of geriatric paranoia and the roles of interpersonal relationships, rigid personality, depression, and the impairment of sensory and memory functions. The problem proved to be the effects on the family and neighbors of the patient's verbally expressed paranoid delusions. Treatment consisted of reducing the frequency of these paranoid complaints by means of reality therapy and verbal non-reinforcement.
 ...
PMID:Geriatric paranoia: case report illustrating behavioral management. 743 May 26

In order to assess differences between cocaine dependence alone and cocaine dependence complicated by alcohol abuse, 34 subjects who met DSM-III-R criteria for alcohol abuse and cocaine dependence (COC-ETOH group) were compared with 39 subjects who met criteria for cocaine dependence only (COC-only group) with regard to demographics, substance use, and psychopathology. There were no differences between groups in age, race, employment or socio-economic status. The baseline depression and global severity scores in the COC-ETOH group were significantly higher than in the COC-only group. The COC-ETOH group was significantly more likely to experience a paranoid psychosis with cocaine use and significantly more likely to have abused additional substances in the month prior to study entry. The COC-ETOH group also attended significantly fewer medication management sessions during the 12-week trial. There were no differences between groups in the type or frequency of Axis 1 or Axis II disorders.
 ...
PMID:Features of cocaine dependence with concurrent alcohol abuse. 758 77

In order to determine the effect of family support on the psychological well-being of heterosexual couples with at least one HIV-seropositive, family support data were obtained from couples, who were separately interviewed. Two hundred heterosexuals were interviewed (97 males, 103 females). 182 were partners in HIV serodiscordant couples (18 members were in 10 couples concordant for HIV-seropositivity). Overall, there were 76 HIV+ males and 30 HIV+ females. The Brief Symptom Inventory (BSI) was used to measure psychological distress. Sixty-five per cent of the subjects had family members aware of partners' HIV infection, but only 50% of aware families were reported as supportive. Family support was not a significant predictor of distress. Gender was the most significant predictor of psychological distress as measured by the BSI subscales. Both HIV positive and HIV negative females had more distress than their male counterparts on several dimensions (somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, phobic anxiety and paranoia), and on the General Severity Index (GSI) of the BSI (HIV-positives: p = 0.003; HIV-negatives: p = 0.01). Despite the general lack of association of family support with psychological distress, women in couples affected by HIV had more distress than men. The mental health needs of women clearly differ from men, and continued gender comparisons should be done to develop appropriate and effective interventions for these groups.
 ...
PMID:Gender differences in HIV-related psychological distress in heterosexual couples. 763 82

Thirty-one individuals awaiting trial or sentencing for murder or undergoing an appeal process requested a neurologic examination through legal counsel. We attempted in each instance to obtain EEG, MRI or CT, and neuropsychological testing. Neurologic examination revealed evidence of "frontal" dysfunction in 20 (64.5%). There were symptoms or some other evidence of temporal lobe abnormality in nine (29%). We made a specific neurologic diagnosis in 20 individuals (64.5%), including borderline or full mental retardation (9) and cerebral palsy (2), among others. Neuropsychological testing revealed abnormalities in all subjects tested. There were EEG abnormalities in eight of the 20 subjects tested, consisting mainly of bilateral sharp waves with slowing. There were MRI or CT abnormalities in nine of the 19 subjects tested, consisting primarily of atrophy and white matter changes. Psychiatric diagnoses included paranoid schizophrenia (8), dissociative disorder (4), and depression (9). Virtually all subjects had paranoid ideas and misunderstood social situations. There was a documented history of profound, protracted physical abuse in 26 (83.8%) and of sexual abuse in 10 (32.3%). It is likely that prolonged, severe physical abuse, paranoia, and neurologic brain dysfunction interact to form the matrix of violent behavior.
 ...
PMID:Neurologic abnormalities in murderers. 896 Jul 68


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>