Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty patients meeting specific criteria for atypical depression completed six weeks of double-blind, randomly assigned treatment with phenelzine sulfate, imipramine hydrochloride, or placebo. The overall response rates were 67% with phenelzine, 43% with imipramine, and 29% with placebo. At week 6, phenelzine was superior to placebo on many measures, while the superiority of imipramine to placebo was confined to several variables. Phenelzine was superior to imipramine on the interpersonal sensitivity and paranoia factors of the 90-item Hopkins Symptom Checklist, with trends toward superiority on several other measures, while imipramine was not differentially superior on any measure. Atypical depressive patients with a history of spontaneous panic attacks and hysteroid dysphoric patients both showed extremely low rates of response to placebo and high rates of response to phenelzine. Conversely, those without panic or hysteroid dysphoric features responded equally to all three treatments. Responders to pheneizine also had greater platelet monoamine oxidase inhibition while receiving drug therapy than did nonresponders. Completion of the 120-patient sample will allow more detailed analyses.
 ...
PMID:Phenelzine v imipramine in atypical depression. A preliminary report. 637 21

Specific consequences of cocaine abuse on health and psycho-social functioning were assessed in 55 cocaine-abusing subjects who called a telephone "helpline." REsults showed a high incidence and wide range of adverse consequences including: impairment of job functioning, interpersonal relationships, and financial status; disturbances of mood and cognitive functioning; psychiatric symptoms of depression, paranoia, and increased suicidal/violent tendencies; and physical symptoms of exhaustion, weight loss, sleep problems, and seizures. Cocaine-related automobile accidents, suicide attempts, and violent acts, including a cocaine-related homicide, were also reported. Intranasal users reported no fewer and no less severe adverse consequences than free-base smokers or intravenous users. Our findings challenge popular notions that cocaine is a benign "recreational" drug and that the intranasal route of administration guarantees protection against addictive patterns of use and adverse effects.
 ...
PMID:Adverse effects of cocaine abuse. 643 68

Psychological status was investigated in 46 primary fibrositis (PF) patients, 32 with fibrositis occurring in association with rheumatoid arthritis (RAFIB) and in 76 control patients with rheumatoid arthritis. Groups were similar in tests of life stresses: Family Inventory of Life Events, Multidimensional Health Locus of Control, and self-motivation. Only 28% of PF and 25% of RAFIB had Minnesota Multiphasic Personality Inventory profiles classified as "normal" compared with 51-60% of controls. Both PF and RAFIB had elevated "neurotic" scales (hypochondriasis, depression, hysteria), but only PF patients had statistically significant elevations in the pychopathic deviancy, psychasthenia and paranoia scales. When the Arthritis Impact Measurement Scales were used, PF but not RAFIB patients demonstrated statistically significant elevations on the anxiety and depression scales.
 ...
PMID:Psychological status in primary fibrositis and fibrositis associated with rheumatoid arthritis. 659 58

This study tested whether the symptom dimension subscales derived for the Symptom Checklist-90 (SCL-90) by factor analysis could be replicated in a new sample. It was administered to 442 veterans undergoing psychiatric treatment at a VA psychiatric outpatient clinic. Factor analysis using the principal-components method yielded a factor structure different from those previously reported for other populations. The first factor extracted, Depression, explained 37% of the variance of the entire instrument, or more than eight times the variance explained by the second factor. Only five of the nine reported SCL-90 symptom subscales emerged in this study; the Anxiety and Psychoticism subscales disappeared, and the Paranoia and Interpersonal Sensitivity subscales merged. In this population the instrument seems to measure a single global distress factor instead of nine independent symptom subscales as reported previously. This finding was corroborated by the fact that depressed, anxious, and schizophrenic patients showed no differences in SCL-90 symptom profile shapes, although they did differ in overall symptom intensity.
 ...
PMID:Factor structure and discriminant validity of the SCL-90 in a veteran psychiatric population. 662 Jan 8

Investigated the possible use of the MMPI-168 as a screening instrument for identifying individuals (N = 27) with DSM III diagnosed borderline personality disorder. Using previously reported percentile norms for bright young college graduates as a reference, borderline patients as a group fell above the 98th percentile on the F, Hypochondriasis, Depression, Hysteria, Psychopathic Deviate, Psychasthenia and Schizophrenia scales, as well as the general psychopathology scale (PSY). Additionally, the borderline sample's mean score on the Paranoia scale was above the 95th percentile, and the mean Social Introversion scale was above the 90th percentile. Almost equally distinguishing was the finding that the mean K scale score for the borderline sample fell as low as the 8th percentile for the normative college sample. These results demonstrate that the MMPI-168 response pattern of borderline patients was clearly distinguishable from the great majority of college graduates.
 ...
PMID:Screening for borderline personality disorders with the MMPI-168. 663 May 46

Cluster analysis methods were used to classify Brief Psychiatric Rating Scale profiles for a sample of 88 geropsychiatric patients. Five distinct profile patterns were found to represent adequately most differences in symptom and behavior characteristics of the aged patients. The five phenomenological types are described as agitated dementia, retarded dementia, anxious depression, withdrawn depression, and paranoid psychosis. The appropriateness of this nomenclature is examined with reference to clinical diagnosis, mental status examination, and drug treatment. Prototype profile patterns that can be used to classify future geropsychiatric patients are presented, and a sequence of clinical decisions that should result in similar partitioning of the patient population is discussed.
 ...
PMID:The Brief Psychiatric Rating Scale (BPRS) in geropsychiatric research: II. Representative profile patterns. 669 75

Fourteen morbidly obese women who were candidates for intestinal bypass surgery were compared in terms of psychosocial functioning and dietary behavior to 14 morbidly obese women who elected not to undergo the bypass procedure. Each patient underwent a psychiatric evaluation which included a developmental and dietary history, a mental status exam, and the administration of the MMPI. Diagnoses were based on the DSM-III multi-axial system. There was no difference between the bypass group and the non-bypass group on the Axis I diagnoses, however the bypass group did have a significantly higher frequency of Axis II diagnoses. The bypass group demonstrated significantly higher levels of psychosocial stressors (Axis IV) and lower levels of adaptive functioning (Axis V) when compared to the non-bypass group. The bypass patients also had a significantly higher frequency of past suicide attempts. On the MMPI, the bypass group had significantly higher elevations on scales 2 (depression), 4 (psychopathic deviate), 6 (paranoia), and 0 (social introversion). There were no significant differences between the groups in terms of dietary history and behavior, except that significantly fewer bypass patients could place a numerical estimate on their daily energy intake. These results were discussed in terms of their implications for the assessment and treatment of morbidly obese patients.
 ...
PMID:Psychosocial functioning of two groups of morbidly obese patients. 684 Sep 67

The total sample size for the study of intrapsychic variables was 252 (152 non-drug users and 100 life-time users including 69 current users). Using a multiphasic personality questionnaire, the Eysenck personality inventory and an orientation questionnaire, the authors found that high orientation, extraversion, anxiety and psychopathic deviate scores were associated with a relative risk of drug use. No significant difference is reported between the mean scores of users and non-users on mania, paranoia, depression, schizophrenia, hysteria and neuroticism.
 ...
PMID:Relative risk of adolescent drug abuse: Part II. Intrapsychic variables. 691 3

Although an association of psychiatric symptoms with vitamin B12 deficiency is well accepted, the incidence and nature of these symptoms is not established. To help illuminate the natural history of this illness we review the literature regarding psychopathology associated with B12 deficiency and examine 15 cases, including one of our own, that meet specified criteria for B12-responsive psychosis. In the accepted cases the most common psychiatric symptoms were organic brain syndrome, paranoia, violence, and depression. Several of the patients were not anemic and had no neurologic deficit. Examination of blood smears or obtaining of serum B12 levels should be considered for patients with the symptoms described.
 ...
PMID:B12 deficiency and psychiatric disorders: case report and literature review. 701 36

In the past 15 years, investigators have attempted to relate psychiatric disorders to our developing knowledge about the asymmetrical organization of the cerebral hemispheres. This paper summarizes the varied, limited, and often conflicting results. The authors suggest that progress in this fascinating and potentially fruitful area will be improved by: a) more critical evaluation of the current literature with regard to its contradictions and to the techniques and theories utilized; b) systematic study of carefully diagnosed, large groups of patients; c) concurrent attempts to identify and carefully assess unusual patients; d) control of laterality measures for drug effects, institutionalization, and such cognitive and affective states as anxiety, depression, paranoia, and psychosis; and e) validation of the localizing value of neuropsychological tests in psychiatric patients by the study of previously diagnosed psychiatric patients with acquired focal brain disease.
 ...
PMID:Psychopathology and hemispheric dysfunction: a review. 702 72


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>