Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The authors review the literature describing acute symptomatology produced by the gradual or abrupt withdrawal of heterocyclic antidepressants, monoamine oxidase inhibitors (MAOI) and neuroleptics. 2. Withdrawal of heterocyclic antidepressants and antipsychotic agents causes similar symptomatology. Symptoms produced by the discontinuation of these drugs include nausea, emesis, anorexia, diarrhea, rhinorrhea, diaphoresis, myalgias, paresthesias, anxiety, agitation, restlessness, and insomnia. 3. Psychotic relapse is often presaged by anxiety, agitation, restlessness, and insomnia. Prodromal symptoms are distinguished from the effects of neuroleptic withdrawal by a temporal relationship of the latter to reductions in the dosage or discontinuation of antipsychotic agents. 4. Withdrawal of MAOIs can result in severe anxiety, agitation, pressured speech, sleeplessness or drowsiness, hallucinations, delirium, and paranoid psychosis. 5. MAOI withdrawal phenomena resemble the symptoms produced by the discontinuation of chronically administered psychostimulants. 6. The capacity of MAOIs to exert amphetamine-like effects presynaptically and the propensity of somatic treatments for depression to subsensitize presynaptic receptors regulating the release of catecholamines provide a basis for the development of psychotic symptoms upon the withdrawal of MAOI. Evidence for this hypothesis is reviewed.
 ...
PMID:Heterocyclic antidepressant, monoamine oxidase inhibitor and neuroleptic withdrawal phenomena. 196 71

Five male patients participated in a pilot open-label study of dose-related aspects of response to intracerebroventricular bethanechol in Alzheimer's disease. No patient had remission of symptoms, but three patients improved symptomatically and on tests of memory. Improvement was evident over a restricted range of doses for each subject, and symptoms were worse at doses below and above the optimal range. There was little overlap in the range of doses producing improvement among these three. Two patients had no consistent improvement in memory, and agitation, depression, paranoia, and seizures developed during treatment. Qualitative differences and variability in dosages producing responses complicate the identification of true drug response in the treatment of Alzheimer's disease.
 ...
PMID:Intracerebroventricular bethanechol for Alzheimer's disease. Variable dose-related responses. 197 38

The purpose of this study was to determine whether mentally ill chemical abusers (MICA patients) report greater distress than do psychiatric patients who do not abuse psychoactive substances. Thirty-two MICA patients and 31 non-substance-abusing patients completed the SCL-90-R. Group comparisons indicated that MICA patients reported greater levels of somatization, depression, anxiety, obsessive-compulsiveness, paranoia, and psychotic symptoms. MICA patients also reported greater overall distress than did psychiatric patients without substance abuse problems.
 ...
PMID:Psychiatric symptoms in mentally ill chemical abusers. 199 60

The purpose of this study was to examine to what extent Mexican-American male and female psychiatric patients, who share similar DSM-III--R diagnoses, differ on the MMPI. Differences were found on the Infrequency, Masculinity-Femininity, and Paranoia scales, with the 39 men obtaining significantly higher scores than the 21 women. These results, while suggesting possible differences in the phenomenology of depression, also suggest that MMPI differences between Mexican-American men and women may be reflective of culturally-defined sex roles. These results, when taken within the context of Mexican-American MMPI literature, indicate that researchers should always attempt to account for "gender" when conducting cross-ethnic MMPI comparisons. The practice of grouping the MMPIs of Mexican-American men and women for comparison with other ethnic groups should be discontinued in favor of comparisons that consider the effects of gender and ethnicity.
 ...
PMID:MMPI differences among Mexican-American male and female psychiatric inpatients. 203 57

MMPI profile patterns were compared between combat veteran groups of 168 POW survivors and 67 servicemen who were not war captives in WWII and the Korean Conflict. Results confirm previous reports that the scales, Hypochondriasis (Hs), Depression (D), and Hysteria (Hy), are characteristically elevated among former POWs. Findings also point to the contribution of scales, Psychasthenia (Pt), Paranoia (Pa), and Ego Strength (Es), in differentiating groups, suggesting that negative ruminations, heightened anxiety, interpersonal anger and suspiciousness, and low self-esteem contribute significantly to group differentiation.
 ...
PMID:MMPI profiles of veterans of WWII and Korea: comparisons of former POWs and combat survivors. 203 67

The multifaceted nature of problems foreign students face have led some researchers to conclude that these students tend to suffer from poor health during their overseas sojourn. This assertion is examined among foreign students at the University of Bergen by means of a questionnaire survey. Loneliness, tiredness, sadness and worrying were reported as a frequent source of problem by nearly one in four of over 300 respondents. Students reported a decline in their general state of health as well as a rise in the occurrence of syndrome-like tendencies resembling paranoia, anxiety, depression and somatic complaints. These tendencies were attributed to certain psychosocial factors such as information received regarding study opportunities, social contacts with other tenants in the hall of residence and future job opportunities. Scandinavian students on the whole tended to have better mental health than students from the other countries. The implications of impaired health among foreign students is discussed.
 ...
PMID:Survey of mental health of foreign students. 204 94

In the absence of pathognomonic clinical features, the clinical diagnosis of Alzheimer's disease (AD) remains one of exclusion of other dementias. We investigated the clinical diagnoses among 394 neuropathologically confirmed AD cases in a dementia brain bank. Most patients were correctly diagnosed as AD (348 or 88%). Among the misdiagnosed patients, AD was mistaken for a primary depressive disorder in 14, multi-infarct dementia in 13, Parkinson's disease in nine, and alcoholic dementia in four. The number of misdiagnosed AD patients did not differ between physician specialties but was greater among AD patients with agitation, depression, paranoia, or delusions. This retrospective study suggests that the diagnostic sensitivity for AD is high among a cross-section of practicing physicians and that an important factor in mistaking AD for another illness is unfamiliarity with the potential psychiatric symptoms of AD.
 ...
PMID:Neuropathologically confirmed Alzheimer's disease: clinical diagnoses in 394 cases. 205 48

An analysis from the Finnish East and West Cohort of the Seven Countries Study tested the hypothesis that front line service during modern warfare is associated with depression later in life. World War Two-era Finnish combat veterans were compared to Finnish veterans who were non-combatants. Both groups were followed from 1959 to 1984. Dependent variables were the Zung depression scale and other measures of psychosocial adaptation and mental health. Analysis of variance of Zung scores by combat exposure was close to statistical significance (p = 0.0501). Even if statistical significance had been reached, it is felt that the absolute magnitude of the differences between the populations appear quite trivial. A significant association was found for those who had participated in over nine battles and when grouping depression, sleeplessness, paranoia, hallucinations, schizophrenia, and other mental illness into the general category of any mental illness (O.R. = 4.414; 95% C.I. = 1.113, 17.503). This seems to support the residual stress hypothesis pertaining to modern combat exposure.
 ...
PMID:Depression late after combat: a follow-up of Finnish World War Two veterans from the seven countries east-west cohort. 205 71

A caseload of 86 patients in a geriatric home visiting service was examined to identify the characteristics that determine why certain geriatric patients receive home visits. Only about a third of the patients were physically homebound. The rest left home for at least some medical care and sustenance, and half of those patients went out for everything but mental health care. Among the 29 nonhomebound patients, few were self-referred, and generally the patient's clinician was more concerned than the patient about the continuation of treatment, findings that suggest that the concern of others was a determining factor in provision of home-based care. The most common problems among the nonhomebound elderly in the caseload were paranoia, depression, and physical frailty.
 ...
PMID:Mental health home visits to nonhomebound elderly. 214 25

Fifty-three homeless mentally ill patients were studied by two psychiatrists in a treatment setting in which data could be gathered from family members and other third parties as well. All the patients were severely mentally ill when the homelessness immediately preceding the current admission began. For the study group, the disabling functional deficits of major mental illness appeared to be important contributing factors to homelessness. These deficits included disorganized thinking and actions, poor problem-solving skills, inability to mobilize oneself, depression, and paranoia that prevented acceptance of help. Other important factors contributing to homelessness were the lack of a comprehensive and effective system of mental health care, substance abuse combined with severe mental illness, and the tendency for chronically and severely mentally ill persons, especially during their youth, to pursue their life goals in an unrealistic or irrational way.
 ...
PMID:Factors contributing to homelessness among the chronically and severely mentally ill. 231 76


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>