Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood pressure measurements were recorded in 522 adults and 141 10-19 year-old full and part blood Aborigines in five communities. The means for systolic and diastolic blood pressures at 40 years were close to those reported for Europeans, although below this age, values tended to be lower, and above 40 years tended to be higher than those reported in the Tecumseh study. Hypertension, as defined by the Princeton criteria, was present in 29%, more often in the men (1-6 to 1-0), and eight subjects satisfied the criteria for hypertensive heart disease (HHD). 522 electrocardiograms were recorded on adult subjects at five Aboriginal communities and classified according to categories of the Minnesota code. Of the 210 abnormalities observed, minor T wave inversions and minor S-T segment depression were the most commonly encountered, and were more frequent in female subjects. Q wave changes typical of myocardial infarction was found in 5% of the tracings and occurred mainly in older men. If hypertension and certain ECG codes are assumed to be "risk factors" for the development of clinical ischaemic heart disease (IHD), the urbanized Aboriginal had a higher prevalence compared with Caucasian subjects of the Busselton study. "Probable" and "suspect" ECG changes of IHD, although mainly in the older subjects, were found to be associated with hyperglycaemia, as recognised in Western society. It is postulated that urbanized Aborigines are prone to cardiovascular degenerative disease to a similar or possibly larger extent than Caucasians.
 ...
PMID:Blood pressures and electrocardiographic findings in the South Australian Aborigines. 106 18

Analyses of questionnaire responses from 166 young women on the Cook-Medley Hostility scale of the MMPI, Beck Depression Inventory, and Wahler Physical Symptoms Inventory indicated significant differences between hostile and nonhostile women on depression scores, ranging from mild mood disturbance to borderline clinical depression. Hostile women also endorsed more items which indicated pervasive somatic complaints such as nausea, fatigue, respiratory, gastrointestinal, and cardiovascular distress. These results are discussed in the context of negative emotion and degenerative disease.
 ...
PMID:Concurrent incidence of depression and physical symptoms among hostile young women. 260 30

Three aspects of neuropsychological functioning in patients with ALS are examined. Contrary to previous research, a new psychometric study of psychological adjustment suggested significant depression-distress in this population and related psychological disturbance differentially to signs of upper versus lower motor neuron involvement and to respiratory failure. An association between ALS and impaired neuropsychological functioning is discussed through an examination of the clinical and pathologic literatures. ALS appears to be a multisystem degenerative disease with a variety of expressions that may frequently include loss of cognitive-behavioral competency with progressive involvement of the prefrontal cortex and, in a few instances, profound dementia. Finally, the article describes an analysis of trends in psychological adjustment and in the perception of physical capability over the course of a pilot clinical trial.
 ...
PMID:Neuropsychological perspectives in amyotrophic lateral sclerosis. 310 53

41 patients with a depressive syndrome in middle age (mean age 55 years) were investigated. 19 of them had purely monopolar depressive syndromes without any organic features; 22 patients had a depressive syndrome associated with an organic brain disease (11 vascular, 11 primary degenerative disease). In all patients psychiatric and neurological investigations, a WAIS test, an EEG and a computer tomography were performed. The clinical findings were significantly different in both groups of depression but there was still a considerable overlap of symptoms. The EEG was inconclusive, the psychological test (WAIS) and the computer tomography showed the clearest separation between the organic and the nonorganic depressions leaving only 10% of inconclusive findings. Therefore, it may be concluded that the differential diagnosis of organic or nonorganic depressive syndrome in middle age cannot be made on the basis of one investigation on its own but on the combined results of clinical, functional, and morphological examinations.
 ...
PMID:Depressive syndromes in middle age and organic brain disease. 725 47

We often observe several psychotic symptoms in physical illness-delusions, hallucinations, manic-depressive state and nervous state, for example. The purpose of this chapter is to account for the relationship between manic-depressive state and central nervous disease. Secondary mania is considered to occur in association with physical illness. The criteria for a diagnosis of it is a duration of at least one week, elated or irritable mood, and at least two of the following: hyperactivity, "push of speech", flight of ideas, gradiosity, decreased sleep, distractibility, and lack of judgement. Depressive state is often observed in infarction, infection, neoplasm, head injury and degenerative disease. The differential diagnosis of pseudodementia and pseudodepression are receiving increased attention, we showed the table of clinical characteristics for distinguishing pseudo-depression from pseudodementia.
 ...
PMID:[Central nervous disease and manic state]. 800 6

31 aged inpatients (60-88 years) with major depressive episode (DSM-III-R) have been investigated in order to study the dynamics and reversion of cognitive disorders in late depression and their relation to the course and outcome of depressive phases. The dynamic evaluation was achieved by 4-times testing with HAM-D and MMSE within the phase. All patients had some cognitive disfunction at the crucial of the phase, which in most cases (90.3%) was completely reversible during the therapy. It was found that cognitive disorders were partly associated with depression and where party related to the aging processes. The degree of cognitive impairments at the crucial stage of the phase depended upon the severity (t = 0.73; p < 0.001) and complexity (t = 0.71; p < 0.001) of the depressive syndrome. It also correlated with the duration of active therapy (t = 0.53; p < 0.005) and quality of the following remission (t = 0.48; p < 0.01). The dynamic assessment of the cognitive disorders may be used for the differentiation of pure depression from the states with the beginning degenerative disease, for the prediction of the course and outcome of depression and response to the therapy.
 ...
PMID:[Cognitive disorders in the structure of endogenous depression in old age]. 858 80

Residual Postsurgical Back Pain (RPP) is a complex problem, involving considerable etiologic and diagnostic confusion. About two-thirds of all patients enrolled in chronic pain centers in the United States suffer from RPP. More than 50 billion dollars are spent on the diagnosis and treatment of back pain in this country. In most cases, the etiology of the patient's complaints is multifactorial. Treatment is difficult and frequently involves surgical as well as non-surgical modalities. Surgical treatment is of value in a carefully selected group of patients, either those in whom the original procedure failed to correct the underlying abnormality or those who show evidence of compression of neural elements, or instability of vertebral column. Because extensive co-morbidity is often present, discrete operative intervention may not fully arrest the compete etiology of the patient's distress, and, indeed; may sometimes worsen the patient's complaints. Possible coexisting problems like degenerative disease or depression should be addressed in all patients prior to surgical intervention, so that the corrected variable is the preponderant cause of the patient's difficulty.
 ...
PMID:Residual postsurgical back pain. 862 35

Dementia is characterized by a decline in cognition, behavioral disturbances, and interference with daily functioning and independence. Diagnosis is sometimes delayed as patients or family members often misattribute obvious manifestations of cognitive decline to normal aging rather than to the onset of a degenerative disease. Many physicians do not perform mental status examinations or do not use them effectively to detect early symptoms. Clinical markers are available to decrease the difficulty in distinguishing dementia from depression and confusional states such as delirium. Alzheimer's disease (AD) is the most common form of dementia; others include rapidly progressive dementias, dementias associated with strokes and Parkinson's disease, and frontotemporal dementias. Often, AD coexists with other forms of dementia. Sensitivity to early warning signs, interviews with family members, and mental status examinations are essential to early detection of AD, and will prove useful to primary-care physicians who care for older patients.
 ...
PMID:The initial recognition and diagnosis of dementia. 961 46

Failing memory is a common complaint in the elderly, with the underlying fear of degenerative disease, especially Alzheimer's disease. However, compared with cognitive test results, these subjective complaints are not correlated with any recognizable cognitive disorder. Other factors are involved, including depression or anxiety as well as the social setting, self-esteem and the negative connotation of aging, requiring careful analysis for correct management. Age-related memory impairment is however quite real, expressed by a wide range of symptoms which can be detected on various psychomotor memory tests. The challenge is to detect those patients complaining of failing memory who really have age-related memory impairment and among them those who might be expected to progress to a state of dementia. In clinical practice, the clinician must look for non-cognitive factors (underlying disease state, sensorial disorder, depression, anxiety, social problems) and discuss with the patient his/her degree of independence in everyday activities. For certain patients, psychometric tests, advocated by some authors as capable of detecting pre-dementia states, may be indicated. In general, patients who complain of failing memory, who are not independent for certain everyday instrumental activities (telephone, transportation services, budget, medications) and who do not respond to clues on learning tests may be particularly susceptible to developing Alzheimer's disease.
 ...
PMID:[Memory complaints in the elderly: a step towards dementia?]. 981 94

Dementia is reversible in a minority of patients, and these should be diagnosed but without subjecting the majority with irreversible disease to an excessive set of investigations. Should a battery of ancillary investigations be performed routinely in dementia? Or can these tests be carried out as clinically indicated? Three arguments are important to answer this question. (a) Reversible dementia is rare: about 1% of cases. (b) If the clinical criteria for diagnosing primary degenerative disease are used consistently, the results of investigations can be predicted with sufficient accuracy, except those of blood tests. (c) Treatment of reversible dementia has the best results in its most frequent causes: depression and drug intoxication; however, treatment of medical and surgical causes of dementia may also be effective. Based on these three considerations, we propose the following guideline in the setting of a memory clinic: to perform blood tests in every patient with dementia, but also to perform other tests, such as electroencephalography (EEG) and computed tomography (CT), as clinically indicated.
 ...
PMID:Early diagnosis of dementia: which tests are indicated? What are their costs? 1019


1 2 3 4 Next >>