Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although the FDA recommends imipramine hydrochloride (IMI) only for temporary relief of symptoms of enuresis nocturna (EN), the drug has been applied to a number of other pediatric situations, including the Hyperkinetic Syndrome (HS), childhood depression, somnambulism and pavor nocturnus, school phobia, petit mal epilepsy, allergies, autism, encorpresis and head-banging. We have reviewed the literature, with particular attention to the pharmacokinetics of IMI in children, and its putative mechanisms of action. The drug probably works through a number of different actions, and the futher delineation of these will be of considerable heuristic value. We review the toxic effects of IMI treatment and IMI poisoning in children, and the pediatric literature concerning other antidepressant drugs and lithium carbonate (Li).
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PMID:Imipramine and children: a review and some speculations about the mechanism of drug action. 40 23

A controlled study of siblings of hyperactive boys resulted in the following findings. The hyperactive child syndrome is more common among brothers of hyperactive children than among brothers of controls (26 per cent vs. 9 per cent). Both probands and their brothers presented with more symptoms of depression-anxiety than controls. The probands, but not their sibs, presented with more antisocial symptoms than controls. Although differences in intelligence and achievement scores were found between probands, their sibs, and controls, both intelligence level and academic achievement were within normal limits in all groups.
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PMID:A controlled study of siblings of hyperactive children. 88 9

Monitoring of 5-hydroxyindole (5-HI) levels in blood in hyperactive institutionalized mentally retarded patients before and after drug therapy revealed depression of 5-HI levels in 83% of hyperactive patients. In these patients with low serotonin levels, elevation of 5-HI levels in blood into the normal range by administration of a variety of psychoactive agents was associated with the disappearance of the hyperkinetic syndrome. Patients who remained hyperactive continued to have low 5-HI levels. Return of hyperactivity upon withdrawal of meidication in patients who were previously well controlled was associated with a fall in 5-HI levels. Adverse responses were seen in these patients when they were treated with medications usually tending to lower 5-HI levels in blood. Medications used in the treatment of hyperactivity may be classified as to whether they usually elevate, lower, or have no significant effect on 5-HI levels in blood.
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PMID:Depressed 5-hydroxyindole levels associated with hyperactive and aggressive behavior. Relationship to drug response. 125 23

A primary characteristic of Attention Deficit Hyperactivity Disorder (ADHD) is an inability to establish and maintain sustained attention, which is speculated to reflect frontal lobe involvement. The Knight Verbal Fluency measure was administered to 19 ADHD inpatient boys and to a cohort group of 7 children who were matched for mean age, psychiatric diagnosis (depression), treatment facility, and examiner but were without the diagnosis of ADHD. Analysis indicated that ADHD children performed significantly lower than expected and lower than the similar non-ADHD children. These findings lend support to the hypothesis that frontal lobe dysfunction is involved in attentional process disorders and suggests the potential clinical usefulness in the diagnostic screening of ADHD children of a simply administered measure amenable to interpretation of frontal lobe function.
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PMID:Use of a verbal fluency measure in understanding and evaluating ADHD as an executive function disorder. 148 85

Sixty boys diagnosed as having attention-deficit disorder with hyperactivity were divided into two equal groups, depending on whether or not they were taking medication for their disorder. These two groups were subdivided equally into younger and older groups, the cutoff being 11.5 years. All subjects were given the Children's Depression Inventory, the Coopersmith Self Esteem Inventory and the Children's Attributional Style Questionnaire. Teachers completed the Child Behaviour Checklist and Conners' Teacher Rating Scale. The results indicated that in the older subjects, the medicated group had lower social self-esteem than the nonmedicated group and in younger subjects the medicated group had higher academic self-esteem than the nonmedicated group. There were no significant differences among the groups with respect to depression; all four groups of subjects were mildly depressed. The younger subjects in general were more inattentive, nervous, impulsive and aggressive; and teachers did not report any less externalising behaviour in those subjects who were on medication. These results were interpreted in the light of findings from previous studies, and the lack of drug effect on externalising behaviour is discussed. Clinical recommendations are made for alleviating depression and improving self-concept by means of cognitive therapy, especially for older medicated ADDH children.
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PMID:A comparison of medicated and nonmedicated attention-deficit disordered hyperactive boys. 158 4

Short-term outcomes were evaluated for 65 children who were followed for 2, 4, or 6 months after psychiatric hospitalization. Child (e.g., aggression), parent (e.g., depression), family dysfunction (caretaker inconsistencies), and the modalities of treatment (e.g., point system) are described. Analyses of variance revealed no effects of follow-up interval or length of stay. A regression analysis revealed that low improvement was predicted by child attention deficit disorder with hyperactivity and depressive symptoms, older age, neurological dysfunction, and history of physical abuse. High improvement compared with low improvement children had a more successful adjustment in several critical roles and exhibited fewer individual problem behaviors.
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PMID:Short-term follow-up of child psychiatric hospitalization: clinical description, predictors, and correlates. 164 36

Children and adolescents doing poorly in school or at home or both are often labelled as suffering from attention deficit hyperactivity disorder (ADHD). Frequently the referred child is not examined systematically for the presence of other disorders. This paper presents the diagnostic criteria and management of disorders that may be wrongly identified as ADHD or may coexist with ADHD, thus complicating identification and treatment. The disorders discussed are depression, mania, primary disorder of vigilance, narcolepsy, developmental specific learning disorders, conduct disorders, and acquired neurologic deficits.
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PMID:Attention deficit hyperactivity disorder: the differential diagnosis. 200 14

The present study examined the perceptions of parents of children with attention deficit disorder with hyperactivity (ADD/H) regarding their family environment and depression in comparison with a clinical and a nondisabled control group. Parents of children with ADD/H perceived their family environment as less supportive and more stressful than did either the clinical or the nondisabled controls. Specifically, ADD/H parents viewed their families as having lower levels of interpersonal relationships than did either of the control groups. Ratings of depression for each of the parent groups indicated a greater frequency of depressive symptomatology among the parents of children with ADD/H. In addition, more parents of ADD/H children were separated or divorced. Correlation coefficients computed for the entire sample suggest differences between mothers' and fathers' depression and differences in their perceptions of the family. Recommendations are made for future research as well as the development of treatment programs to incorporate work with the parents of children with ADD/H.
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PMID:Perceived family functioning, marital status, and depression in parents of boys with attention deficit disorder. 280 11

1. Twelve patients with borderline personality disorder and not suffering a major depression were treated with fluoxetine, a selective serotonin reuptake inhibitor, in an open label trial. All of the patients improved, and 75% were rated as much or very much improved. 2. Treatment was generally very well tolerated, but careful dosage titration was important in some patients, especially to manage agitation. 3. Improvement has been maintained with continued treatment throughout the follow-up period which ranged up to six months. 4. Incidental findings suggest fluoxetine may also be of use in treating substance abuse, attention deficit hyperactivity disorder, late luteal phase dysphoria disorder, dysthymic and cyclothymic disorders, and seasonal pattern depression. 5. These preliminary results support the hypothesis that borderline personality disorder may be related to a central serotonergic deficit.
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PMID:Fluoxetine in borderline personality disorder. 281 6

There are few reports in the literature on the agreement between structured interviews and behaviour checklists in terms of specific diagnostic categories. The objective of this paper is to see how this agreement varies by source of information and diagnosis. One hundred children and their parents referred to a mental health clinic were given the Diagnostic Interview for Children and Adolescents (DICA). Parents and teachers also completed a checklist, the Survey Diagnostic Instrument, a modification of the Child Behaviour Checklist. Using likelihood ratios, the parent checklist agreed best with the parent interview, regardless of diagnosis. Among DSM-III diagnoses, the combined disorder anxiety-depression obtained the highest agreement with the DICA, attention deficit disorder with hyperactivity the next, and conduct disorder the lowest. For screening purposes, combining the parent and teacher checklists appears best, while, for diagnostic purposes, using the parent checklist alone may suffice. Nevertheless, positive predictive values remain low and may remain an inherent limitation of any checklist.
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PMID:The agreement between behaviour checklists and structured psychiatric interviews for children. 319 99


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