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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between aggression and depression was evaluated for 528 adults, adolescents and children, who were rated on either the adult or child versions of the Reiss instruments for dual diagnosis (Reiss 1988; Reiss & Valenti-Hein 1990). Criterion levels of depression were evident in about four times as many aggressive as nonaggressive subjects. Anger was significantly associated with both aggression and depression. Although anger may play a mediational role in the correlation between aggression and depression, in this study there was a significant correlation even after the effects of anger were held constant. The findings provide an initial step toward improving diagnostic specificity when evaluating aggressive behaviour in people with mental retardation.
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PMID:Joint occurrence of depression and aggression in children and adults with mental retardation. 833 20

Self-report measures of depression, general psychopathology, and social skills were administered to adolescents ranging from moderate mental retardation to above normal intelligence. Adolescents with mental retardation reported more depression and general psychopathology symptoms. Variance and regression analyses demonstrated distinctions on the basis of mental retardation status for individual measures. Additional analyses identified differences between individuals with above normal intelligence and individuals with mild mental retardation on the basis of depression specifically. Adaptive behavior functioned as a moderator variable, mediating the relationship between depression and intellectual functioning.
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PMID:Adolescent depression: relationships of self-report to intellectual and adaptive functioning. 853 15

A 62-yr-old woman with a history of mental retardation, paranoid psychosis and agitated depression presented with deterioration in her baseline mental status and fever. No obvious source of fever was found on clinical exam or on initial laboratory studies. An 111In-white blood cell (111In-WBC) study was performed 1 wk after hospital admission, which revealed increased uptake in the anterior neck and oral cavity. Subsequent laryngoscopy revealed a red, swollen epiglottis compatible with epiglottitis. While not advocating 111In-WBC scintigraphy as part of the workup of epiglottitis, this case is presented to emphasize the possible milder presentation of epiglottitis in adults compared to children.
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PMID:Clinically unsuspected epiglottitis detected by indium-111-white blood cell scintigraphy. 854 6

In this study we evaluated whether arsonists (n = 98) differ from homicide offenders (n = 55) in regard to psychiatric disorders, suicidality, and criminal responsibility in the context of forensic psychiatric pretrial examinations. Arsonists were mainly male, poorly educated, unemployed, and living in rural areas. Eighty-four percent of the arsonists and 62 percent of the homicide offenders had an alcohol abuse problem. This difference was statistically significant (p = .002). The arsonists more commonly had suicidal thoughts and attempted suicides. Over one-third of the arsonists used fire-setting as a suicide attempt. In comparing the arsonists with the control group, there was a statistically significant difference in the variables that indicate suicidality. Arsonists more commonly had diagnosed psychiatric diseases (p = .008). The incidence of psychoses was fourfold, chronic or severe depression about threefold, and mental retardation twofold when compared with the homicide offenders. Eighty-five percent of the arsonists had received psychiatric care before the crime was committed. The arsonists were more often found to be not criminally responsible for the crime committed (p = .01).
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PMID:The mental state of arsonists as determined by forensic psychiatric examinations. 863 82

Occupying multiple roles has been shown to be a major predictor of psychological well-being. We investigated the effects of multiple roles in the nonnormative case: a sample of aging mothers of adult children with mental retardation. These women have been in the role of caregiver for up to five decades, in addition to occupying the range of roles normatively held in adulthood and old age. We found, using longitudinal analyses, that holding multiple roles in significantly and negatively related to depression in this sample, as in the general population. The effect of multiple roles remains significant even after the previous level of depression is controlled. These results support the role accumulation hypothesis predicting positive consequences of multiple roles on psychological well-being, even in this sample of older women who have had lifelong caregiving responsibilities.
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PMID:The psychological consequences of multiple roles: the nonnormative case. 871 56

We have analyzed products of the serotonin-degradative pathway, in which both N-methylserotonin and bufotenine are formed in urine specimens of products with psychiatric disorders by three-dimensional HPLC with electrochemical detection. Bufotenine was detected in urine from all autistic patients with mental retardation and epilepsy (n = 18) and many autistic patients (32/47) with mental retardation. Bufotenine was detected in the urine of 15 of 18 patients with depression. Thirteen of 15 schizophrenic patients were also positive for bufotenine. N-methylserotonin was also detected in some cases of each disorder. Only two of 200 urine specimens from healthy controls were positive for bufotenine. Thus, the presence and levels of bufotenine might be useful and important markers of some psychiatric disorders.
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PMID:Bufotenine reconsidered as a diagnostic indicator of psychiatric disorders. 874 57

All antiepileptic drugs (AEDs) have the potential for adverse effects on cognition and behavior. Most of the major AEDs, administered in therapeutic doses, cause little or no cognitive or behavioral impairment in group studies. However, individual variability is considerable, and some patients do not tolerate low serum levels, whereas others tolerate high levels without subjective or objective effects. In the past, carbamazepine (CBZ) and valproate (VPA) have been reported to have the fewest adverse cognitive and behavioral effects in children and adults. However, several recent, well-controlled studies have not found significant differences between the effects of phenytoin (PHT) and those of CBZ or VPA. Greater adverse effects have been found for phenobarbital (PB). However, we must use environmentally relevant measures of cognitive and behavioral functioning to measure effects on daily functioning. Future studies must define cognitive and behavioral toxicity in subpopulations (e.g., post-traumatic epilepsy, mental retardation, depression) and with the new AEDs.
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PMID:Cognitive and behavioral effects of antiepileptic drugs. 878 14

A large Swedish family with members affected by progressive external ophthalmoplegia with hypogonadism were followed-up and reviewed. Hypogonadism included delayed sexual maturation, primary amenorrhea, early menopause, and testicular atrophy. Cataracts, cerebellar ataxia, neuropathy, hypoacusia, pes cavus, tremor, parkinsonism, depression, and mental retardation were other features observed in this family. Muscle biopsy samples of advanced cases showed ragged-red fibers, focal cytochrome c oxidase deficiency, and multiple mtDNA deletions by Southern blot analysis. An autosomal dominant mode of inheritance was evident with anticipation in successive generations. Linkage analysis excluded the chromosome 10q23.3-q24.3 region reported as being linked to the disease in a Finnish family with autosomal dominant progressive external ophthalmoplegia. We report for the first time clinical evidence for anticipation in a family with autosomal dominant progressive external ophthalmoplegia. We hypothesize that the nuclear gene causing this enigmatic disorder may be directly influenced by an expansion of an unstable DNA sequence and that the resulting phenotype is caused by a concerted action with multiple deletions of mtDNA.
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PMID:Anticipation of autosomal dominant progressive external ophthalmoplegia with hypogonadism. 894 Dec 70

Depression among 148 Latina women who have children with mental retardation was examined. Results showed that their depressive symptomatology was elevated, with almost half reporting negative experiences in excess of a commonly used cut-off for the Center for Epidemiologic Studies Scale (CES-D). Depression scores related to variables pertaining to the child, mother's health and level of acculturation, and aspects of stress and coping. When mothers were categorized in three groups by CES-D scores, discriminant analysis correctly classified 84% of the low and high group mothers. High CES-D membership was predicted by mothers' reporting more family problems, worse health, fewer interactions with English-speaking persons in their daily lives, and more negative feelings about parenting their child with mental retardation.
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PMID:Depression in Latina mothers of children with mental retardation: a neglected concern. 908 5

This study examined 391 adult referrals made to a mental health clinic serving individuals with mental retardation, in order to explore the relationship between referral source and referral reason. Each referral was categorized into 1 of 8 referral sources (e.g., vocational placements, day treatment programs) and into 1 of more of 10 behavior categories (e.g., depression, externalizing behavior problems). Externalizing behaviors were the most common overall referral reason. However, referral reason did vary as a function of referral source. Also, sex and mental retardation level were associated with referral reason. Implications for assessment practices and future research are considered.
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PMID:Referral reasons for psychological services for adults with mental retardation. 908 29


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