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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The observation that the biogenic amine depleting agent, reserpine, could induce severe depression in a small proportion of the patients treated with it has proved to be seminal finding in what is now a much larger field of research relating the function brain biogenic amine systems to emotions and behavior. A review of the human reserpine literature suggests, however, that factors other than pharmacologically produced alterations in brain biogenic amine metabolism must have been critical determinants of the eventual mood alterations observed in conjunction with reserpine treatment. While some of these factors, such as previous history of depression, ongoing psychosocial and environmental stress, can be intuitively identified, there are practical as well as ethical problems involved in actually testing the relative contribution of these factors in precipitating human depression and thereby determining their importance in a quantitative fashion. In the present paper we have attempted to examine, in a nonhuman primate model of depression, the degree to which factors such as prior rearing condition, repeated peer separation, and housing environment can intact with the behavioral effects produced by biogenic amine depleting agents. Major emphasis will be placed on studies utilizing alpha-methyl-para-tyrosine, an inhibitor of tyrosine hydroxylase, to ostensively reduce levels of the catecholamine neurotransmitters norepinephrine and dopamine. The results of these studies provide quantitative estimates, in terms of dose-effect relationships, of the degree to which a number of factors can combine to produce despair-like behavior in rhesus monkeys. These data may be of practical importance in evaluating the contribution of similar factors to the precipitation of human depression. Analysis of some of the existing literature relating alterations in behavior to changes in biogenic amine metabolism in animals suggests that there are important differences between rodent and primate species. These differences, when fully established, may indicate that additional research examining the mechanisms whereby modest alterations in biogenic amine metabolism can interact with environmental and social stress is needed.
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PMID:Interactions of pharmacological agents which alter biogenic amine metabolism and depression--an analysis of contributing factors within a primate model of depression. 4 83

The present study examined the characteristics and circumstances which distinguished between groups of depressed and non-depressed menopausal women: 20 women were studied overall. The Beck Depression Inventory (BDI) was used to assess depression levels, while the administration and content analysis of a semistructured interview provided information regarding the presence or absence of stress across a number of variables. While the depressed group were not found to differ significantly from the non-depressed group in terms of stress due to physical symptomatology, they did differ on a number of the psychological and social stress variables, and showed a significantly greater combination of stresses compared with the non-depressed group. Some recommendations concerning management are made.
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PMID:Physiological, psychological and situational stresses in depression during the climacteric. 50 71

Suicidal behavior is the result of a combination of factors that span the domains of psychopathology, genetics, early life experience, family interactions, social stress, physical illness, and neurobiology. To develop predictive and explanatory models of suicidal behavior it is necessary to consider all of these domains. A stress-diathesis model is proposed that classifies risk factors for suicidal behavior into those that are trait-dependent and those that are state-dependent. The timing of suicidal behavior is determined by state-dependent factors. The relationship of psychopathologic factors such as severity of depression or anxiety to suicide will be discussed. Biologic changes that correlate with suicide may be either state- or trait-dependent. Particular emphasis will be given to changes in the serotonin system and how these may represent a constitutional risk factor as opposed to a state-dependent risk factor for suicidal behavior.
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PMID:Integration of neurobiology and psychopathology in a unified model of suicidal behavior. 137 33

Fully amygdala kindled rats were exposed to two different inter-male agonistic experiences in order to study the interaction between epilepsy and acute social stress. Victory experience did not influence the severity of seizure behaviour, whereas a single acute defeat modified both ictal and postictal seizure manifestations. Defeat resulted in less severe and shorter lasting motor seizures, and the accompanied postictal inhibition or behavioural depression was of shorter duration in comparison with pre-stress values. The ability of acute defeat to trigger anticonvulsant activity as implied by the weakened convulsive response is discussed.
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PMID:Effect of different agonistic experiences on behavioural seizures in fully amygdala kindled rats. 150 89

This community-based epidemiological survey is concerned with relationships between social and environmental factors and dysthymic disorder (long-lasting depression according to the DSM-III classification) in a Finnish population aged 60 years or over. A greater proportion of dysthymic than non-depressed men had retired and did not work at all. The occurrence of dysthymic disorders in both men and women was related to retirement because of sickness rather than age, a small number of rooms in their homes, lack of intimate friendships and the occurrence of many long-standing and current social stress factors. The dysthymic women had lived at their present place of residence for a shorter period than had the non-depressed women. A positive association of dysthymic disorders with moving house due to poor health and living in institutions was also found in the men, and with a low number of hobbies and poor social participation in the women. In addition, the dysthymic women felt their relationships with their spouse, children, daughters-in-law and friends to be more distant than did their non-depressed counterparts. The dysthymic women also felt that elderly people were not appreciated. The log-linear models showed three interactions for the dysthymic men and six for the dysthymic women. The dysthymic persons reported a significantly larger number of detrimental events of an interpersonal nature than did the non-depressed persons.
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PMID:Social and environmental factors and dysthymic disorder in old age. 161 57

Long experience of defeat in daily social intermale confrontations and permanent living with aggressive males under sensory contact conditions [Kudryavtseva (8)] has been shown to produce changes in the patterns of submissive behavior of male mice of C57BL/6J strain. The submissive males after 20 defeats demonstrated passive defense postures instead of active defense and withdrawal which they had displayed in first encounters. Moreover, new immobile postures appeared, which were very rare in the first confrontations. Submissive animals displayed a decrease of ambulation in the open-field test and increase the immobility time in the Porsolt's test. Chronic treatment with imipramine prevented the increase of "depressiveness" estimated by means of the Porsolt's test. There was a loss of weight and some disturbances in gastrointestinal functions. The data are discussed in terms of the development of depression in submissive male C57BL/6J mice as a result of chronic unavoidable social stress.
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PMID:Social model of depression in mice of C57BL/6J strain. 205 1

Recent work demonstrates that hearing impairment is much more common than previously suspected. The disability may be unrecognized or denied by the sufferer and may attract social stigma rather than sympathy from others. The effect on mental health is surprisingly neglected. Early studies of psychiatric patients suggested hearing impairment is an important cause of paranoid illness, but more recent studies of wider populations have failed to confirm this association. Hearing impairment is unrelated to intellect when controlled for age, but is an important differential diagnosis of dementia in the elderly. Evidence accumulates to suggest that the hearing impaired are vulnerable to depression, social stress and isolation, but reliable controlled studies of psychiatric sequelae are needed.
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PMID:Mental health and acquired hearing impairment: a review. 218 May 15

Thirty-three patients admitted to hospital with severe early onset puerperal psychiatric disorders were compared with matched normal puerperal controls. Interviews, which were administered after recovery, covered life events in the previous thirteen months and detailed assessment of previous and personal history, pregnancy and labour, other aspects of stress, social support, and marital relationships. No differences, except for previous history of psychiatric disorder, were found between patients and controls or between patients with depressive and with other diagnoses. These findings of absence of social stress contrast with previous studies of milder post-partum depression and of disorders with onset during pregnancy, and suggest that the aetiology of severe post-partum disorders is predominantly biological.
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PMID:Life events and social stress in puerperal psychoses: absence of effect. 223 75

Previous reviews of psychological factors in arthritis have emphasised the methodological weaknesses of many studies, especially those attempting to measure personality after years of disabling disease. To make sense of the published reports three factors need to be considered separately: previous personality, social stresses, and current mental state. Each can now be measured reliably and independently of symptoms which might be directly attributable to the arthritis. There is a growing consensus that the normal range of personality is represented among patients with early arthritis, that the prevalence of depression is similar to that of patients with other medical conditions, and that social stress is more closely related to depression than activity and the disabling effect of arthritis. Longitudinal studies are now required to examine which social stresses can be attributed to the disabling effect of arthritis. Depression and social stress often manifest themselves to the rheumatologist as excessive complaints of pain and frequent clinic attendances so appropriate psychosocial treatments may reduce this behaviour.
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PMID:Psychological disorders in rheumatoid arthritis: a growing consensus? 224 Dec 74

This community-based epidemiological survey is concerned with relationships between social and environmental factors and atypical depression in a Finnish population aged 60 years or over. The occurrence of atypical depression was related to older age, widowed or divorced marital status, having moved during the previous few years, living in a small dwelling near the local population center, having neighbors living in the same building, living alone, being frequently alone, a low number of hobbies and many long-standing or current social stress factors. In addition, the atypical depressive persons felt that elderly people were not appreciated. The log-linear model constructed for atypical depressive persons revealed five subgroups. The first was characterized by living alone and being widowed or divorced, the second by living alone and having a low number of hobbies and a high incidence of long-standing social stress factors, the third by being frequently alone and being widowed or divorced, the fourth by a low number of hobbies and a low incidence of actual social stress factors, and the fifth by living alone and having a high incidence of long-standing social stress factors and a low incidence of actual social stress factors.
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PMID:Social and environmental factors and atypical depression in old age. 232 46


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