Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An epidemiological study was conducted to assess the mental health problems of first year male students studying in two educational institutions. Based on the findings of general health questionnaire and hospital anxiety and depression scale, the estimated prevalence of psychological disturbance was found to be 33% for the whole sample. Present findings are discussed in terms of early identification and provision of better health facilities for the students population.
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PMID:Psychiatric morbidity among male students. 807 28

This study investigated the factors affecting recovery from low back injury. The study population was designed to be representative of patients presenting with back pain following soft tissue injury. A minimum follow up rate of 90 percent was achieved with a length of elapsed time from the injury of up to five years. Three established methods of assessment of disability and functional capacity (The Oswestry disability scale, The Waddell disability scale and The Waddell physical impairment rating) were compared to each other and a new scale (The Low-Back Outcome Scale) for the measurement of a patient's performance in employment, social activities and activities of daily living. The relationships of these scales to employment, psychological disturbance and other factors were defined. The Outcome Score designed for use in this study provided a comprehensive and discriminating assessment of patient function. Compensation (particularly lump sum claims), psychological disturbance at review, time off work, and age at injury were important factors in recovery; the diagnosis, type and severity of injury, migrant status and neurological deficits were not. Eight psychometric instruments were examined, and the combination of The Zung Depression Scale and The Modified Somatic Perception Questionnaire was found to be the most accurate in determining the presence of psychological disturbance in patients with low back pain.
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PMID:Recovery from low back pain. 1-5 year follow-up of 287 injury-related cases. 821 39

Using four different psychological tests, namely Spielberger's rating scale [The State-Trait Anxiety Inventory (STAI)], Self-Rating Depression Scale (SDS), Maudsley Personality Inventory (MPI) and Baum test, we investigated the perioperative psychological status of patients undergoing radical mastectomy for breast cancer and compared data with those of patients undergoing total hysterectomy for uterine myoma. Parameters reflecting the psychological status of hysterectomy patients disclosed lower postoperative anxiety, and slight nervousness and persistent depression perioperatively. In contrast, in patients with breast cancer, those with nervousness had persistent anxiety and depression, while those without nervousness showed the same persistent depression as in hysterectomy patients, as well as a high anxiety level postoperatively. Therefore, we speculate that the persistence of depressive mood during the perioperative period is a factor in the psychological disturbance of mastectomy patients with breast cancer, and moreover, they appear markedly apprehensive because of cancer. These results suggest that the persistence of anxiety and depressive mood associated with cancer is a prime factor in the etiology of postoperative psychological disturbance.
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PMID:[Perioperative psychological status of patients undergoing radical mastectomy and total hysterectomy]. 831 93

This study aimed to assess the psychological impact of screening for cystic fibrosis (CF) carrier status in a population of pregnant women. A cohort of 1798 women, who accepted the offer of testing before 18 weeks of pregnancy, filled in a self administered questionnaire seeking information on their perceived risk of carrier status and their emotional response, as well as a general health questionnaire (GHQ). Sixty-four women identified as CF carriers had partners who received a negative test result. This group and their partners were assessed, together with selected controls, on four further occasions: (1) on receiving the carrier's positive test result; (2) on receiving the partner's negative test result; (3) six weeks later; (4) six weeks after delivery. The instruments used were the GHQ and the Symptom Rating Test (SRT). When compared to control subjects, carriers showed a significant increase in generalised psychological disturbance which could be attributed specifically to symptoms of anxiety and depression during the period (average four days) that they awaited their partner's test result. On receiving a partner's negative test result, the carriers returned to control levels and maintained this equilibrium. Although there was no significant difference in generalised psychological disturbance between partners and their selected controls, partners did become significantly more anxious and manifested feelings of inadequacy while awaiting their own test result. Both male partners and male control subjects were more likely to become anxious if their partner was distressed.
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PMID:Prenatal screening for cystic fibrosis: psychological effects on carriers and their partners. 841 Oct 25

Domestic violence is a widespread problem in our society that has not been extensively studied using psychological assessment tools. In this investigation, the psychological functioning of battered women in transition was examined through the use of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Thirty-one women (M age = 30 years, M education = 11.5 years) were evaluated as residents in a confidential shelter operated by Women Against Abuse. All subjects were asked to complete the MMPI-2 as well as information on their history of length, severity, and types of abuse (i.e., physical and/or psychological). Results indicated elevated MMPI-2 profiles in 90% of the subjects with the most frequent code type being a combination of Scales F, 4, 6, and 8. Scales 2 and 7, which are often associated with depression, anxiety, and other forms of subjective distress, were not consistently elevated. Supplementary MMPI-2 scales revealed elevations on scales MAC-R, Mt, PK, and PS. Regression analysis indicated significant relationships between length and severity of psychological forms of abuse and overall levels of psychological distress (i.e., F scale and average clinical T-score). Age and physical forms of abuse were not related to MMPI indices of psychological disturbance. Theoretical issues of domestic violence, intervention strategies with battered women, and the dangers of misdiagnosis are discussed.
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PMID:MMPI-2 profiles of battered women in transition. 843 60

The theoretical influence of self-concept on cognitive and emotional aspects of behaviour was tested in an exploratory survey of 187 Australian and Vietnamese student nurse participants. Symptoms of depression were depicted in either a family scenario or a context-free list and were rated for perceived depression utilizing the Hopkins Symptom Checklist-25 (HSCL-25). Narrative data were also obtained. Australians perceived significantly more depression than the Vietnamese who normalized the behaviours. There was a significant interaction between culture and the context of depression, whereby the Vietnamese, in contrast with the Australians, perceived greater depression in the family scenario than in the list. Thematic analysis of narrative data assisted interpretation by revealing Vietnamese themes of family and disruption of social harmony, philosophical and temporal approach to life and judgementalism. Australians were more focused on individual concerns such as psychological disturbance and the need for independence. Implications for transcultural nursing were drawn.
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PMID:Culture and the self: implications for the perception of depression by Australian and Vietnamese nursing students. 879 62

Non-compliance with therapy is a significant problem, particularly when the disease process is chronic and therapeutic regimens are employed for prolonged periods. We assessed the prevalence and variables associated with compliance with antiretroviral therapy in patients with human immunodeficiency virus infection, by means of a longitudinal observational study of 46 patients aged 23 to 68 years, with human immunodeficiency virus infection, followed at the Pittsburgh VA Medical Center. Data on demographics, medical status, physical functioning (Karnofsky performance scores), CD4 lymphocyte count, depression (Beck depression inventory), coping (inventory of coping with illness scale scores), and psychological and emotional stress (profile of mood states scale scores), were prospectively assessed on all patients at baseline and every 6 months. Compliance was assessed at 6 and 12 months: patients taking > or = 80% of antiretroviral therapy were considered compliant. Overall, 63% of patients were compliant with antiretroviral therapy. Age, education, employment, religious support, and perceived quality of life did not correlate with compliance. By univariate analysis, lack of prior intravenous drug use was significantly associated with compliance (p = 0.01). Compliant patients had significantly better adaptive coping (p = 0.03), and less depression (p = 0.04). By multivariate analysis, black race was significantly associated with non-compliance independent of intravenous drug use and educational status. History of prior opportunistic infection (which presumably heightens the perceived severity of illness) (p = 0.02), and lesser psychological disturbance scores (p = 0.02) were associated with compliance. Compliance was observed despite the greater number of prescription medications taken by compliant patients (p = 0.04). At 12 months, Karnofsky scores were better in compliant patients (p = 0.02), although mortality was not different. Besides identifying predictors of compliance, our data suggest that symptoms of depression and psychological stress be sought in patients with non-adherence.
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PMID:Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance. 882 19

The occurrence of a sports-related adjustment disorder can inhibit optimum athletic performance and scholastic achievement and impair the overall functioning of athletes. Physicians and trainers caring for athletic teams must maintain an acute awareness of the athlete's mental and physical well-being to detect subtle signs of a mood or psychological disturbance. The case of the collegiate basketball player discussed here exemplifies the subtle presentation and stages of an adjustment disorder with the predominant manifestation of depression mixed with anxiety and disordered conduct. This player's lack of participation in practice and game play led to a distorted view of his self-worth, which slowly eroded his ability to play basketball, attend classes, and enjoy previously pleasurable activities.
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PMID:Recognition of adjustment disorder in college athletes: a case study. 892 69

Concern about the safety of silicone breast implants has led many women with numerous physical and psychological symptoms to seek breast implant removal. This retrospective group comparison study describes the psychological profile of women requesting breast implant removal compared with two control groups. The Brief Symptom Inventory was used to compare psychological symptoms of three groups of women: a preoperative breast implant group requesting removal of implants (n = 78), a postoperative breast cancer group without breast implants (n = 64), and a control group with no known breast disease and unknown breast implant status (n = 68). Scores were compared on the Global Severity Index of the Brief Symptom Inventory as well as on nine subscales: somatization, obsessive-compulsiveness, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. The breast implant group had significantly elevated Global Severity Index scores, as well as somatization, obsessive-compulsiveness, depression, hostility, and anxiety subscale scores, when compared with the other groups. Post hoc data analysis revealed that women who had implants after subcutaneous mastectomy as prophylaxis for breast cancer (n = 18) had a significantly different symptom profile and higher Global Severity Index scores than women who had cosmetic augmentation (n = 53). Additionally, women who had subcutaneous mastectomy and implants had significantly higher subscales of interpersonal sensitivity, phobic anxiety, paranoid ideation, and psychoticism than the cosmetic implant subjects. Women requesting removal of silicone breast implants had greater psychological distress than women who were recently diagnosed with breast cancer or controls with no known breast disease and unknown implant status. Within the implant group, however, women who had subcutaneous mastectomy showed greater psychological disturbance than those who had augmentation mammaplasty.
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PMID:Comparison of psychological symptoms of women requesting removal of breast implants with those of breast cancer patients and healthy controls. 904 86

The MMPI performance of two sub-groups of chronic insomniac patients was compared to determine if patients with psychologically based insomnia (Group 1) differed from those with medically based insomnia (Group 2). This was done to establish whether etiology of insomnia had an impact on the psychological picture. We postulated that Group 1 would show a higher overall incidence of psychopathology, particularly on scales suggesting internalization of distress. Surprisingly, the results revealed no significant differences between the groups with respect to these questions. When the two diagnostic groups were combined, the sample as a whole was characterized by a high overall prevalence of psychopathology. As many as 79.3% of the MMPI records contained one or more clinical scales in the pathological range. Depression was a prominent feature. Our findings emphasize the importance of not assuming that a patient with an organically-based insomnia (e.g. due to sleep apnea, etc.) is free of psychological disturbance. This, in turn, underscores the need for a psychological evaluation as a routine part of the diagnostic work-up of all insomniac patients, regardless of the etiology of their disorder.
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PMID:Comparison of MMPI profiles in medically and psychologically based insomnias. 917 76


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