Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was carried out to assess whether psychiatric morbidity after a miscarriage is higher than that associated with early pregnancy. A total of 60 consecutive women admitted to a Swansea hospital with a miscarriage were compared with 62 consecutive women who attended an antenatal clinic at the same hospital, using the 28-item general health questionnaire and the hospital anxiety and depression scale. These were completed both at initial contact and six weeks later. Women who had had a miscarriage were found to be significantly more anxious and scored higher on the subscale for severe depression than the pregnant women, both at initial assessment and six weeks later. At the six week assessment more somatic symptoms were also experienced by the group who had had a miscarriage. This study highlights the psychological disturbance associated with miscarriage. The primary health care team and hospital staff need to take this into consideration when organizing follow up for women who have had a miscarriage.
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PMID:Psychological sequelae of miscarriage: a controlled study using the general health questionnaire and the hospital anxiety and depression scale. 149 42

To study the relation between specific coping-response preferences and three dimensions of psychological disturbance in adolescents, 41 adolescents who had been admitted to an inpatient psychiatry program completed measures of depression, social maladjustment, suicidality, and coping responses to stressful life events. Analysis indicated that lower affective regulation was associated with increased depression, higher emotional discharge was associated with increased social maladjustment, and lower problem solving was associated with suicide attempts.
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PMID:Coping responses in depressed, socially maladjusted, and suicidal adolescents. 152 81

In order to study the changes of the psychological status during perioperative period, we performed four different psychological tests, Spielberger's rating scale "The State-Trait Anxiety Inventory (STAI)", Self-rating Depression Scale (SDS), Maudsley Personality Inventory (MPI) and Baum test, in 63 patients who received simple total hysterectomy for myoma of uterus. The anxiety ratings showed a significant decrease postoperatively. On the contrary, the SDS index that expresses the level of depressive mood showed no significant change during perioperative period. Moreover the patients who had shown a tendency of nervousness in MPI kept the high level of the SDS index during perioperative period than the other patients who had not shown a tendency of nervousness in MPI. In Baum test, more than 75% of patients manifested psychologic fragility or lability. These results suggest that depressive mood affects strictly the psychological status in postoperative period more than anxiety. We presume that the depressive mood during perioperative period is responsible for the postoperative psychological disturbance.
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PMID:[A study on the psychological status of perioperative patients (II)]. 155 60

At the Oxford Haemophilia Centre at Churchill Hospital in Oxford, England, psychiatrists compared data on 37 HIV seropositive hemophiliacs (31 asymptomatics and 6 symptomatics) with data on 36 HIV seronegative hemophiliacs to determine the prevalence of psychosocial conditions in HIV seropositive men and factors related to those conditions. HIV seropositive men had much higher Present State Examination scores than did the HIV seronegative men (5.9 vs. 2.2; p=.005). This was true for both symptomatic and asymptomatic HIV seropositive men (7.3 and 5.7, respectively). Nevertheless, these levels of psychological disturbance were basically the same as the general outpatient medical population as was also the case with depression scores (POMS). Still symptomatic HIV seropositive men were more likely to be depressed than HIV seronegative men (6.4 vs. 3.6; p=.02). The most important finding was that both symptomatic and asymptomatic HIV seropositive men felt significantly higher levels of hopelessness than did the HIV seronegative men (6.5 vs. 2.6; p=.0004, asymptomatic-5.8 and symptomatic=9.7). Hopelessness indicated an increased risk of suicide which is independent of depression. Past psychiatric history (r=0.38), hopelessness (r=0.55), and poor social adjustment (r=0.55) accounted for 49.8% of the variance (p.001). HIV seropositive men exhibited more psychosexual dysfunction especially premature and delayed ejaculation (30% vs. 4% and 20% vs. 0, respectively; p.05) than HIV seronegative men. Among the men who had a sexual relationship, HIV seropositive men tended to always use condoms during intercourse (79% of asymptomatics and 100% of symptomatics vs. 25% of HIV seronegatives; p=.0004). Even though they used condoms, HIV seropositive men were more likely to worry about infecting their partners than HIV seronegative men (p=.02).
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PMID:The psychosocial impact of HIV infection in men with haemophilia: controlled investigation and factors associated with psychiatric morbidity. 161 81

A comparative evaluation of eight psychometric instruments was made in 274 patients who were currently suffering or previously had suffered from low-back pain. The specificity and sensitivity values for detection of psychological disturbance were calculated and optimum cutoff scores determined for each test. The influence of current pain, social group, compensation, migrant status, and unemployment on the accuracy of each test were evaluated. The Pain Drawing, the Inappropriate Symptoms, the Inappropriate Signs, and the Illness Behavior Questionnaire were found to be least discriminating. The Modified Somatic Perception Questionnaire, the Hospital Anxiety Scale, the Hospital Depression Scale, and the Zung Depression Scale were the most accurate and least affected by the factors examined. The combination of the Modified Somatic Perception Questionnaire and the Zung Depression Scale yielded specificities and sensitivities of 91% and 84% for men and 96% and 85% for women, respectively. This combination is recommended for the assessment of psychological disturbance in patients with low-back pain.
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PMID:Comparison of eight psychometric instruments in unselected patients with back pain. 183 63

138 (60%) of 230 African patients with epilepsy consecutively referred to the neurology clinic, Muhimbili Medical Centre, Dar es Salaam, had a psychological disturbance warranting intervention. 81% of them had only minor disturbance, dominated by neurotic disorders. 19% had a major disturbance dominated by a schizophrenic form of psychosis. Other major disturbances were hysterical reactions, agarophobia and severe depression. Organic brain disease was significantly associated with psychological disturbance. Over 80% of patients with major disturbance had epilepsy and brain-lesion and 77% of patients with minor disturbance had evidence of an organic brain lesion. Organic brain lesion and psychological disturbance was overwhelmingly associated with social disadvantage. Although the social attitude to epilepsy is still negative in Africa, psychological disturbance and social disadvantage in the African Tanzanian epileptic seem to be more strongly related to an organic brain lesion than to be a result of the individual reaction to social prejudices.
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PMID:Psychological disturbance in African Tanzanian epileptics. 210 79

The process of international migration has been associated with increased levels of psychological disturbance and recently investigators have noted the experience of PTSD symptoms among recent war refugees from Southeast Asia. This study sought to first examine the overall impact of migration in a large sample of immigrants from Central America and Mexico in terms of symptoms related to depression, anxiety, somatization and generalized distress. A second aim of the study was to note the existence of specific symptoms related to PTSD diagnoses as related to self-reported reasons for migration. Immigrants were found to have overall higher levels of generalized distress symptoms when compared to non-immigrants, and self-reported reasons for migration were highly related to PTSD diagnosis, with 52% of Central American war refugees in this sample meeting the DSM-III criteria for the disorder. Results are discussed in terms of sensitizing mental health professionals to the psychological sequelae of forced migration.
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PMID:[Migration and post-traumatic stress disorders: the case of Mexicans and Central Americans in the United States]. 210 50

Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who had poorly controlled epilepsy but no significant psychological disturbance received one type of psychological treatment after a stable baseline. The treatments were educational and were designed to improve coping skills. Weekly seizure frequency was monitored for 42 weeks, and self-rating measures of anxiety and depression were obtained before treatment and at the end of follow-up. All three groups showed a significant reduction in seizure frequency that was maintained at 6-month follow-up. The two groups with psychological symptoms showed a significant improvement in scores on the self-rating scales. We concluded that routine use of psychological intervention may be helpful in outpatient management of epilepsy.
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PMID:Refractory epilepsy: an evaluation of psychological methods in outpatient management. 219 70

A principal factor analysis, conducted on a mixed psychiatric outpatient sample (N = 470), identified both common and specific dimensions underlying anxiety and depression. Although an initial single-factor extraction accounted for a significant proportion of variance in cognitive and symptom measures of anxiety and depression, a two-factor solution, in which anxiety and depression formed separate dimensions, proved to be the better solution. MANOVAS performed on pure depressed, pure anxious, and mixed anxious/depressed subgroups provided evidence of a specific cognitive profile for anxiety and depression. The mixed subsample evidenced greater severity, a mixed cognitive and symptom profile, and character traits that may indicate increased vulnerability to psychological disturbance. Results are discussed in terms of Beck's (1976) cognitive content-specificity hypothesis and the positive-negative affect model (Watson & Tellegen, 1985).
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PMID:Cognitive specificity and positive-negative affectivity: complementary or contradictory views on anxiety and depression? 234 8

The prevalence of psychiatric disorder in 48 patients with chronic fatigue syndrome (CFS) was determined. Twenty-two had had a major depressive (non-endogenous) episode during the course of their illness, while seven had a current major (non-endogenous) depression. The pre-morbid prevalence of major depression (12.5%) and of total psychiatric disorder (24.5%) was no higher than general community estimates. The pattern of psychiatric symptoms in the CFS patients was significantly different to that of 48 patients with non-endogenous depression, but was comparable with that observed in other medical disorders. Patients with CFS were not excessively hypochondriacal. We conclude that psychological disturbance is likely to be a consequence of, rather than an antecedent risk factor to the syndrome.
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PMID:The psychiatric status of patients with the chronic fatigue syndrome. 224 82


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