Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-nine out of 60 persons who committed suicide had been under the care of 71 physicians within 6 months or less before committing suicide. Over two thirds of the patients had histories of suicide attempts or threats. These histories were known to only two fifths of the physicians responsible for their care, despite the information being readily available from other sources. There was substantial evidence of depressive illness in three quarters of the patients, yet the diagnosis was rarely made except by psychiatrists, and therefore the depression was rarely treated. Although a few patients had been recognized as representing suicidal risk, the great majority had not. The failure to diagnose and to treat depressive illness and the failure to be informed about the risk factors in these cases represent missed opportunities for preventive intervention.
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PMID:The physician's responsibility for suicide. II. Errors of omission. 111 63

The characteristics of 64 suicides with a retrospective diagnosis of depression and 128 depressives referred for psychiatric treatment were compared. The following items differentiated the suicide group: male sex, older age in females, single status, living alone, the symptoms of insomnia, impaired memory and self neglect, and a history of suicide attempts. The value of these items in assessing suicide risk in depressive illness is discussed.
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PMID:Depression followed by suicide: a comparison of depressed suicides with living depressives. 111 31

23 cases are demonstrated, in which the connection between drug use and sudden death is to be accepted. The victims are only males and juveniles. It is demonstrated by the cases reported, that upon the sudden death of a juvenile increased consideration must also be given to a possible connection between death and drug use. First and foremost the drug used is susceptible of leading to death by way of an intoxication due to too large a dosage or owing to oversensitiveness. Far advanced putrefaction, the combined effects of several drugs including alcohol, the difficulty in furnishing chemical proof of the presence of hashish and LSD in body-fluids and organs can make it nearly impossible to clarify the cause of death. Only what has been related in respect of the manner of living and drug use by members of the family, mates and friends makes the connection between death and drug use appear quite likely. The indirect connection between drug use and the juvenile's death is to be accepted if it comes to the accident under the influence of drugs - be it under the impression of invulnerability or omnipotence or in a state of hallucinations. Depressions under the influence of drugs are also susceptible of resulting in real suicidal actions. In case of inexplicable accidents or entirely unexpected suicide drug effects must, therefore, nowadays be thought of.
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PMID:[Drug use leading to death (author's transl)]. 112 Dec 98

Depression is a common reaction to the vicissitudes of life among elderly people. Aged persons are physiologically and psychologically less able to adapt, yet they are required to change their life styles because of retirement, lowered financial resources, death of family and friends, and illness. Although many mental health professionals are reluctant to treat geropsychiatric patients, the prognosis for depressed patients can be good. Drug therapy is usually the most effective, although psychotherapy and other behavioral therapies may be used adjunctively. Electroconvulsive therapy (ECT) may be indicated for severely depressed patients. The beginning dosage of medication should be lower than for younger patients, and elderly patients must be monitored carefully for side effects. Adverse reactions due to multiple drug interactions are also possible. When aged persons become severely depressed, they are at high risk of suicide; almost all suicide attempts by elderly people are successfl. Depression in later life is treatable, and the pessimism that often surrounds the prognosis for geropsychiatric patients is unwarranted.
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PMID:Depression in elderly patients. 112 12

The wacinko syndrome in the Oglala Sioux varies from a nonclinical reaction to pathological degrees of anger, pouting, withdrawal, depression, psychomotor retardation, mutism, immobility, and even to suicide. Although indigenous proctitioners recognize the syndrome as a distinctive disorder, it has not been described by non-Indian practitioners. The author presents a case report and suggests that most cases are diagnosable as reactive depressive illness.
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PMID:A syndrome of depression and mutism in the Oglala Sioux. 113 26

The current literature on suicide by medicinal overdose among the elderly population of the United States and Britain is discussed. The older white male is a high risk in this regard. Physical and mental illnesses contribute to the problem of suicide among the aged, and some of the drugs prescribed for treatment (e.g., barbiturates and psychotherapeutic agents) are often accessible to the older person for misuse in suicide. The responsibilities of the prescribing physician and the practices of the dispensing pharmacist are considered in relation to the exposure of the elderly patient to potentially lethal drugs. Prediction of suicidal attitudes in the elderly is complicated by the fact that any attempt at suicide usually is serious and rarely preceded by gestures. Depression, based on social factors, is common among older people. Some of them face problems of declining income and prestige, as well as a loss of physical and mental powers. A change in the attitude of society towards the elderly may help to alleviate the depressive state which so often contributes to the suicidal potential.
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PMID:Suicide by overdoses of medicines among the aged. 114 30

The authors administered measures of depression, hopelessness, and strength of suicidal intent to a sample of 112 suicide attempters. The results for the 55 subjects diagnosed as depressive and admitted within 72 hours after their attempt were compared with results obtained by Minkoff and associates using comparable measures. Contrary to the findings of the earlier study, there was a lower correlation between hopelessness and intent than between depression and intent. The authors suggest that demographic differences between the two samples may provide explanations for this descrepancy, in the that they reflect the presence or absence of external societal supports that may influence the suicidogenic potential of hopelessness.
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PMID:Hopelessness and attempted suicide: a reconsideration. 115 33

Patients were treated with protriptyline or nortriptyline (double-blind). They were assessed on the Zung Depression Scale and on the Hostility and Direction of Hostility Questionnaire (HDHQ). A good response was heralded by low ratings on criticism of self and others,and on projected (paranoid) hostility. The outcome was better with initial low scores on depressive symptoms, particularly unworthiness, restlessness and constipation. As to reported side effects, initial loss of interest augured badly for drowsiness, lack of clear mind for blurred vision, loss of libido for constipation and ideas of suicide for dry mouth.
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PMID:Hostility, somatic symptoms and recovery with antidepressants. 115 28

An attempt was made to identify background, sociodemographic and clinical variables which are associated with attempted suicide in depression. Within a sample of 308 depressed psychiatric inpatients, suicide attempters were younger than non-attempters and were identified by a pattern of chronic interpersonal maladjustment reflected clinically in withdrawal from social contact and the display of hostility or irritability toward others.
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PMID:Factors associated with attempted suicide among hospitalized depressed patients. 119 40

Qualitative or quantitative deficiency of maternal "primary love" in the critical period of the first years of life very often leads in later years of life to severe psychosomatic disorders or psychopathologic states as depression, suicide, addiction, criminality, social disorders and psychosis. A Preventive Care Passport with a date program for the pregnant woman and young mother and a standardized program for the gynaecologist is proposed in connection with all necessary perinatal preventive methods and integration of psychohygienic investigation and treatment. Perinatal psychohygienics could be practiced by questionnaires to find out maternal pathogenic conflicts, by social workers in order to avoid unnecessary maternal work in the first years of her child's life and group discussions after a 16-mm-film or an information paper about the normal psychic development of a child. Further tasks are granting the presence of the father at childbirth "rooming-in" with "self-demand", early adoption within the first eight weeks of life, group discussions of parents about conflicts with their children, hospitalization of infants -- only in cases of vital indication -- together with their mother and psychological preparing for medical manipulations and social benefits for the young mother or parents. The recommendations of the WHO for the application of psychohygienics could be integrated in this program.
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PMID:[Perinatal psychohygienics -- importance and chance of a primary preventive medicine by the gynaecologist (author's transl)]. 121 Apr 83


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