Gene/Protein
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Pivot Concepts:
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Drug
Enzyme
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Target Concepts:
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Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Depressive symptoms assessed by the Beck
Depression
Inventory were compared in 97 cancer patients, 66 next-of-kin of cancer patients, and 99 physically healthy persons who attempted
suicide
. Less than a fourth of the cancer patients and a fifth of their next-of-kin but over half of the psychiatric patients were moderately or severely depressed. The two patient groups were indistinguishable in somatic depressive symptoms, both scoring higher then the next-of-kin. The cancer patients and the next-of-kin were indistinguishable in nonsomatic (psychological) depressive symptoms, both scoring lower than the
suicide
attempters. Younger patients reported more nonsomatic symptoms than older ones. Beck scores and nearness to death were not associated in 57 cancer patients who expired. Vegetative depressive symptoms in cancer patients may reflect advanced disease, but nonsomatic symptoms should be reason for psychiatric consultation.
...
PMID:Comparative studies of psychological function in patients with advanced cancer--I. Self-reported depressive symptoms. 89 49
With the aid of an instrument constructed by the author especially for the purpose, this study examined the suicidal behavior of a representative sample of the normal population (3086 subjects). The results make it possible to describe a suicidal-depressive personality along the dimensions of its basic elements, its accompanying phenomena and consequences, and finally the genetic aspects of
depression
. The main elements of both the suicide attempt and the suicidal tendency are identical, although they are more intense and clearcut in the suicide attempt. Another noteworthy result of this study is the frequency data: the
suicide
tendency was found in 15 to 35% of the cases, according to the various sub-groups; and the suicide attempt in 2.5-13%. These percentages lie far above the currently known estimations.
...
PMID:[The field of suicide. Empirico-statistical study on 3086 examined persons of both sexes and from 2 cultural spheres]. 90 93
The typology of and theories on suicidal behavior are reviewed to integrate various points of view in terms of the paranoid process. Freud's theory of internalized aggression, the relation of
suicide
impulses to
depression
, the operation of narcissistic components in the complex motivation of
suicide
are related to the concept of the victim-introject as central to the pathology of
suicide
. Suicidal patterns play out the dynamics inherent in the victim-introject and its correlative component the aggressor-introject. The victim-introject serves as the core internalization around which a false-self system is organized; the
suicide
represents the attempt to destroy the false-self as a means of realizing the dynamic purposes of the victim-introject. The concept of the victim-introject integrates previous psychoanalytic formulations of
suicide
and provides a template for the development of a therapeutic rationale. Implications for therapeutic response are considered, particularly in terms of the need to undermine the patient's attempts to maintain and reinforce his victimization.
...
PMID:Psychoanalytic notes on suicide. 91 50
One hundred fifty-four
suicide
attempters, threateners, and psychiatric controls were rated on
suicide
intent scales and given tests to assess hopelessness,
depression
and self-rated
suicide
risk. Ninety-four subjects were retested one month later. Both hopelessness and
depression
were significantly greater in suicidal subjects. In threatenets, hopelessness and
depression
scores differed significantly between high and low
suicide
intent subjects. In attempters ranked by
suicide
intent at time of testing, more and less suicidal subjects differed significantly in hopelessness and
depression
scores. Both
depression
and hopelessness were sensitive to changes in
suicide
risk during the one-month follow-up. In all analyses, hopelessness correlated more highly with
suicide
intent than did
depression
. The data were regarded as supporting the hypothesis that hopelessness is more closely related to
suicide
intent than is
depression
.
...
PMID:Hopelessness, depression, and suicide intent. 96 91
In a study of 106 predominantly young, lower-social-class men participating in a methadone maintenance program, the authors found that about one-third were moderately to severely depressed as assessed on standard rating scales of
depression
. The depressive symptoms were associated with a decrease in social functioning, increase in stress in the past 6 months, and a history of alcohol abuse. Because the combination of
depression
and drug addiction creates a high risk for
suicide
, depressive symptoms require early detection and treatment. The authors point to the need for more research on treatment approaches, particularly the use of psychotropic drugs.
...
PMID:Clinical depression among narcotic addicts maintained on methadone in the community. 98 44
The youthful habits and family attitudes of medical students who later developed or died from one of five disease states were different from those of healthy classmate controls to begin with. In medical school, the total disorder group had significantly more nervous tension, anxiety, and anger under stress, had more insomnia, smoked more cigarettes, and took alcoholic drinks more frequently. Individual disorder group means were significantly different from each other. The mental illness group showed the most nervous tension,
depression
, and anger under stress and the malignant tumor group the least. The malignant tumor group resembled the healthy control group in these respects. The
suicide
, mental illness, and malignant tumor groups had low mean scores for closeness to parents, while the hypertension and coronary occlusion group means were slightly higher than the control group mean. Thus psychologic differences in youth have predictive potential in regard to premature disease and death.
...
PMID:Precursors of premature disease and death. The predictive potential of habits and family attitudes. 98 20
This study examined the hypothesis that there are seasonal variations for
suicide
, hospital admissions for depressive illnesses and electroconvulsive therapy and that these are inter-related. It was found that the seasonal variations did coincide, with peaks occurring in the Ontario spring and autumn. The importance of
depression
as a cause of
suicide
and the effect of electroconvulsive therapy upon the
suicide
rate are discussed.
...
PMID:Seasonal patterns of suicide, depression and electroconvulsive therapy. 99 Jun 62
A study has been made of cases coming before the Brighton coroner in the period 1970-2. Fifty cases in which a
suicide
verdict was recorded were specially studied, and relatives and acquaintances of the deceased were interviewed. The information thus obtained was compared with information available to the coroner in considering his verdict in 83 further cases in which he made a verdict of '
suicide
'. The reliability of the contemporary information on which the coroner's decision is based was largely validated. A study was made of variables which differentiated '
suicide
' from 25 'open' and 33 'accident' cases considered by the same coroner. The prevalence of
depression
did not differentiate '
suicide
' and 'open' cases, and this finding contradicts suggestions that the association of
depression and suicide
might be an artefact of the method of arriving at a
suicide
verdict. A number of other demographic and clinical factors did however significantly vary between '
suicide
', 'open' and 'accident' cases.
...
PMID:Clinical and social variables which differentiate suicide, open and accident verdicts. 99 2
Interviews with seven of ten known survivors of jumps from the Golden Gate Bridge and San Francisco-Oakland Bay Bridge revealed that all of them experienced transcendence and spiritual rebirth phenomena. The psychotherapeutic implications of these findings lie in helping depressed and suicidal individuals confront death in a symbolic and meaningful way. The issue is one of "egocide" (symbolic
suicide
) and aiding individuals in the rebirth process. In this way actual suicides can be prevented. When individuals experience partial "deaths" (like loss, failure, rejection,
depression
, suicidal states, or negative parts of their egos), there is opportunity for "rebirth" (positive transformation, creative change, growth, and significant spiritual reawakening). The therapeutic task is to help individuals differentiate between "ego death" and total death and to discover through the creative process of psychotherapy that overt
suicide
need not be a solution.
...
PMID:Suicide survivors: psychotherapeutic implications of egocide. 102 53
Suicide is seldom, if ever, a comfortable subject to deal with. Medical school curricula, for various reasons, are too often unable to include the subject in a useful way, and consequently physicians feel unprepared when confronted with a severely depressed or desperate patient in practice. In addition,
suicide
is an unsettling reality because it relects and reminds us of our own frailty and humanity. Nearly everyone has had an experience of
depression
or some fleeting thought of
suicide
at some time in his life. Growing up can often be almost unbearably painful at certain times during adolescence. Middle age inevitably brings with it losses, possibly of loved ones, and with this uncertainties about whether it is really all worth the effort. And as age advances, health and vigor and aspirations slowly depart. Exactly when, at times of crisis such as these, suicidal thoughts take over and lead to action is difficult to define, but the physician must always be prepared for this possibility. Factors have been described which may be useful in alerting the physician to the possibility of
suicide
. Physical illness may give rise to feelings of hopelessness to which the physician must stay attuned; the patient may also use physical illness as a pretext for seeking help for deeper things that trouble him. As Havens points out, neither reassurance, nor criticism, nor abbreviating the interview will help the situation of a desperate patient. Clarification of the patient's feelings and thoughts are mandatory. Psychiatric consultation can be an important adjunct in achieving this goal and may at times be life saving.
...
PMID:Evaluating suicidal risk. 104 88
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